@simocristea Interesting points! Me (and others) have tried to tackle this problem (at least partly) by developing classifiers with a "certainty" score and only assign cell types when enough evidence if found (disclaimer: this depends on the used reference) -> https://t.co/VmUUgxyPo2
Check out this spotlight article of @StJudeResearch in @CellPressNews on our previous @CD_AACR paper on the elevated mutational age in blood of childhood cancer survivors!
The latest paper from the @BoxtelLab is out in @CD_AACR. It was great to collaborate with @ElineBertrums and @Axel_R_Huber on the effects of chemotherapy on normal blood cells and the development of therapy-related cancer. See: https://t.co/G4A4P3lzqI #MutationalSignatures
Our new study shows that data availability statements are not very useful; 1670 (93%) authors who indicated that data are available on request either did not respond or declined to share their data with us. Journal of Clinical Epidemiology: https://t.co/4IT2Dgphl4
@SerenaNikZainal@GenomicsEngland@_ADegasperi Congratulations! What a great resource.
Interestingly, SBS106 is very similar to the signature that's caused by the antiviral drug Ganciclovir that we identified. Interesting to also see it's found in Stomach and Skin! @BoxtelLab @peciflavia https://t.co/dO6ZnVknPo
Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature.
https://t.co/a68IkkTt33
An illustrated & updated tweetorial… [1/24]
Check out this special report in @CellStemCell: Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients. Lead author @BoxtelLab #AACR22 https://t.co/qbfdpLKDYl
Scientists hope a new study—which strongly links multiple sclerosis with Epstein-Barr virus—will spur the development of a vaccine against #EBV. https://t.co/n2xhI1t8qJ