Top Tweets for #pathpitfall
#Pathpitfall alert
HER2 IHC: Cytoplasmic staining? Now what?
✅ Focus only on membrane staining (cytoplasmic is nonspecific & ignored for scoring).
✅ More common with some assays than others (4B5 > HercepTest)
✅ If diffuse cytoplasmic staining obscures membrane evaluation:
→ Run FISH
→ Repeat IHC on a different block to identify membrane staining
→ Or switch to another validated HER2 assay if available.
Dr. Huina Zhang #USCAP2026 #pathology @Pathology_URMC #PathX #pathtwitter
#GIPath #PathPitfalls
Thank you @RaulSGonzalezMD for sharing this possible #PathPitfall to be aware of. ↘️
High-grade colonic tubular adenoma with focus of invasive adenocarcinoma? Not quite. This TA is just involving a submucosal lymphoglandular complex. This rare finding should not be mistaken for malignancy. Great recent case series here: https://t.co/1RYqBTF6Uu #pathology #gipath
Here is an intraductal papilloma involved by collagenous spherulosis (! not ADH/DCIS)
#PathBoards #PathPitfall
What a great day!
I managed to trick a resident into calling thymus metastatic PTC (you know this is one of my favorite pitfalls!)
AND I got to pet Kobe, the therapy dog! ❤️❤️❤️
#PathPitfall
Listening to the great (and surprisingly entertaining) @RaulSGonzalezMD teaching our @USFpathology residents today, he discussed GCT in the GI tract which prompted me to think of this classic #PathPitfall in the head and neck!
#PathPitfall, The Look Deeper Edition:
At low power, pseudoepitheliomatous hyperplasia overlying granular cell tumor may be more eye-catching than the GCT itself -can be so proliferative that it looks like SCC. Look deeper! S-100 IHC impressively highlights tumor cells.
#ENTPath
#PathPitfall Breast Biopsy-Displaced Epithelium
🔬Biopsy procedure➡️may lead to lesion disruption
🔬More common in papillary lesion
⚠️Misdiagnosis of invasive carcinoma or LVI
❗️Myoepithelial markers,if +, is helpful, but can be -
❗️Favor displacement if fragment in biopsy tract
🎃👻
Next up for our #Halloween “Cells in Costume” series:
Medullary thyroid carcinoma pretending to be a paraganglioma with “zellballen” architecture!
#EndoPath #PathPitfall
👻Happy #Halloween! 🎃
A time to dress up and pretend to be something different, just like these #Pathology entities!
Here’s some parathyroid pretending to be thyroid! (Pseudofollicular change)
What’s your favorite pathological mimic? #PathPitfall
Today’s #FNAFriday #CytoHisto correlation
🧶Lots of spindled cells mixed with glandlike epithelioid elements in biphasic synovial sarcoma
(DQ & H&E)
🧬SS18-SSX fusion
👉🏼#PathPitfall: Epithelioid components mimic adenocarcinoma
Today’s #FNAFriday #CytoHisto correlation
🐓Chicken-wire vasculature, myxoid matrix, signet ring lipoblasts in myxoid liposarcoma
(DQ & H&E)
🧬t(12;16)(q13;p11.2) FUS-DDIT3 in most
👉🏼#PathPitfall: bubbly background and signet rings can raise c/f adenocarcinoma!
Love a #PathPitfall?! Come out Monday evening for some tricky Head and Neck cases with #ENTPath superstars @HandNPath @PathDocBoston @WeinrebIlan and…me!
#USCAP2023 @TheUSCAP
Pitfall Alert!!!
Seen at the site of bowel perforation..
What do you think #pathtwitter #GIpath ?
Signet ring cells?? Pseudo signet ring cells??
Answer in the next tweet...
@Mvgs1706 @BIDMCpath @ALBoothMD @Vik_deshpandeMD @Teclis82 @DrMarkOng @navale_pooja @UJoneja @natzpat @YuhoMD Wow, Monika, this is a real #Pathpitfall,muciphages usually in lamina propria and these ones also look so signet ring like and even the nuclei don't look so innocent .
Thank GOD for the existence of #IHC and those that know when to order 😁🙏🙏
#PathTweetAward
Today’s #FNAFriday #CytoHisto correlation
🫧Physaliferous (bubbly) cells in myxoid stroma: a classic case of chordoma
(Top:DQ Below:H&E)
🟤(+) Brachyury
👉🏼#PathPitfall: when presenting as head/neck mass, stroma can lead to impression of pleomorphic adenoma
Today’s #FNAFriday #CytoHisto correlation
Giant cells in a background of bland mononuclear cells in a case of giant cell tumor
(Top:DQ Below:H&E)
👉🏼#PathPitfall: giant cell differential is broad!
Today’s #FNAFriday #CytoHisto correlation
🤔Deceptively bland metastatic melanoma-even bubbles in the background like you’d see in normal adrenal cortex!
(L: H&E R:DQ)
🟤(+) MART/45, SOX10
👉🏼#PathPitfall: adrenal cortex is positive for Melan-A!
Today’s #FNAFriday #CytoHisto correlation:
Pheochromocytoma:
(L: DQ, R: H&E)
👉🏼Polymorphic nuclei
👉🏼Abundant cytoplasm
👉🏼Loosely cohesive clusters
➕GATA3
A potential #PathPitfall when metastatic breast CA is in DDx of adrenal mass.
📌Pheos are cytokeratin NEGATIVE!
Today’s #FNAFriday #CytoHisto correlation:
Metastatic breast adenoCA to adrenal:
(L: DQ, R: H&E)
👉🏼Small nucleoli
👉🏼Cytoplasmic vacuoles
👉🏼Loosely cohesive clusters
➕GATA3
A common diagnosis with a potential #PathPitfall…
Impressive case, @JMcMahonG.
About 50% of these can be keratin+, an important #pathpitfall with carcinoma.
#PathTwitter
PRIMARY ANGIOSARCOMA OF BONE
Young adult developed a sternal mass with widespread metastases
Overtly malignant epithelioid / spindled cells with poorly-formed vascular lumina (notice the white "cracking" between the hyperchromatic nuclei)
#BSTPath #pathology #surgpath #MSKRad
Prostate biopsy xanthoma
➡️May mimic prostatic adenocarcinoma, especially foamy gland adenocarcinoma #pathpitfall
➡️ cd68+; epithelial markers -
#pathresidents #gupath
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