James A. Oo

Postdoctoral researcher | @BrandesLab | Long non-coding RNAs, epigenetics and chromatin in the cardiovascular system @UofGlasgow alumnus 🏴󠁧󠁢󠁳󠁣󠁴󠁿

[James A. Oo @JamesAOo7]

#ChromatinBiology #SWISNF #lncRNA #Epigenetics #NatureComms #Enhancers #ChromatinRemodeling
#AcademicTwitter

[James A. Oo @JamesAOo7]

New year, new paper 🚨

How does a chromatin remodeling complex, conserved across species and expressed in all cells, find cell type-specific enhancers?

Read our @NatureComms paper to see how #lncRNAs play a fundamental role:

🔗 https://t.co/g4eCUbci7b

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[James A. Oo @JamesAOo7]

This work was made possible with support from @GoetheUni, @CPI_Cluster, @dfg_public, and @DZHK_de.

Special thanks to co-authors: @tim_warwick @Kat_Pimpi @CristianPG_mlg @KurianLab @Ralf_Gilsbach @TheMarcelSchulz @iDikic2 @Ralf_P_Brandes and everyone else involved!

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[James A. Oo @JamesAOo7]

Honoured to have been a part of this huge effort and to have developed such strong scientific collaborations along the way 🙌🏻. Congratulations @CristianPG_mlg, @iDikic2 and everyone else involved 🎉🎊

[Cristian Prieto-Garcia @CristianPG_mlg]

It is finally out! My first @ScienceMagazine paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor @iDikic2 for all the support and trust ! 🫶. Science https://t.co/P7xasHgVGw

[Cell @CellCellPress]

Now online! Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells https://t.co/OKr0uUEz1r

[Tim Warwick @tim_warwick]

Do you want to detect #RNA-#DNA interactions from RADICL-seq, Red-C or GRID-seq, but lack a reliable method? Then try RADIAnT, our new statistical framework for calling robust, consistent interactions from RNA-DNA ligation methods https://t.co/3BEH8XmUvZ

[Molecular Cell @MolecularCell]

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle https://t.co/qWqQPVNslR

[James A. Oo @JamesAOo7]

@FabianHahner3 @CPI_ExStra @BrandesLab Still a long long way to go for publication!

[James A. Oo @JamesAOo7]

@tim_warwick @Kat_Pimpi @CristianPG_mlg @KurianLab @Ralf_Gilsbach @TheMarcelSchulz @iDikic2 @mixmue @Ralf_P_Brandes Thanks to @CPI_ExStra @trr267 @goetheuni @dfg_public @dzhk_germany and @BrandesLab for supporting the project!

[James A. Oo @JamesAOo7]

Happy to share our pre-print on #lncRNA recruitment of SWI/SNF to cell type-specific #enhancers.

We performed several sequencing experiments to reveal the mechanism for how the highly conserved and ubiquitously expressed SWI/SNF finds its DNA targets genome-wide.

[bioRxiv @biorxivpreprint]

Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers https://t.co/S9FQNZ3PyF #bioRxiv

[James A. Oo @JamesAOo7]

Thanks to those involved so far @tim_warwick @Kat_Pimpi @CristianPG_mlg @KurianLab @Ralf_Gilsbach @TheMarcelSchulz @iDikic2 @mixmue @Ralf_P_Brandes

[Nature Methods @naturemethods]

A method for genome scale lncRNA screening using CasRx was developed by Ronald Rad, Juan Montero and colleagues @DKFZ, @TU_Muenchen.

https://t.co/sbQLGXHkVX

[Kurian Lab @KurianLab]

Are you a developmental biologist studying cardiac cell fate decisions with an interest in RNA biology looking for a post-doc position?

Join us at our new lab at Goethe University Frankfurt
@UK_Frankfurt

@ERC_Research

Please RT🙏

[James A. Oo @JamesAOo7]

Thanks again to all involved. @BrandesLab @Ralf_P_Brandes @iDikic2 @CiesekSandra

[James A. Oo @JamesAOo7]

Absolutely thrilled to have received the 2022 Rudi Busse award from the medical faculty of @goetheuni for my #PhD thesis on #lncRNA maintenance of #gene expression and #genome stability. Very nice ceremony tonight at the Dies Academicus in Frankfurt.