Top Tweets for #piio
New research featuring #PIIO member Dr. Steve Oghumu identifies myeloid-derived migration inhibitory factor (MIF) as a central regulator of the #MDSC #Treg #CD8โบ axis in #HNSCC & supports myeloid-targeted MIF inhibition as a strategy to reprogram the #TME & enhance responses to #ICB.๐ฌ ๐งฌ
๐https://t.co/r1qfZncuur
New research in @PNASNews reveals how deletion of the mitochondrial calcium uniporter (MCU) in #cancer cells boosts #anti_tumor #Tcell responses and slows tumor growth, highlighting a promising new target for #cancer_therapy. Congrats to #PIIO members @anjunma90, @GangXin1, Kai He, Bei Liu, @QinMaBMBL , @Zihai Li, and @wen_haitao! ๐ฌ๐งฌ
๐ https://t.co/deiQGI6WVW
New research by a team including #PIIO member @DCarboneMD examines factors linked to early progression with first-line #nivolumab + #ipilimumab in metastatic #NSCLC, offering insights that may help refine treatment strategies. ๐ฌ #Immunotherapy
https://t.co/GGD9uG1Drq
๐ Congratulations to @OSUCCC_James #PIIO Member Dr. Laura Chambers on receiving a third year of @theNCI K12 Oncology Program Scholar funding, recognizing her strong #CancerResearch progress, scholarly productivity and advancement toward research independence.
๐ Congratulations to #PIIO members on their new publication in @NatureComms! ๐
๐งฌ #Cancer is often most treatable before it spreads, yet identifying patients at risk remains a major challenge. This study introduces EmitGCL, an #AI-powered framework that combines multiple types of biological data to help identify patients at higher risk of metastasis and advance #precision_cancer_care.
๐ Congratulations to Xiaoying Wang, @Zihai Li, @DCarboneMD, @GangXin1, Lang Li, Kai He, @JordanKrull, and @QinMaBMBL on this outstanding achievement!
๐ Read more: https://t.co/55wwSdTnTe
๐ฏ #Precision_medicine is changing how we fight #LungCancer. @Pelotonia-funded researchers at @OSUCCC_James, including #PIIO members Drs. Junran Zhang, @Zihai Li and @QinMaBMBL, are studying a targeted strategy that could help deliver more personalized treatments.
๐ด @Pelotonia-funded #CancerResearch at @OhioState is advancing new treatments for #BreastCancer. #PIIO member Dr. Blaise Kimmel is testing an #immune_targeting approach for aggressive #TNBC , aiming for more precise therapies with fewer side effects.
New research featuring the #PIIO members @QinMaBMBL, @avilgelm & team suggest that senescence, specifically when induced by #Aurora_kinase_A inhibitor (AURKAi), can be harnessed to promote effector cell engagement in #immune_cold_tumors, thereby enhancing responsiveness to #cell_therapies. Check it out: https://t.co/dF6wN0Vp6K
๐ก New insights in #LungCancer research from #PIIO member Dr. @DCarboneMD & colleagues. Their Phase III analysis identified clinical & biomarker factors linked to early outcomes with first-line nivolumab + ipilimumab in metastatic #NSCLC, helping advance more personalized #immunotherapy. ๐ซ๐ฌ
Read more: https://t.co/iUpeUxFpqu
๐ Advancing #BreastCancer research! A new study from #PIIO members Dr. @NandiniAacharya, Dr. Ramesh Ganju, Dr. Jonathan Song, & colleagues reveals that induced electric fields (iEFs) remodel the #tumor_immune_microenvironment while limiting tumor growth and #metastasis. Findings support iEFs as a promising non-invasive immunomodulatory strategy for metastatic #TNBC.๐ฌโก Learn more: https://t.co/YhfwBPLefa
๐ข New Publication Alert! ๐ Congrats to #PIIO members @TMaceLab, @QinMaBMBL & colleagues on developing ParSlet, a prevalence-aware feature selection framework that improves microbiome biomarker identification, enhancing the reliability and reproducibility of disease-associated microbial signatures. ๐ฆ ๐ฌ Read more: https://t.co/qzryOJ8e7Z
๐ Get ready for an exciting #PIIO research-in-progress seminar on
KIR Acquisition During Human #NKCell Development
๐
July 8 | ๐ 12 PM | ๐ EAIC 130ย
๐ค Noah Koenigs, PhD candidate (Aharon Freud Lab)
Cutting-edge science + breakthrough insightsโbe there!
@OSUCCC_James
Congratulations to #PIIO/@OhioStateNeuro Recruit Dr. @NandiniAacharya on receiving her first @theNCI R01 Grant!
Her research explores how #glioblastoma hijacks peripheral trigeminal sensory circuits to establish an #immunosuppressive #tumor_microenvironment by instructing #tumor_associated_macrophages and driving #CD8โบ #Tcell dysfunction. By uncovering the molecular logic of this #neuroimmune circuitry, the work seeks to develop fundamentally new strategies to overcome #immunotherapy resistance through repurposing FDA-approved #nociceptor-modulating therapies.
@OSUCCC_James @Pelotonia
๐จNew Publications featuring #PIIO Member @NandiniAacharya. Two new @ImmunityCP papers co-authored by Dr. Nandini Acharya uncover fundamental mechanisms that shape #Th17 cell identity and function. These findings advance our understanding of how Th17 cells integrate environmental, metabolic, and intracellular cues to drive #immunity, #inflammation, & #cancer, opening new avenues for future #immunotherapies.
https://t.co/EJZxR0bNyt
https://t.co/eCubpiwY8p
Future cancer breakthroughs include inspiring #FutureScientists. ๐ฌ
Today, #PIIO postdoctoral researcher Dr. Jay Mandula (@Zihai Lab) welcomed @OSUCCC_James CAMELOT students to the @Pelotonia Research Center, sharing his journey into #CancerResearch and highlighting how #ImmunoOncology is transforming patient care.
Exciting news from @OSUCCC_James #PIIO๐
Congratulations to @A_Wieland_PhD on receiving support from the Elsa U. Pardee Foundation for his project, โTargeting intracellular oncoproteins with innovative antibody-based therapeutics.โ
Advancing the future of cancer immunotherapyโwell done! ๐งฌโจ
๐ Get ready for an exciting #PIIO research-in-progress seminar!
Discover how targeting PDE3A can supercharge #antitumor #immunity in #lungcancer.
๐
June 3 | ๐ 12 PM | ๐ BRT 115
๐ค Jay Mandula, PhD (Zihai Li Lab)
Cutting-edge science + breakthrough insights + and PIZZA โbe there!
๐จ DO NOT MISS! ๐จ
Join us for the #PIIO Distinguished Professor Seminar featuring Dr. Christian Jobin โ a global leader in #immunooncology & #microbiome research ๐๐ฌ
๐ Friday, June 5, 2026
๐ 12โ1 PM
๐ 115 BRT
๐ค Topic: โBacterial-derived small molecules in cancer: New therapeutic opportunities?โ
With cutting-edge insights into how microbiota shape cancer, this is a must-attend event! ๐ก๐ฅ
#PIIO #ImmunoOncology #CancerResearch #Microbiome #Seminar
๐ New research alert in tumor immunology! ๐ง ๐งฌ
๐งช Neoantigens and stochastic fluctuations regulate T cell proliferation in primary and metastatic malignant brain tumours
Using sequencing data from glioblastoma (GBM) and brain metastases (BrMET), #PIIO Member Dr. Jay Das and team reveal that:
๐น T cell clone sizes follow a heavyโtailed distributionโa few large clones, many small ones
๐น NeoantigenโTCR interaction strength and stochastic proliferation are key drivers of T cell expansion
๐น Higher T cell proliferation rates are predicted in BrMET vs GBM
๐น A validated mathematical model accurately predicts intratumoral T cell diversity
๐น The framework can even forecast peripheral T cell responses to neoantigen vaccines ๐ฏ
๐ A powerful fusion of immunology, sequencing, and stochastic modelingโopening doors for better neoantigen selection and brain cancer immunotherapy.
๐ https://t.co/R3zuaB38EI
#Immunology #CancerResearch #Neoantigens #Tcells #Glioblastoma #BrainMetastases #SystemsBiology #MathematicalModeling
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