Jim Berstler

Proud dad with an assortment of interests including science, history, percussion, and Wendy's.

[Xavier Lab @TheXavierLab]

New work, now online in @CellCellPress! Using a phased, binder-first strategy, we identified a ligandable pocket on CARD9 and discovered a small-molecule inhibitor of CARD9 inflammatory signaling. (1/7)
https://t.co/Iol4elpGSR

[Dr. Marty Makary @DrMakaryFDA]

The new Plausible Mechanism Pathway will bring the power of personalized therapies — like we saw with Baby KJ — to more patients with rare diseases. Our piece in this week’s New England Journal of Medicine:
https://t.co/1BMeLSfyAl

[Jim Berstler @jberstler]

A year of remarkable achievements and progress in child health!

[CHOP Research @CHOP_Research]

As #2024 comes to a close, our Research Annual Report is a celebration of the life-changing solutions we've created to give every child the best opportunity for a bright future. View the report online now. https://t.co/smYXohymzi

#YearInReview #ChildrensHealth #CHOPResearch

[Jim Berstler @jberstler]

A new frosty flavor joins the family! Coming Nov 12th

https://t.co/bkpCQw3vTs

[Jim Berstler @jberstler]

Love this team!! #LGM

[New York Mets @Mets]

HOW ‘BOUT THIS TEAM??? #MetsWin #LGM

[Jim Berstler @jberstler]

LGM!! What a game

[New York Mets @Mets]

GOT MORE IN US. #MetsWin #LGM

[Jim Berstler @jberstler]

Sharing this recent publication on identifying therapeutic vulnerabilities of aneuploid cells. I enjoyed developing the small molecule repurposing screen for this project!

https://t.co/dnouvxdxBJ

[CHOP Research @CHOP_Research]

.@childrensphila received a 2024 Fire Award from @phlbizjournal and PHL Inno for advancing #CellAndGeneTherapy innovation forward. Dr. Sue Furth, Peter Grollman, Dr. Johannes van der Loo, & Katherine Helbig represented CHOP at the award ceremony. https://t.co/bEMyu4AzRi

[Jim Berstler @jberstler]

Celebrating five years of the CGTC! So much has been achieved with so much yet to be done for our patients.

#genetherapy #celltherapy #innovation

[CHOP Research @CHOP_Research]

The Cell & Gene Therapy Collaborative at @ChildrensPhila is celebrating 5 years of ingenuity + innovation! Learn how the unique center is making their resources available to as many faculty as possible: https://t.co/5WPMUy0jfe

[Jim Berstler @jberstler]

Great news for DMD patients! Expanded label for Elevidys from Sarepta. #genetherapy

[Sarepta Therapeutics @Sarepta]

BREAKING: Today, we announced the U.S. FDA has expanded the product label for our gene therapy and more people may be able to receive treatment.
Intended for U.S. audiences

[Jim Berstler @jberstler]

Yessss! Thank you, Wendy 🥰

[Wendy’s @Wendys]

WE HAVE SAUCY NUGGS IN OUR APP NOW SEND TWEET

[Jim Berstler @jberstler]

A well written resource on the complex world of RNA....valuable and quite interesting!

[National Human Genome Research Institute @genome_gov]

RNA is…complicated. If it’s not confusing enough that there are many types of RNA, some RNA molecules also fold into different shapes that help their stability and functions. Not to worry! We break it all down for you in our new fact sheet: https://t.co/f0bpvxV1ov

[Jim Berstler @jberstler]

Great overview of the gene therapy story at CHOP. Looking forward to the next 30 years!

[CHOP Research @CHOP_Research]

Decades ago, Dr. Kathy High, with @ChildrensPhila & @PennMedicine colleagues, began an unprecedented journey of basic & clinical research, which paved the way for the @US_FDA approval of a gene therapy to treat #Hemophilia patients. Learn more: https://t.co/h0VZjWZGh6

[Jim Berstler @jberstler]

Come by and talk to us about CHOP Cell and Gene Therapy! #asg

[CHOP Research @CHOP_Research]

Our Clinical Vector Core team says hello from #ASGCT2024! Now until May 11, these @ChildrensPhila cell & gene therapy experts are at Booth #613 to answer your questions about affordable, flexible, & high-quality vector production. Learn more: https://t.co/ZA2iaKRaRs

[ASGCT @ASGCTherapy]

Coming up soon at #ASGCT2024: Hear from Drs. Beverly Davidson (@ChildrensPhila) + Philip Gregory (@Regeneron) during today's George Stamatoyannopoulos Memorial Lecture and from @davidrliu during the Outstanding Achievement Award Presentation! https://t.co/dwsUS1CWm3

[Children's Hospital @ChildrensPhila]

An international consortium led by Dr. Stephan Grupp published final results of a key clinical trial on gene therapy CASGEVY for sickle cell disease treatment. The findings, published in @NEJM, led to FDA approval of CASGEVY™ in December 2023.

More: https://t.co/Yd1HogdVfO.

[Molecular Therapy Family of Journals @MolTherapy]

CAR-T cell manufacturing landscape – lessons from the past decade and considerations for early clinical development https://t.co/BwVS4NHYfR #MTMCD

[Jim Berstler @jberstler]

Sharing this recent paper in Nature Methods which describes the creation of a publicly available cellular imaging dataset known as CPJUMP1.

It was a privilege to be part of this collaborative team while working at the Broad Institute! @DrAnneCarpenter

https://t.co/PVJkkBowrT

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in bispecific antibodies for cancer therapy, this Review in the April issue covers bispecific T-cell and NK-cell engagers, tumour-targeted receptor agonists, checkpoint inhibitors and more https://t.co/pc2gZlszFE https://t.co/qzsydjWLd4 #AACR24