Jose H. Ledo

Assistant Professor of Neuroscience and Neuropathology at Medical University of South Carolina . |

[Jose H. Ledo @Jhledo]

Thrilled to share our paper "An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains" , out now in @ImmunityCP ! Thread below by the super @AlonMillet !

[Alon Millet @AlonMillet]

Thrilled to cap off the year with the first paper of my PhD, out today in @ImmunityCP! We describe a population of exhausted-like microglia that accumulate in #Alzheimer's in both humans and mice in an age- and APOE4-dependent manner https://t.co/Nu6pfCTZAB Tweetorial below🧵

[Jose H. Ledo @Jhledo]

@bryan_johnson I have the same issue , have been treating it with cyclosporine eye drops to target the inflammation and warm compress 2x day , not back to baseline but improved a lot ...

[John Lukens @LukensJohnR]

Microglia are such a pain.
https://t.co/i1hs7h2Zhk

[Jose H. Ledo @Jhledo]

@VeenaPadmanaban @Nature Amazing work , truly ! Super congrats !

[Jose H. Ledo @Jhledo]

Super excited to share that we've got funding from @alzassociation to test a new therapeutical strategy for AD ! Big thanks to @alzassociation for this awesome opportunity!

#ALZFunded

[Jose H. Ledo @Jhledo]

Good opportunity for Senior PhD students and post docs

[Erin Gibson @ErinMGibson]

Senescent glia link mitochondrial dysfunction and lipid accumulation | Nature https://t.co/uJQ5DdNzKn

[Jose H. Ledo @Jhledo]

@Giovann35084111 Eventually they will understand , may take sometime though. Keep up the great work sir .

[eLife - the journal @eLife]

Cutting-edge miniature two-photon microscopy follows the structural dynamics of microglia in the somatosensory cortex of freely moving mice across the sleep/wake cycle. https://t.co/WdASTWyof2

[Jose H. Ledo @Jhledo]

Congrats to my friend Mauricio @Mauricio_Neuro and @KlannLab , great work guys !🚀

[Klann Lab @KlannLab]

So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. https://t.co/B8w9chSpDE. Congratulations Mauricio!

[Klann Lab @KlannLab]

So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. https://t.co/B8w9chSpDE. Congratulations Mauricio!

[Jose H. Ledo @Jhledo]

@KlannLab @Mauricio_Neuro Great Job Mauricio and Klann Lab !! You guys are rock stars ! 🚀

[Jose H. Ledo @Jhledo]

TIMely connections: APOE4, aging, and Alzheimer’s: Immunity https://t.co/k52rsqhkni

Very Nice Preview of our work by Qingyun Li.

@ImmunityCP

[Immunity @ImmunityCP]

An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains https://t.co/iRxmJqtADZ

[Jose H. Ledo @Jhledo]

@andrebafica @ImmunityCP @AlonMillet Thanks a lot irmao !

[Jose H. Ledo @Jhledo]

Thrilled to share our paper "An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains" , out now in @ImmunityCP ! Thread below by the super @AlonMillet !

[Alon Millet @AlonMillet]

Thrilled to cap off the year with the first paper of my PhD, out today in @ImmunityCP! We describe a population of exhausted-like microglia that accumulate in #Alzheimer's in both humans and mice in an age- and APOE4-dependent manner https://t.co/Nu6pfCTZAB Tweetorial below🧵

[Jose H. Ledo @Jhledo]

@LukensJohnR @AlonMillet Thanks a lot , John @LukensJohnR ! Wishing you a fantastic 2024 !

[Jose H. Ledo @Jhledo]

@neuro_MUSC 🔥🚀🎉

[MUSC Department of Neuroscience @neuro_MUSC]

2024 Neuroscience Department Faculty photo! What a great group of colleagues! @MUSC_COM @MUSChealth

[Jose H. Ledo @Jhledo]

@SchaferLabUMass @ImmunityCP @AlonMillet Many Thanks @SchaferLabUMass !!

[Jose H. Ledo @Jhledo]

@Mauricio_Neuro Thanks a lot mano ! 🤟🏽🤟

[Jose H. Ledo @Jhledo]

@danmucida @ImmunityCP @AlonMillet Thanks a lot mano véi !🙌🙌🏽