insideoutbio

Novel Therapeutics acting INSIDE Cancer Cells to take them OUT!

[insideoutbio @insideoutbio]

By switching conformation from the two-stranded right-handed Watson and Crick DNA to a four stranded quadruplex structure, many aspects of gene transcription and RNA processing are modulated. https://t.co/xeuWfuKEp3
#Gquadrupex #flipon #RNA #ZDNA

[insideoutbio @insideoutbio]

The "Flipon" book on Z-DNA and Z-RNA and soft-wired genomes is now available on Kindle for free at Amazon. The book is quite eclectic with the history of DNA and many other exciting discoveries described along with the politcs involved.

[insideoutbio @insideoutbio]

Why Z-DNA is important in human health. A new paper looking at the role of Z-DNA in bacterial biofilms in systemic lupus erythematosus (SLE) with David Pisetsky @Duke

https://t.co/3BFIpgHzxW

[insideoutbio @insideoutbio]

A picture from the Flipon book on the history of Z-DNA and soft-wired genomes showing the author on the right with Francis Crick on the left and Alex Rich in the middle (taken by Shuguang Zhang). Book now has >5000 downloads https://t.co/CvWRjw1IwK

[Research Features @ResearchFeature]

In his new book, Dr Alan Herbert, Founder of @insideoutbio, gives an honest account of his journey in the #discovery of left-handed #DNA.

DOI: https://t.co/gnT62x0CI6

Read our article: https://t.co/w3HaNhgmKT

[insideoutbio @insideoutbio]

Article featuring #flipons, the biology of Z-DNA and Z-RNA and how #science gets done by the curious and the collaborative #genetics #DNA #RNA
https://t.co/XdfOul7Mkh

[insideoutbio @insideoutbio]

@royalsociety Yes, Parinaz Mehdipour at Oxford has just agreed to be the UK based co-organizer. We will discuss the application tomorrow and plan to submit by April 10th. Thanks for reaching out - we are excited about the roles alternative DNA/RNA conformations play in health and disease.

[insideoutbio @insideoutbio]

The hard copy of the flipon book is also available at https://t.co/CvWRjw1IwK (you can use the discount code SMA22)

[insideoutbio @insideoutbio]

The open access version of Alan Herbert's book on flipons is now available for download. Learn about dynamic ways of encoding genetic information within the genome and how these findings pave the way for a new generation of RNA therapeutics
https://t.co/gss7vKviEq

[insideoutbio @insideoutbio]

@CrumlyChuck Thanks Chuck - nice to have the work of so many recognized!

[insideoutbio @insideoutbio]

Altimetric on the Z-DNABERT paper that maps Z-DNA in the human genome to quantitative traits and mendelian disease
https://t.co/nMJ0rlZUPG

[insideoutbio @insideoutbio]

Our paper using the same transformer algorithm in ChatBox (and originally developed at Google) to map Z-DNA in the human genome is now out. We show how variants map to a range of different human traits as well as to mendelian diseases. 10.26508/lsa.202301962 @LSAjournal

[insideoutbio @insideoutbio]

An RNA Microcode Underlying Embryonic Development The microcode embedded in small RNAs bootstraps gene expression at early stages of embryonic development by changing DNA conformation of flipons (Z-DNA, G4 Quadruplexes and other non-B-DNA structures)
https://t.co/3U7OsxtWz1

[insideoutbio @insideoutbio]

An RNA Microcode Underlying Embryonic Development The microcode embedded in small RNAs bootstraps gene expression at early stages of embryonic development by changing DNA conformation of flipons (Z_DNA, G4 Quadruplexes and other non-B-DNA structures)
https://t.co/lRWch6ukZL

[insideoutbio @insideoutbio]

Nucleosomes as mechanical springs that power flipon transitions to change the readout of genetic information by altering the cellular machines assembled at that locus.
https://t.co/ug30FcVRXf

[insideoutbio @insideoutbio]

Great article om Z-DNA and Z-RNA in GEN by Anjali Sarkar

https://t.co/WXtWTs7Uec

[insideoutbio @insideoutbio]

Z-DNA enhances immunotherapy in pre-clinical models of treatment resistant cancers
https://t.co/Rag9YJZD4q

[insideoutbio @insideoutbio]

Z-DNA enhances immunotherapy in pre-clinical models of treatment resistant cancers
10.1038/s41586-022-04753-7

[insideoutbio @insideoutbio]

All things Z-RNA and Z-DNA at the ABZ meeting. Program and registration at https://t.co/j1wy7A8uCC May 25th, 4 hours, virtual, free. Many presentations are just about to be published in peer-reviewed Journals

[insideoutbio @insideoutbio]

Epstein–Barr Virus: Silencing the Enemy within - Z-DNA/Z-RNA flipons and mechanisms to suppress EBV-dependent cancers and autoimmunity https://t.co/3OExQmhQli