Jeroen Bugter

Postdoc at Maastro Lab, Maastricht University 🇳🇱 | How cancer cells switch identity | Organoids, plasticity & signalling | Previously TUM 🇩🇪 & UMC Utrecht

[Jeroen Bugter @JeroenBugter]

This tutorial also marks the end of my NWO Rubicon fellowship at @TU_Muenchen. I've now joined the Maastro Lab at Maastricht University, where I'm looking forward to putting these approaches to work to tackle new biological questions!

[Jeroen Bugter @JeroenBugter]

You've established your organoid system. Now what?

Our new Tutorial in @NatureProtocols, with Simon Schafer & Roland Rad, is about that next step: matching your biological question to the right technique and protocol 🧫

[Nature Protocols @NatureProtocols]

New Article! Tutorial: interrogating biology using organoid technologies https://t.co/L8vryIQQGy

[Jeroen Bugter @JeroenBugter]

Four boxes tackle what often goes wrong in practice: growth factor requirements, CRISPR screening in organoids, building isogenic models and pitfalls in drug screening.

[Markus Tschurtschenthaler @MarTschu]

Our work is now published in @Nature.

We introduce the Mouse Cancer Cell Line Atlas (MCCA) and reveal deterministic, tissue-specific rules of KRAS-driven cancer evolution.

Huge thanks to the entire team & collaborators.
https://t.co/vjiwCcHnQl

[Eric Topol @EricTopol]

Tissue-specific basis for cancer evolution, as demonstrated with KRAS mutations
https://t.co/hREviFwhlV

[Nature Protocols @NatureProtocols]

New Article! Investigating non-proliferative cell states with inducible CRISPR screens https://t.co/kt5T5rJhwq

[Jeroen Bugter @JeroenBugter]

@arispapargyriou @MaxReichertMD @TU_Muenchen @natBME Fantastic work, congrats!

[Jeroen Bugter @JeroenBugter]

Great work by Michaela below 👇, discovery of an important new player in oncogenic WNT signaling and potential therapeutic target in APC mutant CRC. Happy to have contributed a tiny part to solving this puzzle 🧩

[Michaela Reissland @crypt_tales]

🥳I am beyond to finally share the story of my PhD out now: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer https://t.co/Rsut9zmUq2 Lets have a little look what we found: 🧵1/11

[Oncogene Journal @oncogenejournal]

USP10 emerges as a unique therapeutic target in APC-truncated #ColorectalCancer

🔬https://t.co/0LqpFmDeuO

@DiefenbacherL
#OpenAccess

[Hans Clevers @HansClevers]

Looking for PhD students/postdocs for my newly opened lab at the Institute of Human Biology of #Roche in Basel. We work on human lung, liver and gut #organoids. Send email + CV + motivation letter to [email protected] with header #IHB https://t.co/5Ki03fy4NH

[LifeScienceAlliance @LSAjournal]

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations @MadelonMaurice @JeroenBugter @UMCU_CMM https://t.co/IX87qT3mHW

[Jeroen Bugter @JeroenBugter]

Our paper exploring the different mechanism and selectivity of Frizzled regulation by the presumed paralog tumor suppressor genes RNF43 and ZNRF3 has been published! No time to read? I tried to summarize the main message in a one minute video 👇

[LifeScienceAlliance @LSAjournal]

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations @MadelonMaurice @JeroenBugter @UMCU_CMM https://t.co/WFgn2YQ6KB

[Matthias Lutolf @TheLutolfLab]

Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: https://t.co/0AvDkk9R3S Let’s dive in!