Top Tweets for #polyQ
🚀 New research alert! Our latest study, in collaboration with international partners 🇨🇦🇩🇪🇫🇷🇵🇱 published @MolTherapy , explores a promising CAG-targeted brain-permeable therapy for #polyQ diseases like #Huntington’s & #SCA3. #neuroscience #GeneTherapy
📰 https://t.co/jk3qfu9EFg
Glad to share that our new, information-packed review is out: "Polyglutamine disease proteins: Commonalities and differences in interaction profiles and pathological effects" https://t.co/fD4X1fR0pP
#Huntingtonsdisease #proteomics #PPIs #PolyQ
New publication by @TiagoG_Neuro!! Are RNA-binding proteins #RBPs a fundamental target for polyq disorders?
Check out our new review that analyzes this question:
https://t.co/jGs1SrNbpt
@ABC_RInstitute @JNeurochem @ISN_society
#polyq #scas #rna #neurobiology #neuroscience
Expression of human #polyQ-expanded #huntingtin fragment in #Arabidopsis reveals mechanisms to prevent disease-related protein aggregation https://t.co/sJDvF6YOjp
🧵1/3
Exciting news!!🎉 We've published an article about free online database on polyglutamine diseases. 🧬https://t.co/TYo7cprQMa
@Algarve_ABC @Ualg
#neuroscience #PolyQ #glutamine #Spinocerebellarataxias #Ualg
It was fun today to stand on the other side of the podium and give my work in progress in person ! #sca7 #polyQ #usp22 #neurodegeneration #epigenetics #SAGAcomplex #DUBmodule #EMC
Scientific Symposia #FRM2023☀️Algarve ☀️
S17: Advances in Polyglutamine diseases research
🗣️Carlos A. Matos & @davidvcbrito
🇵🇹 @Algarve_ABC
Let's discuss all steps through the development of disease-modifying therapies!
#polyQ #neurodegeneration #therapy
Our latest preprint on the structures of Candida albicans Ras1, Cdc25 and their complexes is on @biorxivpreprint! More details below! @ProtCrys #Crystallography #SAXS #Candida #PolyQ
https://t.co/Dvf1obVYuX
📖Read our new review paper by Gkekas et al. "#OxidativeStress and #Neurodegeneration: Interconnected Processes in #PolyQ Diseases"!
👉Find more details at https://t.co/73MQt4fG01
#Antioxidants #polyglutamine #neuron
Increased levels of #mitochondrial import factor #Mia40 prevent #aggregation of #polyQ proteins in the cytosol
@Herrmann_lab and collaborators
https://t.co/9CbVROD7g3
Our latest study on #Huntingtin structure upon #polyQ expansion is out in @Structure_CP ! Congrats to @QiangGuo_EM and all co-authors for this great collaboration! 🤗 #MBExC
Together with @ruferbus @uniGoettingen. A fantastic collaboration with @uni_ulm @unikonstanz @Boehringer and @jingdongcheng @GeneCenter_LMU.
In this Comment Michele Vendruscolo and co propose that polyglutamine repeat expansion diseases could be caused by glutaminyl-tRNA depletion, leading to mistranslation of specific transcripts.
#polyQ #translation
@mvendruscolo14
@ChemCambridge
https://t.co/hFIKd4LCIb
Region stability is critical for features of #polyglutamine regions, while some features are taxa-specific
#CitedEnsembl @BMC_series https://t.co/9dizOZtuUu
#evolution #polyQ
Awesome to see this discovery out in @eLife from @mmppearce revealing a role for phagocytic glia in the prion-like transmission of aggregates across synapses in drosophila. Very cool! #polyQ #huntington #prion #neurodegeneration
Excited and proud to share our latest publication in @eLife showing that phagocytic #glia mediate transmission of #prion-like protein aggregates across #synapses in #Drosophila brains! @Kirbaee @DrosoPhilly
https://t.co/fCs3vR8yFJ
“Candidate compounds for lowering mutant HTT...#polyQ expansions...lowering levels of disease-causing proteins using autophagosome-tethering compounds.” Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds #huntingtonsdisease Nature https://t.co/PM5ajNiq5J
Prof. Edwin Chan and his research team discover new Inhibitors to restrain neurodegeneration. https://t.co/c9dXDIS3yM
#AQAMAN #polyQ #SCAs #neurodegeneration #MachadoJosephDisease #LifeSciences #CUHKScience
#polyQ - Verklumpungen in Zellen spielen bei der Huntington’schen Krankheit eine wichtige Rolle. Solche Proteinaggregate gibt es auch in Hefen, nur sehen die da anders aus. Neues Grundlagenwissen, dass für zukünftige Therapien wichtig werden könnte. https://t.co/ZbRLuper0W
Researchers from @MPI_Biochem and @HeidelbergU combined #CryoEM #tomography and #massspec to study #polyQ aggregates in yeast, which were surprisingly different from those found in mammalian cells. @PNASNews. #HuntingtonsDisease #ProteinAggregation https://t.co/VWlC3D6ZNd
Researchers from @MPI_Biochem and @HeidelbergU combined #CryoEM #tomography and #massspec to study #polyQ aggregates in yeast, which were surprisingly different from those found in mammalian cells. @PNASNews. #HuntingtonsDisease #ProteinAggregation https://t.co/VWlC3D6ZNd
#polyQ aggregates look quite different in #yeast and mammalian cells! Check out our latest papar @PNASNews https://t.co/pGmiClGoUB
#CryoEM #tomography #CryoET #massspec #HuntingtonsDisease #ProteinAggregation
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