Dylan Marchione

here to learn/talk about drug discovery & translational research, with a big emphasis on proteomics

[Dylan Marchione @isocraticflow]

@Sonia_Lombroso @kczar432 @WimmerLab @PierceNeuro @UPenn_SongMing @AllisonMBond @GarciaLabMS Huge huge congrats. This is really a tour de force in linking epigenetics to transcription and splicing all the way to behavioral phenotype. Just 🤯!

[Dylan Marchione @isocraticflow]

@dina_sch @QuastJP This looks awesome, can’t wait to try it. Congrats!

[Dylan Marchione @isocraticflow]

@ProteomicsNews Wow, I heard the PS5 was big but this is outrageous

[Dylan Marchione @isocraticflow]

@izmapf @pennbioeng @PennMedicine Oh man, I remember you presenting this idea in ~2015?! And when so many of us were bouncing around from project to project just trying to make something (anything?) work, you stuck with this and just kept making it better and better. Huge congratulations!

[Agios @AgiosPharma]

#DYK: 70-80% of patients with low-grade #glioma have an IDH mutation. Find out more about our ongoing #personalizedoncology clinical research in IDH-mutant glioma. #BTAM2020 https://t.co/XXz1e0YzeI

[Dylan Marchione @isocraticflow]

@SimoneSidoli @GarciaLabMS @pennbgs @PennEpiInst Thanks Simone, you were an amazing mentor!

[Dylan Marchione @isocraticflow]

@Ryan_Cupo Thanks a lot man. You're next!

[Dylan Marchione @isocraticflow]

@GarciaLabMS @pennbgs @PennEpiInst Woo! Thank you for all the support! Hard to believe I'm not in the lab anymore. And man, that picture just keeps popping up. I thought what happened at the retreat stayed at the retreat! 😑😬😅

[Dylan Marchione @isocraticflow]

@JohnRYatesIII Loved this book. Another example is "The Man who Loved Only Numbers," a biography of Paul Erdös. He would come across an interesting paper and just show up at the author's door a few days later, and basically live with them until he lost interest or they kicked him out

[Isabell Bludau @BludauIsabell]

Happy to share this #review @NatRevMCB I wrote together with Ruedi Aebersold. It discusses functional diversification along the axis of gene expression with a specific focus on #massspectrometry based #proteomics and #interactomics. @ETH @MPI_biochem
https://t.co/VG90gVGMgS

[Dylan Marchione @isocraticflow]

@pjobphd Nice, now you can also block some membranes while you're having breakfast. That's being resourceful

[Dylan Marchione @isocraticflow]

@Y_Gilad Did you notice any batch effects between the first and second 500?

[Dylan Marchione @isocraticflow]

@pjobphd Where in Boston is this healthy collaborator?! In Cambridge we've been operating at half capacity since mid-Jan

[MetaMorpheus @metamorpheus.bsky.social @Smith_Chem_Wisc]

As one of the new generation of proteomics innovators, everyone should be paying attention to your work!!!

[Covaris @Covaris]

Recent paper, HYPERsol: High-Quality Data from Archival FFPE Tissue for Clinical Proteomics (Marchione et al.) highlights an optimized protein extraction protocol from FFPE developed using Covaris AFA in combination with ProtiFi S-Trap https://t.co/mDt4nA8TF8 #clinicalproteomics

[Hannah Uckelmann @HannahUckelmann]

Excited to share our work on how Menin-MLL inhibition can reverse self-renewal induced by NPM1c mutations at different stages of leukemia development. https://t.co/sEgUArUUXH

[Chris Cornthwaite @cjcornthwaite]

In my Twitter poll from this week, 70% of those #withaphd working outside of academia said they don't regret leaving.

And I don't either.

You have no idea the impact PhDs are having. The cool stuff they get to do. The world-changing they're doing.

@AcademicChatter #phdchat

[David Nusinow @dnusinow]

I’m thrilled to announce the publication of the quantitive proteomic profiling of the Cancer Cell Line Encyclopedia. The @GygiLab in collaboration with colleagues at Novartis and the Broad we measured the proteomes of 375 cell lines from various tumor lineages (1/13)

[Ryan Cupo @Ryan_Cupo]

Very excited to share some of my PhD work in the @ShorterLab

Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

https://t.co/f6X5EpvGNs @biorxiv

1/n

[Dylan Marchione @isocraticflow]

@baezaj83 Thanks for all of your help along the way!