Manish Jain

Biochemist, Pharmacologist, Structural biologist
University of North Carolina at Chapel Hill

[BryanRoth @zenbrainest]

DREADDs in humans--update:
3 clinical trials using hM4Di in humans registered in China. 2 for epilepsy and 1 for Parkinson's Disease.
In our original paper we stated:
"...We suggest that at least one of these designer receptors, hM4D, will prove useful for neuronal silencing in vitro and in vivo.."
It seems we were correct.

[BryanRoth @zenbrainest]

I'm giving a talk @UCSF Thursday
Mostly unpublished and, I believe, tres cool

[BryanRoth @zenbrainest]

UNC Scientists Reveal Molecular Details That Make Coffee Taste Bitter | Newswise https://t.co/V50G8XygyJ

[Yoojoong Kim @KYoojoong]

Huge thanks to my mentor @zenbrainest for this work and for guiding me in structural biology and pharmacology. Many thanks also to @rgumpper, Yuxuan Zhuang, and Ron Dror for the MD simulations!

[BryanRoth @zenbrainest]

I'm giving a talk on 'Molecular Glues and GPCRs'
Dr. GPCR University with Dr. Bryan Roth
Thursday, April 9 · 10:00 – 11:35 AM (America/New_York)
https://t.co/Set0Unik1Y

[nick_rite @nick_rite]

It's out - we isolated mGluR2 containing assemblies from brains and resolved various conformational and compositional states. A subtype-specific functional property shapes the conformational landscape. Project like this has been a dream of mine since I started my science journey

[Manish Jain @jainmk6]

@Amren_Ajay Congratulations!!

[Robin Carhart-Harris @RCarhartHarris]

Psychedelic visions are fluid ever changing Maya

[BryanRoth @zenbrainest]

This is my drug!!!

[BryanRoth @zenbrainest]

A fun interview about the polypharmacology of #psychedelics
https://t.co/0fXWYjt2RN

[BryanRoth @zenbrainest]

Huge implications for #GPCR-based drug and sensor design
Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors | https://t.co/w9wLk96htr

[BryanRoth @zenbrainest]

The polypharmacological profiles of xanomeline and N-desmethylxanomeline | bioRxivx. Latest from ⁦@RothLabUNC⁩ https://t.co/zBex1Q9AO9

[BryanRoth @zenbrainest]

LSD is an amazing molecule!
https://t.co/neMkbCqWGd

[Aya Osman, PhD @AyaOsman]

Official announcement: this September 1, the Osman laboratory will be opening its doors in the biological sciences department at SUNY, Albany!

Anyone interested in joining the lab, please contact me.

[email protected]

Lab website coming soon!

@ualbany

[Manish Jain @jainmk6]

Thanks, Fred, for featuring our recent Neuron article in Migraine Science Collaborative!!

Psychedelics to Treat Human Disease: Many Targets, Lots of Complexity https://t.co/6vK9d1Tc93

[Manish Jain @jainmk6]

Beautifully covered story of my latest published paper on Psychedelics in Neuron! https://t.co/ukLlTC6eh2

[BryanRoth @zenbrainest]

More Than Serotonin: How Psychedelics Engage the Whole Brain
#psychedelics
https://t.co/LfepD1ksHQ

[Manish Jain @jainmk6]

More Than Serotonin: How Psychedelics Engage the Whole Brain - Neuroscience News https://t.co/NSpxIt8uc5

[John Fryer, PhD @johnthefryer]

Hugely important work from ⁦@zenbrainest⁩ that opens new doors (and immensely complicates the picture!) The polypharmacology of psychedelics reveals multiple targets for potential therapeutics: Neuron https://t.co/OvrSOjuir3

[Ryan Gumpper @rgumpper]

It's finally out! Our "somewhat" thorough study on psychedelic polypharmacology. Congrats to @jainmk6 @zenbrainest and everyone else involved! https://t.co/9dIzRXs2ry
#psychedelics