Top Tweets for #repeatome
John Sedivy at #SenescenceInVivo: a large portion of our genome is the #repeatome, including the various retroelements. They are involved in cancer and aging in part through activating #interferon responses. A new role for anti #HIVDrugs? #Vienna #WiggersBernard @LBG_SHoW @BrownUniversity
We performed an integrative analysis of whole genome & transcriptome data to understand the co-evolution of transposon activity, #repeatome transcription, innate immunity & tumor evolution in a rapid autopsy evolutionary cohort of PDAC patients created by @ciacobu
L1 has been implicated in events such as DNA damage and innate immunity, and p53 mutations are a critical event in cancer evolution. Our work is an example of how multi-modal models built on mechanism can bring further insight to the role of the #repeatome in cancer.
Thanks @rome_tx for the kind welcome! It’s been an amazing month so far and I am grateful for this opportunity to contribute to the exciting research as a new ROMAN! #RomeSweetRome #RepeatOME #immunology
How satellite repeat viral mimics can impact the immune microenvironment. Officially out in @jclinicalinvest with @rlporter18 @sunsiyu1 @davetingmgh @MGHCancerCenter @MSKCancerCenter
Tweetorial for early version:
https://t.co/IkByFP7r0V
#HSATII #viralmimicry #repeatome
Satellite repeat RNA impacts the immune microenvironment in ovarian cancer: https://t.co/SFU4K6tcVH
@davetingmgh @bengrbm
@harvardmed @MSKCancerCenter
#Oncology
Congrats @davetingmgh & @bengrbm! Your important work is shedding light on the key role of repeat biology in cancer. #repeatome #darkgenome #cancerresearch #innovation
@davetingmgh found HSATII that was overexpressed in many tumors in 2011 a classic paper. We later showed HSATII expressed CpG motifs in a way that's unusual for the human genome and more commonly associated with non-human pathogens – ie #viralmimicry
https://t.co/5A4Y8zHuLK
Great interview with @davetingmgh in the Harvard Gazette on our recent work in @CD_AACR using HIV drugs to disrupt the #repeatome in colorectal cancer
👇👇👇
https://t.co/ggUkUWkpVm
Great article by our scientific co-founders, D. Ting & @bengrbm demonstrating the impact of inhibiting endogenous reverse transcriptase & disrupting repeat function in CRC. 3TC treatment in metastatic CRC Ph.2 trial resulted in clinical benefit for 9 out of 32 patients.#repeatome
Excited for #ROMETx to be named one of 2021's 10 Start-ups to Watch by @cenmag! We may be biased, but the #repeatome is certainly a space worth watching! We are honored to be included among such incredible companies. Read more here: https://t.co/tGSIeoK40A
@grahamserwin @daforerog @KathleenHBurns @mgymrek @khmiga @twang5 @PacBio @generegulation A fantastic line-up of speakers in this exciting and rapidly expanding field! #TandemRepeats #repeatome
Wow, impressive work from Po-Ru Loh, @s_mccarroll and colleagues identifying multi-allelic #VNTRs with strong effects on multiple traits in #UKBB https://t.co/HEBJTxVubQ
Beautiful allelic series between # rpts and phenotypes. Many more variants in the #repeatome to be found!
SPECTACULAR paper on phenotypic effects of variable number tandem repeats (VNTR) imputed in the full UKBB (N=500k) based on haplotypes inferred from 50k exomes. Papers like this is why I love human genetics.
https://t.co/eEBz929oXh
@ileena_mitra @NatureNews Many thanks and congratulations to you, @mgymrek and the rest of your co-authors on this excellent Nature paper! These approaches for genome-wide exploration of tandem repeats should be applied to many common human disorders and traits. #TandemRepeats #repeatome #autism #genetics
Furthermore, these new discoveries should encourage researchers to explore tandem repeats genome-wide for a range of common disorders, including brain disorders such as schizophrenia, depression, bipolar disorder, ADHD, OCD and Alzheimer’s disease. @TheFlorey @unimelb #repeatome
Mitra et al (Nature) find associations between tandem repeats and autism. Together with Trost et al (Nature) this provides new insight into the genetics of ASD. Repeat DNA expands our understanding of autism spectrum disorder https://t.co/v1ksudgLku. @TheFlorey @unimelb @mgymrek
@Gianina_Natoli @Brain1878 @sarah_beecroft @MiriamNZNMD @benweisburd Congratulations! The tandem repeat disorders field continues to rapidly expand! #repeatome
#ROMETx is honored to be included in @FierceBiotech’s “Fierce 15” biotechs of 2020! Thanks to our growing team of ‘Romans’ and the founders, collaborators, advisors and investors working with us to harness the power of the #repeatome! https://t.co/zFSa00p2cR
Excited to see @TheEconomist explore the role of viruses in human health, including the integration of viral DNA into the human genome giving rise to “repeats.” #ROMETx is working on the next chapter of this story - exploring and conquering the #repeatome.
Viruses cause pandemics. They also demonstrate natural selection at its most dramatic. Our cover this week looks at how viruses shape the world https://t.co/es2HvmlWOK
Excited to welcome my friend and colleague Dennis Zaller, Ph.D. as Chief Scientific Officer of #ROMETx. Look forward to unlocking the secrets of the #repeatome with our newest Roman! https://t.co/NC0iQtBhfY
@ldtimmerman Thanks for giving me the opportunity to share my story from the beaches of Rio de Janeiro to Genetown, MA. I hope it will inspire young women to reach for the stars. #repeatome, #conquerdisease, #leanIn
From Rio to ROME: Rosana Kapeller on The Long Run podcast, talking about drugs for the 'repeatome.' @KapellerRosana https://t.co/wy9ETffDqC
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