Foo Lab

Heart failure Epigenomics and Molecular Epigenetics Laboratory //
Genome Institute of Singapore @astar_research,
Cardiovascular Research Institute @NUSingapore

[Junedh M. Amrute @junedh_amrute]

In @ScienceMagazine we used single cell multiomics, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated vascular cells in coronary artery disease. We used anti FAP BiTE therapy to reduce plaque burden in vivo.

https://t.co/9bhuNG9Cha

[Roger Foo @rsyf2]

Another year, another retreat for the Foo lab, this time in the shabby chic Lotus Resort at Desaru, Johor Malaysia. Getting to know you, learning science from each other, scientific mentorship and leadership practice. @NUSMedicine @TheFooLab

[Hesham Sadek @heshamasadek]

Plz repost!
New Postdoc Position: Join our lab at UA Sarver Heart Center to develop nanoparticle & protein delivery platforms for cardiac regeneration. PhD in nanotech/biomed eng/pharm sci required; in vivo delivery a plus. Email: [email protected] #Postdoc #Nanomedicine #Regeneration

[Junedh M. Amrute @junedh_amrute]

We discover RUNX1 as a nodal regulator of human cardiac recovery and uncover a druggable epigenetic mechanism in macrophages that orchestrates functional, structural, and molecular features of organ recovery @LavineLab @m_alexanian @Amgen @ImmunoFibHF
https://t.co/0L1GalhOKv

[Roger Foo @rsyf2]

Our Spatial Transcriptomics study of human #aortic full thickness punches shows smooth muscle cell clusters in early atherosclerotic #plaque, and an iron-driven macrophage-like cell state that can be targeted to prevent progression @10xGenomics @TheFooLab
https://t.co/bYvw5RI8XB

[Circulation Research @CircRes]

@CircRes Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium
CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos https://t.co/IoHHcQscCw
by @rsyf2 @josephahill @FaiezZANNAD @ShahzebKhanMD @JenHoCardiology @leahkosyakovsky et al

[Roger Foo @rsyf2]

Organs don't work in silos !! It's time to track outcomes across the disease specialities, when they are so much metabolism driven today @NUSMedicine https://t.co/f1RPY0r4mK

[Junedh M. Amrute @junedh_amrute]

We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in human coronary artery disease and show that treatment with an anti FAP bi-specific T cell engager reduces plaque burden in vivo https://t.co/KnH9PveM5S

[Hesham Sadek @heshamasadek]

Open faculty positions announcement: 2 advanced HF faculty positions are available at The University of Arizona. All faculty ranks. Competitive salaries and startups. Message me for more details. Plz repost.

[Roger Foo @rsyf2]

None of this team entered science to make a high salary. Several could well have a luxury life doing something else. So each time we get a chance to let the hair down and put fun into our science and team building, we make the best of it. A lab retreat to remember @TheFooLab

[Roger Foo @rsyf2]

The wonderful joys of hanging out with younger people...and learning from them about their aspirations and big dreams @TheFooLab going into the new year (early) @NUSMedicine @CvdNus

[Roger Foo @rsyf2]

Grateful for the plug for RESET. We are still on a drive to enrol participants..... free scans and tests, and a 5yr long follow up with the medical team... on a look out for causes and drivers of early heart and metabolic disease @CvdNus @TheFooLab https://t.co/vCxHQujaZq

[Circulation @CircAHA]

#ICYMI: Asns marks cardiomyocyte dedifferentiation @yike_zhu @TheFooLab @NUSingapore @NUSMedicine @chesterleedrum @zentiang @meekelee @Circulation @rsyf2 #AHAJournals

[Foo Lab @TheFooLab]

Early access link below ! :
https://t.co/B4eIM8LXpz

[Roger Foo @rsyf2]

We've found that the cell adherens junction is crucial for cardiomyocyte development through the NF2-YAP-AMOT protein complex @NUSMedicine @NUSResearch @CvdNus @TheFooLab @Meekelee

[Roger Foo @rsyf2]

We've found that the cell adherens junction is crucial for cardiomyocyte development through the NF2-YAP-AMOT protein complex @NUSMedicine @NUSResearch @CvdNus @TheFooLab @Meekelee

[Foo Lab @TheFooLab]

So much good science and fun with old and new friends at #KSCardioEpi24 Hannover Harrenhausen palace. Till we meet again !

#Cardiovascular #Epigenetics #GeneRegulation

[Foo Lab @TheFooLab]

Explore emerging #Cardiomyopathy #Transcriptomics #cardiomyocytes research with field leaders @KeystoneSymp Cardiovascular Epigenetics and Gene Regulation, this April in Hannover! https://t.co/tZ1L1NDPMB #KSCardioEpi24

Catch the discounted reg rates before valentines day !

[Foo Lab @TheFooLab]

Our first manuscript in 2024 published on @eLife Human genomic safe harbours, transgene shutdowns no more !

https://t.co/BQc5Cf9FCr

[M Autio @MatiasIAutio]

Happy to share that our (@TheFooLab @astar_gis @CvdNus) manuscript on human genomic safe harbours validated in hES and differentiated cells is now published in @eLife https://t.co/ZVI0VJzCmv

1/n

[Foo Lab @TheFooLab]

Cardiovascular teams at #nus #cvmdtrp gathering marking the end of the year !

[Roger Foo @rsyf2]

Fun moments this afternoon as the Cardiovascular Programme got together ahead of Christmas... Lucky draw, cash vouchers, ice cream cart, popcorn, photo booth, Santa dressing up... Hilarity all round. Amazing year at @NUSMedicine @NUSResearch @CvdNus

[Foo Lab @TheFooLab]

Year end lab meeting !

Featuring:
Santa claus and the red nose reindeer ?