Top Tweets for #viral_evolution
@Laurie_Garrett This is interesting - hypothesizes that SARSCoV2 may have emerged from pangolins to humans as a less pathogenic virus, then become more severe. It consider as far back as 2017 for spillover.
#epidemiological_dynamics #transmission_dynamics #viral_evolution #zoonosis #spillover
Shell Disorder Analysis Suggests That Pangolins Offered a Window for a Silent Spread of an Attenuated SARS-CoV-2 Precursor among Humans
8/13/2020
“precursor..human population in 2017 or earlier, w/subsequent slow & silent spread..”
https://t.co/qWDRNnSTji
H/T @Brandon75311349

“The rules behind #zoonosis are very poorly understood, & we have some really exciting work underway in which we’re building predictive models to understand the variables in the environment that can lead to these #spillover events.”
#viral_evolution #host_pathogen
Genome of Alaskapox Virus, a Novel Orthopoxvirus Isolated from Alaska - PMC
8/11/2019
#orthopoxvirus #poxvirus ##NIH #monkeypox #cowpox #SARSCoV2_timeline 2015 #recombination #viral_evolution #emerging_pathogens #Old_World_Poxvirus #OPXV https://t.co/srNC57IaUU
Great TEDtalk on systems dynamics
“Systems Thinking is Not Optional: Lessons From a Pandemic”
#pandemic_dynamics #viral_evolution #unintended_consequences #biodiversity
SARS-CoV-2 infection and persistence throughout the human body and brain
12/20/2021
#SARSCoV2_timeline #autopsy #SARSCoV2_pathology #viral_persistence #viral_evolution #intrahost #viral_diversity #mixed_infections
https://t.co/kPvJoGI9TU
@BubblebeeRed @AstroKatie @HelenBranswell @bridget857 Something they didn’t really tell us is that the length of the transmission chains & speed with which passage from host to host occurs are meaningful to #viral_evolution. The more we interrupt the virus transmission, the less chance it has to mutate (from my non-expert read).
“It’s like a viral yo-yo”
#viral_evolution #sarscov2_pathology #variants #Delta #Omicron #BA1 #BA5 #TMPRSS2 #tropism #SARSCoV2_timeline #Spring2022 #Summer2022 #pandemic_dynamics
@Mike_Honey_ @EricTopol BA5 has switched tropism again to use TMPRSS2. It’s like a viral yo-yo. Here’s what Delta, BA1 and BA5 look like in cells with TMPRSS2 when exposed to positives samples and left for three days.

“…until their resistance is lowered or the organism becomes so virulent that they cannot withstand its invasion.”
#viral_evolution #immune_suppression #EncephalitisLethargica #historical_precedent
@ThePoiema @briebriejoy @JeffDSachs There probably wasn’t a lab leak in late 2019 in Wuhan, because sarscov2 was probably circulating well before then. “Lab Leak VS Wet Market” is a #false_dilemma.
There are other possibilities, like undetected transmission & #viral_evolution in people pre-2020. #Sarscov2_timeline
#pandemic_dynamics #transmission_dynamics #R0 #viral_evolution
“Even if R is below 1 in mostly susceptible population, can still see large ‘stuttering’ outbreaks occasionally.”
[#NorthAmericanMERS (?)]
Even if R is below 1 in mostly susceptible population, can still see large 'stuttering' outbreaks occasionally. So important to disentangle effects of:
A) chance events
B) change in virus characteristics (e.g. via evolution)
C) change in population in which virus spreading.
4/
@NinjetteTheReal And whatever’s happening here
https://t.co/o3H0Q4wLjl
#toxin #viral_evolution #venom #spider #arachnid #black_widow #DNA
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