Mo Ameen

PhD student @stanford interested in pharmacogenomics, cardio-oncology, single-cell (epi)genomics, iPSC, big data, machine learning. My views are my own.

[Surag Nair @suragnair]

Excited to share work with co-first author @immoameen. Gene regulation is a delicate balance b/w cis-regulatory sequence & TF conc, but these components are often studied in isolation. Reprogramming is a fantastic system to study their interplay 1/16

https://t.co/eI6EzHNLRT

[Anshul Kundaje @anshulkundaje]

Check out our latest work led by @suragnair & @immoameen using neural nets to dissect the interplay of TF stoichiometry, motif affinity & syntax in fibroblast reprogramming to iPSCs. Several fascinating insights from the models.
https://t.co/lMAZiRcLCY
Tweetorial coming soon 1/

[Simon Shen @twinsmc18]

Happy to share our paper out in @CircAHA, in which we developed a novel and robust protocol to generate cardiac pericytes, the most enigmatic cell type in the heart, from hiPSCs. we hope it will help better understand the role of cardiac pericytes in microvascular dysfunction.

[Ioannis Karakikes @IKarakikes]

Excited to share our latest work using phenotypic screening to identify novel therapeutic targets for DCM @EHJ_ed, led by the talented @IsaacPerea
https://t.co/5AYMtfCF82

@StanfordCVI @SnyderShot @salkinstitute @StanfordCTSurg @StanfordMed

[David R. Liu @davidrliu]

Today we report in @CellCellPress our new PE4max and PE5max prime editing systems that we first presented at @CSHLmeetings in August. 1/12
https://t.co/BnlnqD5hml

[Google DeepMind @GoogleDeepMind]

Published today in @naturemethods together with colleagues from @calico: Enformer - a transformer model that has led to greatly increased accuracy in predicting gene expression from DNA sequence.

Blog: https://t.co/21zIewaiKR
Paper: https://t.co/Bg1gPp4AWe 1/

[Cell @CellCellPress]

Out now! A single-cell atlas of gene expression and chromatin accessibility of the human developing cortex during mid-gestation identifies prioritized mutations for Autism Spectrum Disorder
#neuroscience #developmentalbiology
@PascaStanford @Stanford
https://t.co/12TyeFHTtC

[Paul Burridge @pwburridge]

Proud to finally have our paper on RARG agonists to prevent doxorubicin cardiotoxicity published in @CellStemCell. https://t.co/72exLZcyU2. We're hiring postdocs (NIH-funded) if you like to do more of this type of work! https://t.co/rnTQs08ZRv @NUFeinbergMed

[Roger Foo @rsyf2]

https://t.co/9b6dVeWdyt very glad that our review on Cardiac Enhancers is out. The @TheFooLab will be paying close attention to development of enhancer targeted disease therapies. Exciting stuff... @NUSMedicine @CvdNus @astar_gis https://t.co/sdComiXo16

[Steve Stewart-Williams @SteveStuWill]

One of my all-time favourites. Stare at the red dot on the woman's nose for 30 seconds, then look at an empty wall while blinking quickly. Promise it's worth it... https://t.co/jsmr9VtTjj

[Circulation @CircAHA]

#OriginalResearch: The unfolded protein response as a compensatory mechanism and a potential therapeutic target in PLN R14del Cardiomyopathy. Learn more here: https://t.co/0wxDJYe7EL #AHAJournals @IKarakikes @StanfordMed @StanfordCTSurg
@StanfordCVI @RMUtrecht @CirculatHealth

[Daniela Witten @daniela_witten]

Finally --- the 2nd edition of ISLR is out!!!!🥳🎉🪅🍾

Well, sort of. 🙄It's "published", but due to shortages in the global paper supply, hard copies won't be available for a bit longer 😢😭🤦‍♀️

You can pre-order a hard copy from Springer/Amazon, & **download the pdf today**! 1/

[Joy Wu, MD, PhD @JoyYWu]

OK I found my words. I am howling with rage tonight at the rising tide of violence and hate crimes directed towards Asians in America, punctuated by the horrific shootings yesterday in Georgia at 3 Asian-owned business that claimed 8 lives, including those of 6 Asian women.

[Ryan Corces @ryancorces]

ArchR is now online at @NatureGenet! A one-stop shop for all of your scATAC-seq data analysis needs. Led by @JeffreyGranja and in collaboration with @HowardYChang and @WJGreenleaf. Analyze >1.2M cells on a laptop!
https://t.co/38D8SHbIER
https://t.co/VT7lj7O9Zo

[Anshul Kundaje @anshulkundaje]

Base-resolution models of transcription-factor binding reveal soft motif syntax
https://t.co/fvqtBQOi3P

Its ALIVE!! 1/

[Leland McInnes @leland_mcinnes]

The latest version of umap-learn is now out. Version 0.5 includes some major new features, including ParametricUMAP, DensMAP, AlignedUMAP, model composition, and model updating. Thank you to everyone who contributed! 1/14

[Sarah Pierce @Sarah_E_Pierce]

We are excited to share our new multi-omic method, Spear-ATAC, which enables simultaneous read-out of CRISPR sgRNA sequences alongside droplet-based single-cell chromatin accessibility profiles! Great collaboration with @JeffreyGranja, @WJGreenleaf, and @10xGenomics!

[Ryan Corces @ryancorces]

Now online @NatureGenet! Our efforts to pinpoint functional noncoding SNPs in AD and PD using scATAC-seq, HiChIP, and an integrative machine learning paradigm. Great collaborative work w/ @anshulkundaje @sbmontgom @WJGreenleaf @HowardYChang and Tom Montine https://t.co/FCRKf5uq9U

[Ioannis Karakikes @IKarakikes]

Excited to share our new study published online @PLOSGenetics #PLOSGenetics: A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. https://t.co/tHzP9wvyjV
@bengurionu @StanfordCVI @StanfordCTSurg @yzhang7517 @IsaacPerea

[Aaron Ring @aaronmring]

Is there a bigger scam than the requirement that labs have pay the university "tuition" for graduate students that are working full time in the lab (e.g., year 3 and up)? Why do the NIH and other funding agencies allow this? A pointless drain on research $$$ that makes no sense.