Top Tweets for #indapamide
#FDA approved #GeorgeMedicines’ #Widaplik (#telmisartan + #amlodipine + #indapamide), the 1st triple combo tx that can be used earlier line to help lower BP #Polypharmacy #Hypertension #MedTwitter https://t.co/90LJcGw6Nl
💢#Kidney_Stones: #Preventive Drug Therapy
✅High urine #Calcium:
➤We prefer long-acting #Thiazides (#Chlorthalidone, #Indapamide) over short-acting Thiazides (#HCT).
✅Low urine #Citrate:
➤#Potassium_Citrate
➤#Potassium_Bicarbonate
✅High urine #Uric_acid:
➤#Allopurinol

Four 💊, quarter-dose BP-lowering combination of #candesartan 2 mg + #amlodipine 1.25 mg + #indapamide 0.625 mg + #bisoprolol 2.5 mg ➡️ a -4.8/-4.9 mmHg greater ⤵️ in change in BP from baseline to 12 wks compared with standard-dose #ARB mono Rx in mild to moderate #HTN
#AHA22
1 higher dose ARB vs 4 mini doses of quadruple anti-hypertensive drugs for BP control? QUARTET USA studied the hypothesis, watch Dr @YazDaaboul and Dr. Mark Huffman discuss results here #AHA22
@ACCinTouch @JACCJournals
URL here: https://t.co/cjqYbgTk4g
Day 5 #indapamide ADEs: Common incl hypersensitivity reactions, rash & clinically significant electrolyte disturbances e.g hypokalaemia; needs pre-therapy & regular monitoring. Rare/serious incl angioedema,renal failure, SCARs, aplastic anaemia, vision disorders (NOT exhaustive)
Day 4 MOA: #indapamide ↓ BP mainly via vascular action (not diuresis) by Ca+ uptake impairment > ↓ smooth muscle cell reactivity. Also vasodilation via ↑ PGE2, prostacyclin & bradykinin levels (also relevant to ↓ platelet aggregation). Reduces left ventricular hypertrophy.
Day 3: Kinetics #indapamide;good oral absorption, cmax 1-2 hrs.
Binds to RBCs & plasma proteins, then taken up thru vascular walls where it acts. Liver metabolism via CYP3A4 with 1 active metabolite. Renal excretion (avoid in severe impairment), but ~ 23% GI excr. T½ 15-18 hrs
Day 1: Labelled a ‘thiazide-like’ diuretic (as acts in the distal convul tubule), #indapamide is a non-thiazide sulfonamide. Derived in late 60s from benzamide (found in plants e.g autumn crocus), it was designed to retain blood pressure lowering effect as separate from diuresis
#mdpipharmaceutics Physical Ageing of Amorphous #Indapamide Characterised by Differential Scanning Calorimetry https://t.co/whTlcsvvwp This article belongs to the Special Issue Drug Polymorphism and Dosage Form Design https://t.co/mqLvHOGcyr

Hectic weekend in #Mumbai.
Talk no. 2.- revisiting the landmark ADVANCE trial after more than a decade. Treating #BP effectively in #diabetes with #ARB+#diuretics reduces #cardiac events and #mortality
#hypertension #perindopril #indapamide

Just rx’d #canagliflozin to a diabetic w eGFR 37ml/min and #indapamide to a frail older diabetic w uncontrolled HTN on HCTZ. Am I doing this right @ChristosArgyrop ?
@NephJC It was a while ago, but it slowed the rise, as one might expect. Patient was fine. As usual, #indapamide was the culprit. #NephJC
Please find the revised version of our previous post #indapamide


#Drug Talk
#Indapamide - The best #Diuretic, says Dr. Anirudh Chandorkar
@RubyHallClinic #TheRightDoctors

In two meta-analyses, #hypertension outcomes better for #chlorthalidone or #indapamide versus #hydrochlorothiazide http://t.co/ORVqID177M
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