Donghoon Lee

Assistant Professor @IcahnMountSinai interested in #Alzheimers #PsychGen leveraging #SingleCell #CompBio #ML views my own

[Donghoon Lee @hoondy]

I’m thrilled to share one of the largest single-cell transcriptomic atlas of the human DLPFC with over 6.3M nuclei from 1,494 unique brain donors. Collaboration with @MKoutrouli Nick @g_e_hoffman @JaroslavBendl John @panos_roussos and #PsychAD Consortium

https://t.co/JdvKkTbeHZ

[Center for Disease Neurogenomics @CDNeurogenomics]

We created a cross-disorder atlas of the human DLPFC exploring inter-individual & cross-disorder transcriptome variations. We aimed to provide a foundational framework for targeted, cross-disorder treatments that address the molecular complexity of brain dysfunction. #PsychAD

[Rush Alzheimer's Disease Center @rushalzheimers]

Congratulations again to the award recipients of the third annual Martha Ondrey Junior Investigator Prize! #ROSMAP2026 #ROSMAP26

[Rush Alzheimer's Disease Center @rushalzheimers]

With the generous support of Frank Ondrey, MD, PhD, the RADC is pleased to present the 2026 Martha Ondrey Junior Investigator Prize to Donghoon Lee, PhD. Dr. Ondrey presented the award.

[Panos Roussos @panos_roussos]

Now out in @Nature: Biological insights into schizophrenia from ancestrally diverse populations.

With @MountSinaiPsych @SinaiBrain @SinaiGenetics @CDNeurogenomics @POPGEM_Lab #MillionVeteranProgram and collaborators across consortia.
Read: https://t.co/qPMW9EQtMO

[Jennifer Guerriero, PhD @JennGuerriero]

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.

[WOBKEY Official @WOBKEY1]

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Good luck!😉

New event is always on its way!
#giveaway #WOBKEY #Zen65

[Donghoon Lee @hoondy]

Amazing work by @TerezaClarence @JaroslavBendl @XuanCao09514634 and many co-authors!

[Center for Disease Neurogenomics @CDNeurogenomics]

Excited to share a new study mapping postnatal human brain development with multi-omic single-nucleus data https://t.co/92ZB9l0Nus
🧠 101,924 nuclei | 4 regions | 10 donors | 5 key stages
🧬 Cell-type GRN linking GWAS loci to 1,149 genes
⚡ Oligodendrogenesis & brain disorders

[Cheen Euong Ang @hhhcce]

I want to acknowledge the supports from @panos_roussos @ReneKahn @EricJNestler and many many members from the @CDNeurogenomics and @SinaiBrain to get the lab up and running. Please visit https://t.co/zej1SKvx8K for openings.

[Center for Disease Neurogenomics @CDNeurogenomics]

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at https://t.co/BhkOaqATQV

🧵 Found out summary of papers below👇

[Donghoon Lee @hoondy]

To all #ASHG24 attendees, I’ll be speaking during “Mapping the Brain in Health and Disease” session today. Come join me & hear about the population-scale single-cell cross-disorder atlas.

📍 Room 501
🗓️ Nov 6, 10:45 AM (MT)

[Donghoon Lee @hoondy]

Excited to start day 2 of #ASHG24

[Cameron McAlpine @cam_phd]

A wonderful summary of our work!

[Cameron McAlpine @cam_phd]

We are delighted to share our latest findings today in @Nature. We describe cardiogenic regulation of sleep after cardiac injury.

“Myocardial infarction augments sleep to limit cardiac inflammation and damage”

https://t.co/ip6psmJBZ2

[Sebastian Seung @SebastianSeung]

Wow. Hopfield model and Boltzmann machine.

[Mount Sinai Psychiatry @MountSinaiPsych]

Under the auspices of the PsychENCODE Consortium, Dr. @panos_roussos and his colleagues are changing the field with single-cell analyses of brain tissue with schizophrenia and unraveling regulatory mechanisms of brain disease. via @ScienceMagazine
https://t.co/rj8fOTbK93

[Center for Disease Neurogenomics @CDNeurogenomics]

The Center for Disease Neurogenomics (CDN) had a successful retreat day. The year 2024 marked the 10-year anniversary of the lab, and we have grown to 67 members. #CDN #retreat

[Friedman Brain Institute @SinaiBrain]

Genetic regulation of cell type–specific chromatin accessibility shapes brain disease etiology - Biao Zeng, @JaroslavBendl, John Fullard, @g_e_hoffman, @Panos_Roussos, et al. @sciencemagazine https://t.co/7FAqH9xhEL

[Friedman Brain Institute @SinaiBrain]

PRESS RELEASE: Working under the umbrella of the PsychENCODE Consortium, a team of @IcahnMountSinai scientists, lead by @panos_roussos, has uncovered new insights into molecular biology of neuropsychiatric disease. #ArtoftheBrain image by @jsj8duke 👉https://t.co/79cz4dxfHD

[Panos Roussos @panos_roussos]

Recent review article on neuropsychiatric symptoms in Alzheimer's disease highlights the vast areas still to explore and understand, aiming for meaningful improvements in patient treatment
https://t.co/u722XGVYYH

[Panos Roussos @panos_roussos]

Excited to have the #PSYCHENCODE24 papers out. Thanks for the support of @NIMHgov and the effort of multiple colleagues to bring this product to the finish line! https://t.co/O7IS8mOV56