Jan-Daniël de Leede

PhD student in the Sonnen lab, @_hubrecht | signalling dynamics in intestinal organoids

[Jan-Daniël de Leede @jddeleede]

Very grateful to have been part of the team trying to figure out the function of the 'cryptic rhythms' we found in the small intestine! It turned out these signalling oscillations encode information for cell fate decision! Check out below how we discovered this! ⬇️

[Ina Sonnen @SonnenKatharina]

🎉 Our paper is out today in @ScienceMagazine!

How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter!

So proud of our three shared first authors, Sonja Weterings, @HiromuneEto & @jddeleede!

🔗 https://t.co/FGTizqkTZk

[Ina Sonnen @SonnenKatharina]

How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signalling oscillations to regulate precision of somite formation and growth. Check the full story: https://t.co/ZBxdOXbXGB

[Jan-Daniël de Leede @jddeleede]

I'm happy to have contributed to this project and great to see the preprint out! Check it out below⤵️

[Ina Sonnen @SonnenKatharina]

Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: https://t.co/qvEsbAbx5O

[Wilke Meijer @wilke_meijer]

I am excited to share that we recently published a review in 'Current Opinion in Systems Biology'. Here we summarize and discuss recent advances in somitogenesis research.

This was very fun to write, thank you @SonnenKatharina for the opportunity!

https://t.co/rlL7hXn75W

[Ina Sonnen @SonnenKatharina]

Hes genes are dynamically expressed in many tissues. But how do dynamics differ between tissues and are they always oscillatory?

We have addressed this question in the context of the developing embryo, where somites and neural tube form side-by-side.

https://t.co/sj3gPFB9Ph

[Ina Sonnen @SonnenKatharina]

It is a pleasure to highlight this paper by @MDiazCuadros and Olivier Pourquié et al., in which they show that mass-specific metabolic differences affect developmental time in mouse and human somitogenesis: https://t.co/g2SK8JqbYC

[Jan-Daniël de Leede @jddeleede]

What a conference! Learned so much, and even met my image analysis hero @haesleinhuepf !! #cbias2022 #imageanalysis

[Jan-Daniël de Leede @jddeleede]

With @HiromuneEto on our way to #CBIAS2022! Looking forward to discussions and learning about new tools! #imageanalysis #singlecelltracking #teamorganoid

[RTV Utrecht @rtvutrecht]

Kom van dat dak af, zong Peter Koelewijn. Maar deze toeschouwers vinden het uitzicht waarschijnlijk te mooi. https://t.co/0TR5eDsuxR #LaVuelta22 #Utrecht

[Jan-Daniël de Leede @jddeleede]

@MariettaZinner Congrats Marietta🥳🥳

[Prisca Liberali @priscaliberali]

I still can’t believe it!! Phenotypic landscape of 400k intestinal organoids. The 3k compound fingerprints allowed us to infer the first map of functional interactions and to translate our findings into intestinal regeneration in vivo
https://t.co/uflBqrBKTd

[Nature Portfolio @NaturePortfolio]

This week on the Nature cover: Gut profiles. Screen of intestinal organoids reveals mechanisms of tissue regeneration. Browse the issue here: https://t.co/UIRElyEkgn

[Koen Oost @KC_Oost]

Design principles of tissue organisation: How single cells coordinate across scales🔭↔️🔬. Nice work @MariettaZinner 👩‍💻Ilya Lukonin 👨‍💻 and @priscaliberali 👩‍💻 ! Want to know and learn more about this topic? ➡️https://t.co/dfs7pNGa0J

https://t.co/cahljDMilD

[Hubrecht Institute @_Hubrecht]

BIG step in cancer research: @_Hubrecht scientists create living biobank for colorectal cancer:http://t.co/WstmvzNfGh

[BBC Radio 1 @BBCR1]

"I have to think of it as the final thing we're doing..." Chris Martin on forthcoming album 'A Head Full Of Dreams' https://t.co/bm2NvbKaEk

[FC Dordrecht @fcdordrechtnl]

Rolin die zich ergerde aan het uitzicht op het pershok en vroeg of hij het dan ieder geval lelijk groen mocht verven.

[Coldplay @coldplay]

Band just finished beautiful new song Miracles for the epic #Unbrokenmovie, directed by Angelina Jolie. PH

[Jan-Daniël de Leede @jddeleede]

@janwillemeshuis gefeliciteerd Willem!

[Jan-Daniël de Leede @jddeleede]

@NepentheZ the best non-rare team in fifa! http://t.co/te5QSQ2OPB

[Coldplay @coldplay]

Stream #GhostStories in full ahead of release - for free - on @iTunesMusic at http://t.co/ybyzyYiyKc NOW! (Just click the Featured Video.) A