Top Tweets for #peace1
#ScienceLink #Madrid2026 #ESMO26 #PEACE1 #Abiraterona
En PEACE-1 (fase III), añadir abiraterona + prednisona al tratamiento estándar mantuvo el beneficio en SG en cáncer de próstata metastásico hormonosensible de novo.
⏰ Mediana de seguimiento: 7.7 años
📊 Población global
SG: 6.1 vs 4.6 años
HR 0.75 (IC 95.1%: 0.65–0.87; p=0.0001)
📈 Triplete vs doblete (n=710)
Abiraterona/prednisona + TDA + docetaxel vs TDA + docetaxel:
SG: 6.2 vs 4.4 años
HR 0.68 (IC 95.1%: 0.56–0.82; p<0.0001)
SG a 8 años: 40.3% vs 27.1%
🔎 SG por volumen metastásico
Alto: 4.6 vs 3.5 años (HR 0.67).
Bajo: 7.8 vs 6.2 años (HR 0.74; IC 95.1%: 0.51–1.05).
⚠️ En bajo volumen, la diferencia no alcanzó significancia estadística. No se detectó interacción entre el efecto del tratamiento y el volumen metastásico (p=0.56).
🔗 Leer/escuchar noticia completa: https://t.co/XNBYkhlXTC
Exciting phase 3 trials data in metastatic #ProstateCancer @myESMO #ESMO26 #ESMOAmbassadors #PEACE1 #Capitello281 @Silke_Gillessen @neerajaiims @OncoAlert @OncBrothers @PCFnews @shilpaonc @EAntonarakis @Parminder1699 @Uromigos @montypal @docjavip @drenriquegrande @cdanicas
#ESMO26: Adding capivasertib to abiraterone and adding abiraterone to standard care resulted in significant improvements in #ProstateCancer in the phase III CAPItello-281 and PEACE-1 #ClinicalTrials, as discussed by Elena Castro
🔗 https://t.co/OvTWVzKZll
#InsightsbyESMO
🤩 @OncBrothers highlighting 🔑 studies presented on Day 1 of #ESMO26
#BreastCancer
1. #NATALEE
2. #HorizonBreast06
3. #TALENT
#GIOnc
4. #RASolute302
5. #HerizonGEA01
#GUOnc
6. #KN866
7. #PEACE1
#OncTwitter #MedTwitter #bcsm #gism #gucsm @myESMO #MedX #MedEd #Oncology
Day 1 #ESMO26 highlights
Breast Ca
1. #NATALEE (update): Ribo Adj HR+
2. #HorizonBreast06: ADCs in mBC
3. #TALENT: NeoAdj TDXd HR+
GI
4. #RASolute302: Panc Ca
5. #HerizonGEA01: GEJ/Gastric
GU
6. #KN866: NeoAdj Pembro MIBC
7. #PEACE1: Abi in mHSPC
#OncTwitter @myESMO
1/8
#KarimFizazi with final OS analysis of #PEACE1 in met hormone sensitive prostate cancer treated w abiraterone +/- XRT, and +/- docetaxel. Important OS benefit across all subsets, median survival 6.1 yrs.
@oncoalert @myESMO #ESMO26
Long-term #PEACE1 data at #ESMO26 reinforce the survival benefit of treatment intensification in de novo mHSPC #KarimFizazi @OncoAlert
ADT + docetaxel + abiraterone vs doublet:Median OS: 6.2 vs 4.4 years
8-year OS: 40% vs 27%
Day 1 #ESMO26 highlights
Breast Ca
1. #NATALEE (update): Ribo Adj HR+
2. #HorizonBreast06: ADCs in mBC
3. #TALENT: NeoAdj TDXd HR+
GI
4. #RASolute302: Panc Ca
5. #HerizonGEA01: GEJ/Gastric
GU
6. #KN866: NeoAdj Pembro MIBC
7. #PEACE1: Abi in mHSPC
#OncTwitter @myESMO
1/8
🔈 Abstracts for #ASCOGU26
Poster: real-world outcomes mHSPC for triplet w/ Daro (#ARASENS) vs Abi (#PEACE1) by @CaPsurvivorship
👤 retrospective review 592 pts
➡️ pts receiving Daro triplet had improved outcomes over Abi triplet, inc. TTD, time to mCRPC/death, PSA R, OS..
Addition of RT to the primary in mHSPC #PEACE1
For the low volume population:
🔴No OS benefit
🟢rPFS benefit for patients treated with abiraterone
In the overall population:
🟢Reduction of the occurence of serious GU events
https://t.co/xZkLWqIUAq
☮️ The #PEACE1 trial identified five #prognostic #phenotypic #biomarkers, which @CedricPobel discusses at #ESMO24 @myESMO
👂 Listen here: https://t.co/r2ij4Ku1iQ
#ProstateCancer treatment revolution: radiotherapy and abiraterone in the spotlight of #PEACE1. Join @AlbertoBossial @GustaveRoussy and @CaPsurvivorship @DanaFarber as they discuss the results and significant benefits found in this study > https://t.co/CyDi7BiwRm
#ProstateCancer treatment revolution: radiotherapy and abiraterone in the spotlight of #PEACE1. Join @AlbertoBossial @GustaveRoussy and @CaPsurvivorship @DanaFarber as they discuss the results and significant benefits found in this study > https://t.co/CyDi7BiwRm
#ProstateCancer treatment revolution: radiotherapy and abiraterone in the spotlight of #PEACE1. Join @AlbertoBossial @GustaveRoussy and @CaPsurvivorship @DanaFarber as they discuss the results and significant benefits found in this study > https://t.co/CyDi7BiwRm
#ProstateCancer treatment revolution: radiotherapy and abiraterone in the spotlight of #PEACE1. Join @AlbertoBossial @GustaveRoussy and @CaPsurvivorship @DanaFarber as they discuss the results and significant benefits found in this study > https://t.co/CyDi7BiwRm
Role of prostate irradiation in de novo low-volume #mCSPC? New SOC “Quadruplet Txt”?
➡️Updated results of #PEACE1: Ph3 trial @AlbertoBossial @GustaveRoussy
Intensified txt improved:
✅rPFS
✅CRPC free-survival
❌No impact of RT on OS
Minimal added toxicity
#ASCO23 @OncoAlert
#ASCO2023 #PEACE1 Abstract LBA5000
Fase III que evalua el Rol de la #Radioterapia en ca de prostata metastasico de novo y bajo volumen, sensible a la castración. 1172 ptes randomizados 2:2
Prostate irradiation in men with de novo, low-volume #mCSPC: Results of #PEACE1, a phase 3 randomized trial with a 2x2 design. Presented by @AlbertoBossial @GustaveRoussy. #ASCO23 written coverage by @RKSayyid > https://t.co/9TKz4pFGSG #ProstateCancer @ASCO
Proud that Irish centres made a sig contribution to #PEACE1 and particularly @CUH_Cork where we randomised N=24 patients who placed their trust in us. Thanks to those who worked hard on this @KarenMolan Rafaela Carapeto @EricabennettRTT @UCCCancerTrials @cancertrials_ie #ASCO23
#ASCO23 Tweetorial on putting results of PEACE-1 in context. Here we go!
@ASCO @ASTRO_org @HimanshuNagarMD @DrRanaMcKay @AlbertoBossial @Prof_Nick_James @PCaParker
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