Jakob Höppner

M.D. | Research-Fellow @MGHBoneResearch @Harvardmed | Working on PTH1R signaling

[NatureStructMolBiol @NatureSMB]

New online! How ligands tune the parathyroid hormone receptor’s grip on β-arrestin https://t.co/me2693i136

[ASBMR @ASBMR]

🎉 Announcing the 2026 ASBMR John Haddad Young Investigator Award recipients!

See you in Snowmass, CO for the AIMM‑ASBMR Young Investigators’ Meeting! https://t.co/ScBeHwxDzy

[FASEB @FASEBorg]

View the newest findings online on G-protein coupled receptor kinases and arrestins from this year's conference. If you weren't able to join us in Niagara, this will still keep you up to date—anywhere, anytime: https://t.co/JMmu1cOOE6

[nature @Nature]

Researchers have mapped the key structural changes in the pelvis that enabled early humans to first walk on two legs and accommodate giving birth to a big-brained baby

https://t.co/MO82BoXy2u

[Nature Portfolio @NaturePortfolio]

The upper part of the human pelvis, known as the ilium, underwent two major structural innovations during evolution that enabled humans to walk on two legs, according to a paper in @Nature. https://t.co/qHoOH8xuJQ

[Frontiers - Endocrinology @FrontEndocrinol]

New Research: Human diseases caused by homozygous PTH1R mutations https://t.co/cvKaouWmFq #FrontiersIn #Endocrinology

[Jakob Höppner @jakobhoeppner]

We find that PTH1R/Gas/PKA/SIK3/HDAC4 activation drives the growth plate phenotype and show that an inverse agonist can correct lab abnormalities @lab_wein @CSR_MGH @MGHBoneResearch @MGBResearchNews @P_Brugarolas @bondamidebond @NeenaNizar

[Jakob Höppner @jakobhoeppner]

Check out our new paper describing a novel mouse model of Janssen’s Metaphyseal Chondrodysplasia out in @PNASNews: https://t.co/RzXUpBPK2W

[Jakob Höppner @jakobhoeppner]

Both strategies profoundly enhance the efficacy of PTH peptides in vitro and in mice. Check out the results here: https://t.co/oBITC9vKYn
@GardellaPhd @MMichael @bondamidebond @MaryBouxsein @CSR_MGH @MGBResearchNews

[Jakob Höppner @jakobhoeppner]

I’m thrilled to share our recent publication on PTH-peptide lipidation out in @NatureComms.
We investigate two distinct PTH-peptide lipidation strategies: 1) to promote binding to serum albumin and 2) a lipid chain designed for in situ anchoring of the ligand to the receptor.

[ASBMR @ASBMR]

The President & Founder of the Jansens Foundation, Neena Nizar, Ed.D. will be moderating a webinar on the molecular mechanisms of Jansen's Metaphyseal Chondrodysplasia (JMC) with Jakob Hoeppner, M.D. Register today for the webinar on Tuesday, June 10.
https://t.co/0O5UBZqGLh

[NEJM @NEJM]

Case Records of the Massachusetts General Hospital (@MassGeneralNews): A 72-Year-Old Woman with Altered Mental Status and Acidemia https://t.co/SDPeO9SjOI

#MedTwitter

[Endocrine Society @TheEndoSociety]

Join the Bone & Mineral SIG for the upcoming webinar, PTH/PTHrP Receptor Signaling and Rare Diseases, on Tuesday, December 3, at 11:30 AM ET. Our faculty will discuss FD/MAS and emerging treatments, including results of clinical trials: https://t.co/EoyfINxBBw @jakobhoeppner

[The Journal of Bone and Mineral Research @The_JBMR]

Researchers in this #JBMR article report two new cases of Eiken syndrome, an extremely #rare genetic disorder of skeletal development, sharing the exact same change in the PTH1R gene @jakobhoeppner @moiracheung @moiracheung @OUPMedicine

Read more here: https://t.co/hxsO50upeA

[Neena Nizar @NeenaNizar]

Amazing rare bone meeting @ASBMR with Smitha Jha @NIDDKgov n Jakob Hoppener @MGHBoneResearch
#PatientAdvocacy #RareBone

[ASBMR @ASBMR]

The day before the Annual Meeting, we will gather foremost experts to foster the exchange and probing of data and insights to advance and boost basic, translational and clinical research in rare bone diseases. Be there: https://t.co/eazRpN04Gy

[Endocrine Society @TheEndoSociety]

2024 Outstanding Abstract Award Winners | Our recipients will receive complimentary travel to #ENDO2024. View the list of winners (https://t.co/rWpwIwH0am). There is still time for you to submit your late-breaking abstract before this Wednesday, April 10: https://t.co/9iluYKHAvm

[Center for Musculoskeletal Research @CSR_MGH]

Another fantastic presentation by Jakob Hoeppner from MGH: “Unravelling the Pathophysiology of Eiken Syndrome: Deciphering the Role of the PTH
Receptor's C-Tail in Enchondral Ossification and Bone Mineral Homeostasis” @NIH_NIAMS

[Top Science @isciverse]

Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants

@J_A_C_S #Chemistry #Science #Chemed

https://t.co/s7tAfbw1ye

[Frontiers - Endocrinology @FrontEndocrinol]

New Research: Cardiorespiratory fitness in adolescents and young adults with Klinefelter syndrome – a pilot study: Background

Klinefelter syndrome (KS) may be associated with a wide spectrum of phenotypic changes including… https://t.co/9svubXwjpO #Endocrinology #Endo