Fellow,🩸& 🦀 Memorial Cancer Institute| IM alum @NYCHHC/Lincoln| alum @CMULNigeria| medical education| 🦀 prevention| creative writing| Blaugrana. Views = mine
@IAmOluwanimilo Really? Why? PSV were Dutch champions last year and are currently top of their league. The loss to the Dutch champions isn't the problem. Because PSV can hold their own against anyone. The problem is the way and manner the loss happened. Such a poor team performance at the back.
“I would teach a medical student something and it seemed to trigger a lightbulb in their head, and I thought, I wish someone else had told me about that, so I just started sharing more widely.”
Profile: @AaronGoodman33 aka Papa Heme
@csoncol@UCSanDiego
https://t.co/NO8et7XRHB
Just out in the Journal of Clinical Oncology! @JCO_ASCO
A paradigm changing paper on MGUS and Smoldering Myeloma @FrancescoMaura4
And it’s Open Access!!
https://t.co/svHThmjiCm
KEY FINDINGS:
1) We identify for the first time myeloma defining genomic events to differentiate biologic premalignancy (genomic MGUS) from biologic malignancy (genomic Myeloma).
2) We find that most of smoldering myeloma and almost all of high risk smoldering myeloma is biologic malignancy with genomic features indistinguishable from active myeloma
3) We show that some myeloma defining genomic events are also associated with high risk of progression resulting in a genomic model of risk stratification of Smoldering Myeloma.
4) We show that combining the genomic model (genomics) with the IMWG2020 model (clone size) provides a better risk stratification than either alone.
5) We provide the code and information where if you have access to sequencing you can run this yourself to determine whether the patient has genomic MGUS or genomic Myeloma
This is a major collaborative international effort with top centers and researchers pooling data so we can finally address these important questions. @FrancescoMaura4@szusmani@Leif_Bergsagel@myelomaMD@DrOlaLandgren@DrKrinaPatel@Myeloma_Doc@Rfonsi1@DrGarethMorgan1@MSKCancerCenter@MayoClinic@SylvesterCancer@Perlmutter_CC and more.