A must-read discussion on the statistical analysis of Selution De Novo by @ihtanboga . Lots of learning about analysis and narrative construction in the context of clinical trials. @DFCapodanno@PCRonline
This editorial highlights Marin et al.’s study showing how PCI reshapes coronary flow dynamics in humans, reinforcing key concepts of coronary autoregulation and the physiological basis of FFR.
#CoronaryPhysiology#PCI#FFR#InterventionalCardiology@JEscaned@Guusdewaard
Original paper : https://t.co/PLy11lgRKJ
I am not particularly surprised that the SELUTION DeNovo paper has not yet been published if this is the interpretation being promoted by the authors.
The noninferiority margin was 2.44%. In the intention-to-treat analysis, the upper bound of the risk difference for TLF was 2.38%, therefore technically meeting the criterion for noninferiority. However, in a noninferiority trial the per-protocol analysis carries greater weight, and in that analysis the upper bound of the risk difference is 2.63%, meaning that noninferiority is not achieved. To be precise, in noninferiority trials both intention-to-treat and per-protocol analyses are required, and concordant results are generally expected; when they diverge, the evidence for noninferiority is considered weak.
The authors now state that “the results of the per-protocol analysis did not confirm noninferiority, but they are similar to the intention-to-treat analysis in both direction and magnitude.” Well, where I come from we would say: “If my grandfather had wheels, he would have been a cart.”
@SmithElliotjs discussing algorithmatisation in interventional cardiology at #RENEWPCI often based on expert bias, can be difficult to apply, increasingly complex.
Working to frameworks may be a better approach- maintain cognitive flexibility
@ncurzen@mmamas1973 A great point Nick - we are now learning about the largest vascular compartment of the coronary circulation. But hopefully we’ll not fall into the nearly maniac obsession on cutoffs that dominates the pressure indices culture! (“should CFR be 2.0, 2.2 or 2.5?”)😓
Registration for RENEW PCI is open! Applications for educational grants are welcome from experienced and less experienced interventional.
https://t.co/SOsWOGK8ua
Looking forward to learning together at the on-line and face-to-face sessions in Madrid!
@shci@dcvalliance@BCIS_uk
‘Doctor duo’ - Father *102* yrs !! (🙏🏼) and son *70* yrs exercising together,😇!! What a blessing 😊
On this WORLD HEART DAY, pledge to stay fit and healthy and decrease your chances of heart attack.
If we can do it,so can you !‘ DONT MISS A BEAT’
FIT RAHO INDIA ….🇮🇳
🔄Introducing RENEW PCI 2025.
✅RENEW is an acronym whose first letter, R, stands for Rethink.
✅We believe that rethinking our PCI practice is key to identifying entrenched behaviours, considering areas for improvement, and paving the way for Personalised Interventional Care.
✅The work invested in the on-line module and over the following weeks will make the most effective use of our time in the RENEW PCI in-person meeting in Madrid/Spain.
✅This will be focused on interactive, live- and recorded case studies as well as practical hands-on activities.