Josh Backman

Statistical Geneticist at Regeneron Genetics Center. Fan of science, my dog, and the Dallas Cowboys. Opinions my own.

[Josh Backman @jdbackman]

We're hiring a Manager, Analytical Genetics to support growing efforts in large-scale proteomics at the RGC. Are you interested in applying machine learning to develop prediction models for age-related diseases? Apply below!

https://t.co/leZgjHLoRb via @regeneron

[Regeneron Genetics Center @RegeneronDNA]

With ~1M exomes sequenced, we published the largest set of human protein-coding variation to date today in @Nature. RGC-ME data contains genetic variation from individuals of African, American, South and East Asian and Middle Eastern ancestry.

[Josh Backman @jdbackman]

We are still looking for a statistical geneticist to help drive our efforts in rare diseases! Reach out or apply at the link below if interested! https://t.co/6xjErdku6H

[Josh Backman @jdbackman]

I'm hiring! Check out our new opportunity to join the analytical genetics team at the RGC below...
https://t.co/uSubUxMWxn

[Josh Backman @jdbackman]

I'm hiring! Check out our new opportunity to join the analytical genetics team at the RGC below...
https://t.co/uSubUxMWxn

[Jonathan Marchini @marchini]

Very excited to share our paper on genetics of the MCPS. Before you dive in a key point to highlight : from 1998-2004 our @UIME_UNAM & @Oxford_NDPH colleagues had the vision to conceive the study, and then visit >100,000 houses in Mexico City to recruit 150,000 participants 🤯

[Josh Backman @jdbackman]

Genotyping, sequencing and analysis of 140,000 adults from the Mexico City Prospective Study https://t.co/EVyOrJr8or

[Regeneron Genetics Center @RegeneronDNA]

Congratulations to our very own, @joellembatchou, Ph.D., Manager of Statistical Genetics, as she was recognized as one of @FierceHealth and @FierceMedTech's rising stars in health tech! Join us in giving her a round of applause 👏 and read more about her inspiring work.

[Josh Backman @jdbackman]

We are still looking for a statistical geneticist to help drive our efforts in rare diseases! Reach out or apply at the link below if interested! https://t.co/6xjErdku6H

[Josh Backman @jdbackman]

Our team is hiring! Are you a statistical geneticist with an interest in rare disease genetics, family-based analyses, and/or working with sequence data from diverse and understudied populations across the globe? Reach out or click below to learn more https://t.co/p8owNZwRtF

[Open Targets @OpenTargets]

First up — we have a new ‘Gene Burden’ datasource

It incorporates the results of the gene burden analyses performed by @RegeneronDNA & @AstraZeneca

Kudos to both teams!
Quanli Wang @RyanDhindsa @kerencarss @SlavePetrovski @jdbackman @jakphd @Mar_ferreira17 @marchini @gabecasis

[Josh Backman @jdbackman]

@Bun_Without_B @Nature Thanks for the read! We did not do a missense only gene burden. That wouldn't be quite right, since there are plenty of genes in (1) that would provide missense only results, if tested. You should be able to generate a version of missense only gene burden tests via the UKB RAP.

[Josh Backman @jdbackman]

Check it out! Our work on the exome sequencing and analysis of 450k UK Biobank participants is now out in @Nature. Huge thank you to everyone who made it happen!

[Regeneron Genetics Center @RegeneronDNA]

Read our paper on the exome sequencing of 454,787 @uk_biobank participants, published in @Nature. Our scientists continue to push the boundaries of genomics. Their work lights up our genome!

[Regeneron Genetics Center @RegeneronDNA]

Our recent genome-wide analysis shows that levels of the ACE2 receptor influence COVID-19 risk. A genetic variant near the ACE2 gene decreases levels of the SARS-CoV-2 gateway receptor by 37% and infection risk by 40%. Read more about our recent discovery in @NatureGenet.

[Josh Backman @jdbackman]

Our team is hiring! Are you a statistical geneticist with an interest in rare disease genetics, family-based analyses, and/or working with sequence data from diverse and understudied populations across the globe? Reach out or click below to learn more https://t.co/p8owNZwRtF

[NHGRI-EBI GWAS Catalog @GWASCatalog]

Regeneron #sumstats now available in the @GWASCatalog, including gene burden tests! Thanks for sharing this valuable dataset @jdbackman @RegeneronDNA @uk_biobank https://t.co/azgupaaz4Q

[Jack Kosmicki @jakphd]

A lovely perspective article out today in @Nature News and Views by @okada_yukinori & @qbw_128 on @jdbackman's (@RegeneronDNA) UKB 450k exome sequencing study.

https://t.co/VxDL8HKS3F

[Josh Backman @jdbackman]

@marcmaxmeister @EricTopol @Nature @gabecasis @uk_biobank We've requested @Nature make it open access. Should be available shortly!

[GenScript @GenScript]

A #LandMark achievement in the history of human #Genetics ! Scientists from @RegeneronDNA have uncovered hundreds of genes that contribute to different traits and diseases👏👏👏!

Thanks to all the authors for lighting up our #genome👍👍👍@jdbackman

[Josh Backman @jdbackman]

@patrickglad @gabecasis @michelnivard @jakphd @RegeneronDNA @Nature @uk_biobank For our study we did not use the self reported ethnicity data . We defined ancestral super group for each sample by projecting onto principal components from hapmap3. Hope that clarifies your question!

[Josh Backman @jdbackman]

@Sumaiyalqbal @jakphd Thanks so much!