Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺

Biotech entrepreneur. Toxicologist. Economist. Plus a veterinarian! Obsessed with taking the coolest science into clinical PoC.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@dannycheng2022 As a Hong Kong resident, I find the house prices here simply stupid. The calculus makes no sense - for the kind of money needed for buying, you could have a much much better standard of living almost anywhere else in the world.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@SnupSnus 'HeartSheet' was approved back in 2015 in Japan on n=7 data. There are a few other similar examples there.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@gotravelyourway A tiny warm champagne on Air China last week was unpleasant, but not a dealbreaker. Instead, if I see signs of organizational dysfunction - when something goes wrong and rescheduling, rerouting, or getting any help becomes impossibly difficult, that’s hasta la vista baby.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@therealRYC Great post! It's too bad there's never been a truly potent & selective full M1 agonist that could help to show how M1, by far the most prominent subtype in all brain regions, drives efficacy (xanomeline is a decent M1 agonist but only a partial M4 agonist).

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@RNAiAnalyst Such associations have been observed before (e.g. Exanta) but the positive predictive values have always been too low for HLA screening to be useful in clinical practice (e.g. 2-4*higher risk).

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

The NHP shortage has been brewing for a while, great to have this story out @AmberTongPW #china #biotech https://t.co/M5sPMiNyW8

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@JSheltzer @genophoria With enough determination almost anything can be made to look like a cancer cure in mice. I remember particularly impressive data on blueberries.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@michaelbellart Try Sanlitun Soho, Central Park, Fuli Cheng, Shiqiao Guomao

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@Jack_O_Meara @MattyKirsh Respectfully disagree. Double-stranded RNAs are definitely more neurotoxic than ASOs. That explains all those i.t. admin siRNAs that have quietly disappeared from pipelines over the years...

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@AppleHelix Insilico Medicine is side hustling as a CRO (PandaOmics etc.).

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@bradloncar I’ve been traveling by train here in China so much that some of the China Railways staff have started to recognize me, can’t beat that 😂 (~2 million employees)

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@JAC0BSTERN @sytses Beijing hospitals are great - you can walk into a world-class clinic and walk out with an MRI an hour later for ~$50.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@chuminhua432 Important clarification is that this is an extension to their "PandaOmics" that they've been selling to clients for years as a CRO service (as a sort of side hustle to make extra $).

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@SariArhoHavren The use of the North Pole route is also limited due to cumulative cosmic radiation exposure limits for flight crew.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

Happy to see my old “baby” - certepetide that I took from academia to Ph2 - to get a new life. And love the name stays Finnish: lisätä = to increase, kuva = image. 🇫🇮 https://t.co/UtItbXBAQT

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

I’ve just published a long-form piece on Chinese CROs in 2026 - how the industry has matured, what “China speed” actually means in practice, and where biotech sponsors still need to be careful. I hope this is useful. https://t.co/2twXxZgsCg

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

I remember chatting with my tox/safety pharm colleagues ~20 years ago how caffeine might be beneficial for heart electrophysiology by desensitizing & stabilizing ion channels / signaling systems. And now the data are FINALLY catching up 😄

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

A research hospital in Nanjing 南京 currently has more than 1000 active IITs…

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

Attending the BioCentury China Healthcare Summit in Shanghai. Super busy. The FOMO levels are sky high. Never been a better time to be based in China.

[Harri Järveläinen 🇫🇮🇺🇸🇨🇳🇦🇺 @hulivili]

@therealRYC The lead candidate seems to be xanomeline with a very minor chemical modification. Pharmacology wise looks similar too, the assays can be very fluffy here!