Top Tweets for #pselectin
🔍 🌟 @MarcCarrier1 during @ICTHIC emphasizing fresh perspectives to prevent recurrent DVT in cancer patients.
Consider previous #VTE, #ECOG and cancer such as #lung, #GU and #pancreatic.
Monitoring #CRP, #ddimer, and soluble #Pselectin levels .
Ideas for new @isth studies.
Article✍️A non-human primate derived anti-#Pselectin #glycoprotein #ligand-1 antibody curtails acute #pancreatitis by alleviating the #inflammatory responses. Anti-human PSGL-1 antibody (RH001-6) was generated. From Dr. Yang @PekingUnionMedicalCollege.
https://t.co/0s86Co3hvC
In an @nih_nhlbi #RCT, #crizanlizumab was tested in 🛏️pts w #COVID19: https://t.co/7zh2gYmY12
In the @CircAHA Editorial, @PHRIresearch @McMasterU we summarize the lessons learned from #Pselectin deACTIVation. Kudos to trialists! @scottdsolomon
Link here👇
https://t.co/5quYgyRVLm
#ACTIV4a results for crizanlizumab for pts w #COVID19 by Dr. Lowenstein @HopkinsMedicine @isth #ISTH 2023, sim pub in @CircAHA. Bottomline: It doesn’t work. ?if harm. Editorial by Dr. Eikelboom & I to come soon. #pselectin
https://t.co/7zh2gYmY12
@marinarubio1978 share exciting results about new #MCA #intracerebral #aneurysm 🐭 model & molecular #MRI method using #microsized particles to predict rupture 🧠⚫️ #BAMs #VCAM1 #PSelectin @BbCaen @ViviensLab1
Thanks @hubert_armand @bourcierromain1 for inviting us to the #FJA2023
What role does #thromboinflammation play in #DVT resolution and clinical outcomes? Our study provides novel insights regarding #FactorXI, #Pselectin and #GPVI! Published #OpenAccess in @ThrombosisRese1
https://t.co/TqkX8SuYP8
#deepveinthrombosis #thrombosis #bloodclots
46) . . . that both #Pselectin levels and mean platelet volume (#MPV) assays indicated no evidence of ⬆️platelet activity or "sensitivity" after reversal:
@LucyKornblith @MichelleNgGong @lana_wahid and so many others - A reminder that @ACTIV4a is also investigating #Pselectin inhibition and #SGLT2i in hospitalized patients with #COVID19 @MkosiborodMD @scottdsolomon @ankeetbhatt
Interested in learning more about #Platelets, #Pselectin & systemic #Inflammation in relation to #MetabolicSyndrome & #CognitiveDecline in #Schizophrenia? Dr. Ola Okusaga will present his research on this topic today at 4 pm.
Don't miss today's #CTRID #research #seminar series by Dr. Ola Okusaga, "Platelets, P-selectin, & Systemic Inflammation: Links w/ Metabolic Syndrome & Cognitive Decline in Schizophrenia" Thur Jan 13 at 4PM CST!
@bcmhouston @VAHouston @bcmfromthelabs
Info: https://t.co/PsrC8iaBP4
Our paper on coagulation markers and #Thrombosis in #COVID19 is published in @AjHematology. ❗️#Pselectin is a candidate early marker of venous thromboembolism, even in combination with #Ddimer.
@semmelweishu @MGH_RI
31 coagulation markers evaluated using biorepository data on 306 patients w/ #COVID19
🩸 VWF & P-selection higher, & ADAMTS13 & Factor VII levels lower in patients who developed VTE.
Plasma P‐selectin is an early marker of thromboembolism in COVID‐19
https://t.co/ovACkpdvw4
#BDNF #CAD #platelets #plateletactivation #PSelectin #Endothelium #dementia #AlzheimersDisease
https://t.co/8NT0GYo6en
#Pslectin blockade & #SickleCellDisease: a prime example of bidirectional translational research, starting with the observation of the abnormally-shaped RBCs & ⬆️expression of #Pselectin that have now translated into new therapies -- Marion I. Barnhard Memorial Plenary #ISTH2021
PL 02 Marion I. Barnhard Memorial Plenary Lecture "From Bench to Bedside: #PSelectin Blockade in #SickleCellDisease" showcased updates on the #SUSTAIN #crizanlizumab trial, new safety data, and ongoing clinical trials!
Next up, @marinacamera_ will present our extensive and systematic review of platelet activation markers as predictors of cardiovascular events. The group read through 885 papers for #pselectin only! #ISTH2021
And we're live at the #ISTH2021! Paolo Gresele is presenting our individual-level #metaanalysis of the @isth bleeding assessment tool (BAT) in inherited platelet disorders. 6 different studies contributed key data on the use of ISTH BAT in patients with #IPD.
9/20
Using custom msAb-N9, we showed that we could significantly decrease adhesion between HPAECs and #TRAP-activated platelets, suggesting the #NEDD9-#PSelectin binding interaction was important for platelet-endothelial interactions, at least in vitro.
8/20
Using immunoprecipitation, LC-MS, & microscale thermophoresis, we identified the substrate domain of #NEDD9 binds directly to #PSelectin. We then generated a custom-made monospecific polyclonal antibody (msAb-N9) targeting the putative binding region b/w #NEDD9-#PSelectin.
#platelets from #COVID19 patients had ⬆️ #Pselectin, platelet-neutrophil, monocyte, & T-cells
➡️platelets aggregated faster & ⬆️spreading on #fibrinogen & #collagen
⬆️in platelet hyperreactivity due to ⬆️MAPK pathway activation & #thromboxane generation https://t.co/JqVLzQDceo
Our latest article investigating the role of #Pselectin ligand #PSGL1 in #OSA. @ManchesterBRC
https://t.co/ylgAsupWip
#ASH19 | #MPNSM MPN Education Session. @bradyleestein presenting novel factors in MPN-related thrombosis ➡️ identification of new pathways & factors needing further investigation including #Pselectin and #NETs = neutrophil extracellular traps
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