J.Agustin_Cruz

Immunologist with interest in systems biology, signaling pathways, and disease resolution #Scientistlife #Immunology #Systemsbiology - Views are my own.

[J.Agustin_Cruz @JACruz5]

Happy to share my #postdoc work at the Leelab in @compbiopitt. We used #CRISPR , #QuantitativeImaging,& #SystemsModeling to study #singlecell #signaling.🙏re-tweet🌎.#cells @VUCellImaging @QIatCSHL @ahoffmann2716 @roy_wollman @UriAlonWeizmann,@DoctorF @Suzzanne_Gaudet,@carvunis

[bioRxiv SysBio @biorxiv_sysbio]

A stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB https://t.co/3kh3n0bfWt #biorxiv_sysbio

[J.Agustin_Cruz @JACruz5]

@ucsf_library are #libraries open to non-university people yet? Thank you

[J.Agustin_Cruz @JACruz5]

@DeltaNewsHub forced me to reschedule from today to tomorrow. I will not get to work as planned, yet the agent could Not provide any sort of compensation. Please, do something to make this right. #flightdelay #dotflight #DOT #whohelpsthelittle #businessAlwaysWin #consumersRights

[J.Agustin_Cruz @JACruz5]

@CarlosMMinutti @Neuro_CF Congrats!!!

[J.Agustin_Cruz @JACruz5]

@CopaAirlines flight cm383 left 3h late last night. My friend is connecting to Santiago de Chile in cm395, and he only has 10 min to switch planes. What are you going to do about that?

[J.Agustin_Cruz @JACruz5]

@DuquesneLight No power in Friendship and the reporting tool online doesn't work. It gives an error. @DuquesneLight any estimate for how long will this take?

[J.Agustin_Cruz @JACruz5]

Look how much I learned on Duolingo in 2022! How did you do? #Duolingo365

[J.Agustin_Cruz @JACruz5]

@ElowitzLab That's brilliant!

[ElowitzLab @ElowitzLab]

In Klumpe et al, we systematically analyzed pairs of BMP signaling to cells w/different BMP receptor combos. Different ligands can act equivalently with respect to one receptor context but quite differently with respect to another... https://t.co/ivrik38ZmE

[J.Agustin_Cruz @JACruz5]

Excited to be in PDX for #AAI2022. Here to learn and socialize with amazing researchers. #immunology2022

[J.Agustin_Cruz @JACruz5]

There’s more to the adaptive immune response than antibodies. Check out this preliminary data on the impact of the Omicron variant on T-cell responses.

[Harlan Robins @HarlanRobins]

Preliminary data using @AdaptiveBiotech's immune medicine platform finds that greater than two thirds of the T-cell response to vaccines is on target against the #Omicron variant. New manuscript available here: https://t.co/95Ff0NB6c7

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[IdoAmitLab @IdoAmitLab]

@nickhaining @ArsenalBio Congratulations Nick and @ArsenalBio, what a great match, expecting exciting developments in CAR-T therapeutics

[Daniel Bryan Goodman @dbgoodman]

Finally, we looked more closely at signaling differences via scRNAseq/CITEseq. CAR-Ts using the BAFF-R signaling domain (from B cells!) were shifted toward a strong cytotoxic signature which has been associated w\ better patient outcomes in TILs and CAR-T infusion products. 7/10

[Nature Medicine @NatureMedicine]

In an interim analysis of a phase 1 trial, repeated intracranial infusions of HER2-specific CAR-T cells were well tolerated with no observed dose-limiting toxicities in 3 young adult patients with #CNStumors @VitanzaNick @seattlechildren @SCTherapeutics
https://t.co/nD7LCOMmRz

[J.Agustin_Cruz @JACruz5]

@helenevaadams Nice catching up at #AAI2021 and keep the good work going!!!

[J.Agustin_Cruz @JACruz5]

@ImmunologyAAI https://t.co/Xo8gZKqBQp Come check it out in the last 5 minutes :-)

[J.Agustin_Cruz @JACruz5]

@helenevaadams https://t.co/Xo8gZKqBQp

[J.Agustin_Cruz @JACruz5]

Stochastic pooling of IKK/NEMO complexes... by Dr. J. Agustin Cruz
AAI VIRTUAL; May 15 2021; 317333
https://t.co/Xo8gZKqBQp Poster#402 @ImmunologyAAI 2021 #Immunology2021

[J.Agustin_Cruz @JACruz5]

@helenevaadams That will definitely make someone's day...if they visit. I suspect that -we- the presenters will be the only "visitors". What poster # are you? #Immunology2021

[Irina Chelysheva, MD, PhD @chelysheva_i]

#Bioinformatics guys, which language do you use for #MachineLearning? Which libraries and why?
I go for #Python and https://t.co/SrdAUofVYH
Any reason for picking #RStats and caret, for example?🧐

[Dr. Irene Salinas Remiro @DrSalinasLab]

@JACruz5 Disgraceful! I am gonna really loose it if I cannot access live talks! @AAI needs to do something! #AAI2021 is not working