Top Tweets for #postMONARCH
Now online in @JCO_ASCO #postMonarch from @KalinskyKevin @BianchiniGP @OncoAlert
Abemaciclib Plus Fulvestrant in Advanced Breast Cancer Following Progression on CDK4/6 Inhibition: Results from the Phase III postMONARCH Trial https://t.co/ARIH2rSbCJ
Breast Cancer Highlights from #ASCO24 w/ @ErikaHamilton9
- #RxPonder
- #postMONARCH
- #INAVO120
- #DB06
- #EMERALD
Full Int:
- https://t.co/ukNyzlPC8Y
- https://t.co/Q0WZyfiGBl
- Also on the “Oncology Brothers” podcast
#bcsm @ASCO #OncTwitter #MedTwitter @TargetedOnc
#ASCO24
#MONARCH high risk Ca Breast adjuvant Abema plus ET
🚨What if patient progressed on or after this ??
Ans is : #postMONARCH ?
PhIII, Abemaciclib + Fulvestrant vs Fulvestrant
- ⬆️PFS 6 vs 5.3 mos (HR: 0.73)
- Improvement in all subgroups but most benefit in pts that had been on CDK4/6i longer
Need better treatment in this setting ‼️
2. #postMONARCH: PhIII, Abemaciclib + Fulvestrant vs Fulvestrant after progression on CDK4/6i + AI in HR+ mBC:
- ⬆️PFS 6 vs 5.3 mos (HR: 0.73)
- Improvement in all subgroups but most benefit in pts that had been on CDK4/6i longer
- Roadmap by @oreganruth @WilmotCancer
4/10
PostMonarch: Abemaciclib after progression on CDK4/6 inhib shows 27% reduction in PFS. All subgroups, all biomarkers seem to benefit.
Valuable in the current landscape; sets the stage for EMBER-3 w/oral SERD + CDK4/6 and allows maximal ET in MBC
#ASCO24 @OncoAlert (COI/author)
Day 2 #ASCO24 highlights:
1. #INAVO120: Inavolesib mPIK3CA HR+ LA/mBC
2. #postMONARCH: Abema + Fulvestrant after CDK4/6i in mBC
3. #EMERALD: Eribulin + HP HER2 mBC
4. Favorable/V Favorable mRCC
5. #DREAMM7: BVd 2L Myeloma
#bcsm #lcsm #mmsm #OncTwitter @ASCO
1/10
#ASCO24 #postMONARCH
Abemaciclib+Fulvestrant como opción ante progresión a iCDK4/6 no influenciada por biomarcadores!
💥 mayor efectividad en enf no visceral
💥 mayor efectividad en poblac sensible
💥 Abema mejoró PFS por BICR y por investigador
👏🏻👏🏻👏🏻👏🏻
#postMONARCH showed modest (at best!) benefit of sequential CDK4/6is
mPFS: 6.0 mo vs 5.3 mo
6m PFS: 50% vs 37%
Benefit mainly relevant in patients exposed to prior palbociclib and with no visceral disease
#bcsm @oncoalert @OncBrothers @VJOncology @KalinskyKevin
@KalinskyKevin #postMONARCH- fulv +/- abema after AI+ CDK
*️⃣ 5.3 vs. 6.0 mo w/ abema, HR signif, magnitude of benefit smaller in local assessment
⏺️ BICR - 5.6 vs. 12.9 mo, investigators overcall PD?
#️⃣No real 🔼 w/ prior CDK duration
#bcsm
#ASCO24
(COI-I'm an author)
A tiebreaker in CDK after CDK #postMONARCH and of course, can't go through any oncology conference today without the hot topic of #ctDNA. #bcsm #ASCO24
Also, at #ASCO24 the long awaited #postmonarch trial (to extend or not to extend—that is the question) and more detail on how we may incorporate ctDNA into personalized care @KalinskyKevin @LoiSher
Also, at #ASCO24 the long awaited #postmonarch trial (to extend or not to extend—that is the question) and more detail on how we may incorporate ctDNA into personalized care @KalinskyKevin @LoiSher
PACE:Palbo after palbo=no improved PFS compared to FULV alone @elmayermd
💡On heels of @KalinskyKevin MAINTAIN, adds to importance of #postMonarch & biomarker analysis
🔎PD-L1 inhibitor=interesting signal
🎯 w/changing landscape in ESR1 & PIK3CA tx, how to consider seq? #SABCS22
.@KalinskyKevin #MAINTAIN lays groundwork for extending CDK4/6 after CDK4/6 while switching endocrine backbone. Will be tested in #postMonarch trial. ESR1 mutations may be a useful decision tree. #ASCO22 @OncoAlert
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