InterlineTX

Interline Therapeutics is elucidating molecular mechanisms of disease by correlating human genetics with protein community dynamics.

[Thomä Lab @LabThoma]

An excellent perspective on the personalities of #molecularglues, thanks for covering our work @Dereklowe!

[MVermeulenLab @LabVermeulen]

Check out our high-throughput compatible Thermal Proteome Profiling method called STPP-UP that can be used to profile the cellular targets for drug compounds in an unbiased, proteome-wide manner. Great work from Dick Zijlmans and Miguel Hernandez-Quiles
https://t.co/8JbyMlHEd7

[Ivy Zhang @ivyzhang__]

Interested in predicting mutational impact on protein:protein binding?

Our new preprint provides a workflow (using open-source software, Perses) for running free energy calculations on protein:protein complexes, focusing on diagnosis of sampling issues: https://t.co/Ww7W7cJY5l

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

How AlphaFold2.3 gave us an answer that 2.2 did not: Tetramer of human Protein Phosphatase 2A (light orange)+scaffold subunit (green)+substrate-determining subunit B55alpha (steel)+FAM122A (orange)- a substrate-like inhibitor. Fun collab with @GranaX_Lab https://t.co/5XCZaRbWZa

[Pedro Beltrao @pedrobeltrao]

Now in peer-reviewed form - our study on network propagation of GWAS linked genes across >1000 human traits identifies aspects of cell biology that impact on multiple traits @ibarrioh et al. an @OpenTargets project https://t.co/7yjw8omzi7

[Louis-Jeantet Foundation / Fondation Louis-Jeantet @LouisJeantetFDN]

📢 The Louis-Jeantet Foundation is happy to announce the 2023 #LouisJeantetPrizes, awarded to DARIO ALESSI @mrcppu and jointly to IVAN ĐIKIĆ @iDikic2 @goetheuni @IBC2_GU and BRENDA SCHULMAN @MPI_Biochem
CONGRATULATIONS!
👉 https://t.co/TysOQeQyP8
👇 follow thread

[Mohammed AlQuraishi @MoAlQuraishi]

The final version of our RGN2 manuscript for single-sequence structure prediction is out in @NatureBiotech! Peer review dramatically improved this work, thanks to @fraser_lab, @thisismadani, and anonymous reviewers. For more on what’s new, see thread below by @NazimBouatta ⬇️

[BIOS @bios_community]

Builders 🧱 w/ Zach Sweeney - Co-Founder & CEO @ Interline Therapeutics

Thanks @ZacharyKSweeney for sharing your story building @InterlineTx!

See our episode below...

https://t.co/AuIIECo226

[Chris Ghadban @ceghadban]

Builders 🧱 w/ Zach Sweeney - Co-Founder & CEO @ Interline Therapeutics

Thanks @ZacharyKSweeney for sharing your story building @InterlineTx!

See our episode below...

https://t.co/NmnpdUIsZk

[BIOS @bios_community]

Grand Challenges Facing Life Sciences ���

Hear from Vik Bajaj (@vik_bajaj) - Managing Director @ @ForesiteCapital

Shoutout @ForesiteLabs companies @_Alumis, @InterlineTx, @SestinaB, @tensixteenbio, among others!

Watch BIOS Highlights to learn more...

https://t.co/MjAuUGTqD0

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

#CryoEM structure of CUL7 reveals how it teams up with CUL1 to form an active #ubiquitin E3 ligase.
Check out the latest paper @NatureSMB from Schulman lab @MPI_Biochem.

@LinusHopf
@KheewoongBaek

➡️https://t.co/yGNQ2G7WQL

[Dana-Farber @DanaFarber]

Analysis of tumor samples from Latin American patients suggests correlation between ancestry and specific mutations in lung cancer.

Findings shed light on the evolution of the disease and spur further research for disease prevention and early detection.

https://t.co/HW4xYp720D

[Ed Huttlin @EdHuttlin]

Check out the talk, then try these tools yourself! BioPlexR: https://t.co/Msh0vKfrfL BioPlexPy: https://t.co/8NjqAINF4O

[Ed Huttlin @EdHuttlin]

If you’re at #bioc2022, don’t miss today’s talk at 9 AM PDT/12 PM EDT by Ludwig Geistlinger:
BioPlexR and BioPlexPy: Integrated Data Products for Analysis of Human Protein-Protein Interactions

[David Nusinow @dnusinow]

We're hiring! If you're a computational biologist who is excited about the opportunity to help develop medicines working at the intersection of cancer biology, proteomics, and computation I'd love to talk to you about this job opportunity!
https://t.co/QVWTpDB3li

[Emma Lundberg @Prof_Lundberg]

Help us hack the human body! 😉
Join the @proteinatlas and @_hubmap competition at @kaggle and develop #MachineLearning models for segmentation of functional tissue units from microscope images. https://t.co/pZT7SgYY7S

[Foresite Labs @ForesiteLabs]

Today, we’re highlighting one of our incubated companies: @InterlineTx! Interline Therapeutics is developing novel drugs that target key drivers of inflammation and cancer.

Follow Interline and learn more about the great work they’re doing 👇https://t.co/cF3UhoyLIs

[Nazim Bouatta @NazimBouatta]

We have completed training OpenFold: our PyTorch implementation of AlphaFold2. We are sharing the model weights, training code, and colab notebook. What we have learned should help explore variants of OpenFold. More to come!

[Geoff Macintyre @gjmacintyre]

Chromosomal INstability causes chaotic cancer genomes. Making sense of this chaos was hard. Come sit around the fire and listen to our tale of The #17DeadlyCINs a gripping epic of mechanisms of CIN, therapy response prediction and drug target discovery
https://t.co/mXAeYNNZVg 1/

[Nate Bennett @naterbennett0]

1/7 Improving de novo Protein Binder Design with Deep Learning (https://t.co/M3JITN1nOZ) We show that AF2 is an effective predictor of whether a de novo designed miniprotein will bind to the intended target or not.