Top Tweets for #mthfd2
🚀#RA におけるNFATc1–MTHFD2軸
T細胞は#関節リウマチ（RA）における慢性炎症を駆動しますが、既存治療では病原性T細胞の活性を十分に抑制できない場合があります。
#NFATc1 は直接 #MTHFD2 を活性化し、ワンカーボン代謝を再プログラムすることで、RAにおける炎症性T細胞応答を維持します。
💊MTHFD1/2阻害（#TH9619）：
↓ 炎症性サイトカインの産生
↑ Foxp3⁺ 制御性T細胞
↓ in vivoでの関節破壊
🔬本研究は、NFATc1–MTHFD2転写‐代謝軸が持続的なT細胞炎症の主要因であり、RA治療における有望な代謝標的であることを示しています。
MedChemExpressは本研究で使用された#Tacrolimusおよび#CyclosporinAを提供し、T細胞媒介性炎症経路の研究をサポートしています。
📎https://t.co/2NjErAvTd7
📎https://t.co/Pxwkyx0lxJ
👉Don't miss this - now online!
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
🔓https://t.co/OgeLPCwkxz
#MTHFD2 #DNArepair #IonizingRadiation #DNAdamage @mortusewicz @Thomas_Helleday
If you want to know everything about #MTHFD2's canonical and non-canonical functions, check out @NataliaPardoL's just-published review.
@Nature_NPJ
@ERC_Research @Boehringer Ingelheim Fonds PhD fellowship @CRGenomica
👇👇👇👇
https://t.co/F8FaQdMSUL
We are thrilled to present the new study from our lab. We uncover #MTHFD2 as a collateral lethal gene target in #ovariancancer. We found a MTHFD2 driven noncanonical #NAD flux in #ETC suppressed cancers.
@NatMetabolism @UMRogelCancer @UMBME @NCICancerBio
https://t.co/PVoCfE32vM
Dr Ana Slipicevic, CEO of https://t.co/iDlvIjsYBU wins pitch prize at @MATWIN_Bdx presenting the #MTHFD2 target
Piece of the puzzle FOUND. #MTHFD2 is a metabolic checkpoint controlling #Tef and #Treg cell fate and function @VUMC @JeffreyRathmell @sonomabio @enhancerleo @AtUcsf @kickassscience1
https://t.co/cYG6Tqr3NY
Team effort from @SugiuraAyaka (G6), @madden_mz (G5), & Nowrin Chowdhury (G3) now out in @ImmunityCP! This study shows one-carbon metabolism enzyme #MTHFD2 is a regulator of #Tcell fate and could be a potential therapeutic target: https://t.co/gU9PTTAtrK
👍👍#MTHFD2 is a metabolic checkpoint controlling #Teff and #Treg fate and function ➡️ and #MTHFD2 possible TARGET vs #inflammation #autoimmunity in vivo
@vumcdiabetes @uiowa @Princeton @ufdiabetes @UMassDiabetes @AtUcsf @ekaterine1973 @SoleimanpourLab
https://t.co/9PpNRa0Cax
Great presenting and discussing this #preprint @preprintclub yesterday. Interesting work by @SugiuraAyaka @JeffRathmell and Joshua Rabinowitz. Really looking forward to further studies on #MTHFD2. Wrote a small digest on our website: https://t.co/pIRoechgXJ
Follow @preprintclub
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