Top Tweets for #iwAL26
Fantastic conference chaired by @Daver_Leukemia and great session on menin inhibitors in which we are all excited about combination strategies and moving into frontline Tx. Thanks for inviting me to be part of this program #iwAL26
🧬 Session 10 at #iwAL26: Menin inhibitors in AML, chaired by Naval Daver (@Daver_Leukemia) & Andrew Wei!
From 2nd-gen inhibitors, MEN1 mutations & resistance (Justin Watts), to menin inhibition for MRD (Ghayas Issa/@GhayasIssa), breaking resistance with combos (Emma Searle/@DrEmmaSearle), and menin inhibitor triplets beyond unfit/older AML (Joshua Zeidner/@LeukDocJZ) there was plenty of lively discussion!
#iwAL #AML #Menin #LeuSM
🧬 Session 11 at #iwAL26: TP53-mutated #AML, chaired by David Sallman & Eunice Wang (@EuniceWangMD)!
New approaches to targeting TP53m AML (Andrew Wei), TP53m AML & transplant (Pramila Krishnamurthy/@drpramila), current challenges & future strategies (Maximilian Stahl/@MaxStahlMD), plus a TP53 "potpourri" (Gabriel Mannis)
#iwAL #LeuSM
@VJHemOnc @Daver_Leukemia @GhayasIssa Great session. The resistance talks are the crux though. If MEN1 mutations reliably predict relapse, shouldn't we be sequencing menin therapy by MRD from the start rather than after failure? #iwAL26
🧬 Session 10 at #iwAL26: Menin inhibitors in AML, chaired by Naval Daver (@Daver_Leukemia) & Andrew Wei!
From 2nd-gen inhibitors, MEN1 mutations & resistance (Justin Watts), to menin inhibition for MRD (Ghayas Issa/@GhayasIssa), breaking resistance with combos (Emma Searle/@DrEmmaSearle), and menin inhibitor triplets beyond unfit/older AML (Joshua Zeidner/@LeukDocJZ) there was plenty of lively discussion!
#iwAL #AML #Menin #LeuSM
What a privilege to share the podium @VJHemOnc #iwAL26 with my brilliant co-panelists @doctorpemm @MrinalPatnaik . Their contributions have moved the needle on rare diseases like #BPDCN & #CMML & greatly improved the life of our patients.
We rounded out Day 2 of #iwAL26 with an exciting session on clonal hematopoiesis, #BPDCN and #CMML chaired by Naveen Pemmaraju (@doctorpemm) & Uma Borate (@beatalleukemia)!
Covering early intervention trials in CHIP/CCUS (Uma Borate), new approaches to BPDCN (Naveen Pemmaraju), and blast-transformed CMML biology/outcomes (Mrinal Patnaik/@MrinalPatnaik).
Great panel discussion to wrap up the day! 🫶
#iwAL #AML #LeuSM
🧬 Session 8 at #iwAL26: Transplantation in AML, chaired by Charles Craddock (@charliecraddock) & Victoria Potter!
Charles Craddock on reducing relapse risk post-transplant, Samer Srour on precision-engineered T-cell therapy for alloHSCT, then a debate on pre-transplant intervention in MRD+ AML CR1
🥊 @TapKadia (yes) vs. Victoria Potter (no) 🥊
#iwAL #AML #LeuSM
Session 7 at #iwAL26: Value & utility of MRD in newly-diagnosed AML, chaired by Eunice Wang (@EuniceWangMD) & Gail Roboz!
Christopher Hourigan (@DrChrisHourigan) on whole genome-informed diagnosis & MRD testing, then a lively debate on whether NGS-based MRD is the key outcome surrogate - @CLachowiez (for) vs. Richard Stone (against) 🥊
#iwAL #LeuSM #AML #MRD
Session 6 at #iwAL26: Targeting FLT3-mutant #AML, chaired by Naval Daver (@Daver_Leukemia) & Catherine Smith (@SmithLabSF)!
Covering frontline approaches for fit patients (Naval Daver), whether your FLT3 inhibitor choice matters (Alexander Perl), managing FLT3-ITD+ AML in remission (Eunice Wang), and resistance mechanisms (Catherine Smith)
#LeuSM #Leukemia #iwAL
Rowley's cytogenetics laid the foundation for every molecular classification we use in AML today. Imagine what she'd have done with modern sequencing. I love that Nimer is telling this story properly. #iWAL26
Dr. @DrSDNimer taking us through some fascinating AML history at #iWAL26
Dr. Janet Rowley, who first identified the Philadelphia Chr. & later t(8;21) would’ve been 99 today🤍
In her time, Med schools had a 3 women/year quota. We’ve come a long way, diagnostically & culturally, thanks to these pioneers.
🧬 Session 5 at #iwAL26: Immunotherapies in #AML, chaired by Pinkal Desai (@DrPinkalDesai) & Roland Walter (@RolandBWalter)!
Featuring AVC-201's switchable CAR-T (Marion Subklewe), SENTI-202's logic-gated cell therapy (Stephen Strickland/@SAStricklandMD), novel T-cell engager targets in R/R AML (David Sallman), and pivekimab sunirine (Naval Daver/@Daver_Leukemia).
#iwAL #LeuSM
Dr. @DrSDNimer taking us through some fascinating AML history at #iWAL26
Dr. Janet Rowley, who first identified the Philadelphia Chr. & later t(8;21) would’ve been 99 today🤍
In her time, Med schools had a 3 women/year quota. We’ve come a long way, diagnostically & culturally, thanks to these pioneers.
🔥 Session 4 at #iwAL26 diving into venetoclax in AML - chaired by Andrew Wei & Uma Borate (@beatalleukemia)!
From optimal dosing (OPTI-AML, Uma Borate) to combining VEN with intensive induction (Courtney DiNardo) and getting duration/de-escalation just right (Stéphane de Botton).
Great panel discussion to close it out!
Session 3 at #iwAL26: New frontiers in #MRD for #AML - regulatory perspective & clinical practice, chaired by Naval Daver & Eunice Wang (@EuniceWangMD).
Talks on cell-free DNA determinants of AML MRD (Tian Yi Zhang), MRD as a clinical trial endpoint (Gege Gui), and FDA's regulatory perspective on AML MRD (Cara Rabik).
#AML #LeuSM #LeuSM
Great talks today at #iwAL26 in Cambridge, MA from Drs @GegeGui0 and Sushree Sahoo. https://t.co/blhBvtfKO3 @vt_dcarea @FralinBiomed
Session 2 at #iwAL26: New science implications for #AML, chaired by John DiPersio & Coleman Lindsley.
Talks on stem cells in human AML (Asiri Ediriwickrema/@Asiri_E), PI3Kγ inhibition in AML (Andrew Lane/@lane_andy), and STAT3 inhibition in MDS/AML (Aditi Shastri/@aditishasMD).
#LeuSM #Leukemia #iwAL
Another wonderful session at #iwAL26: Translational & lab developments in AML, chaired by Stephen Nimer (@DrSDNimer) & Catherine Smith (@SmithLabSF).
Talks on RAS biology in frontline AML/CMML (Sandra Misale/@Sandra_Misale), telomeres in AML (Coleman Lindsley), novel AML immunotherapy targets (John DiPersio) & endogenous models of chromosomal alterations (Sushree Sahoo)
#iwAL #Leukemia #AML #LeuSM
Great session on Differentiation Syndrome at #iwAL26!
Chairs Eytan Stein & Courtney DiNardo led deep dives into DS biology/pathogenesis and clinical presentation/management with menin inhibitors incl. ziftomenib
#DifferentiationSyndrome #iwAL #Leusm
@@GhayasIssa @EuniceWangMD @LeukDocJZ
At #iwAL26 Coleman Lindsley (@DanaFarber) discusses telomere dynamics in normal and pathologic aging
#Leukemia #LeuSM #
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