Klann Lab

Neuroscience lab investigating the molecular mechanisms of memory and how these mechanisms are disrupted in a variety of cognitive disorders.

[Klann Lab @KlannLab]

Check out @prerana123's exciting paper on sex-specific differences in anxiety-like behaviors in TSC. Amazing amount of work using multiple approaches. Many thanks to all of our collaborators!

[Dr. Prerana Shrestha @prerana123]

Thrilled to share our new work on the neural mechanisms underlying pathological anxiety in Tuberous Sclerosis complex. Great teamwork from @neuro_living, @Lawdex01, @RodrigoTrianaD2, @ksanagustinr, @Mauricio_Neuro +others in @ShresthaLab & @KlannLab. https://t.co/sIKnvt9wOB (1/n)

[Klann Lab @KlannLab]

So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. https://t.co/B8w9chSpDE. Congratulations Mauricio!

[Klann Lab @KlannLab]

@DrSharma_V @SonenbergLab @AKhoutorsky @Neurosenblum @Masha_P_ @wesparkhealth Congratulations on the lovely work Vijen!

[Klann Lab @KlannLab]

Big week for @Muhaned711 and the lab. On Monday, his first, first author paper was published in PNAS. Today, he gave an outstanding presentation and successfully defended his Ph.D. thesis. Muhaned rocks - we are all proud to have had the opportunity to do neuroscience with him!

[Klann Lab @KlannLab]

Excited to share @Muhaned711's now published work describing the impact of epilepsy- and ASD-associated mutations in EEF1A2 on de novo translation, elongation, tRNA-binding, and actin bundling. Congratulations Muhaned! https://t.co/pSfc2V1GKq

[Klann Lab @KlannLab]

@superkash @denisejcai @DrJessicaAlapin Thanks Tom!

[Klann Lab @KlannLab]

Delighted to share @DrJessicaAlapin's exciting work on an optogenetic tool that can be used to block eIF4E-dependent translation in specific cell types in the brain. Many thanks to all former/current lab members for their help in pushing this through! https://t.co/4QfIIp1RcT

[Klann Lab @KlannLab]

@RuggeroDavide @DrJessicaAlapin Thanks Davide!

[Klann Lab @KlannLab]

@angalus_d @DrJessicaAlapin Thanks Sulagna!

[Klann Lab @KlannLab]

Thrilled to share @fran_longo17's latest work describing cell type-specific disruption of striatal circuitry in FXS. Many thanks to our collaborators in the labs of @CarterAG, @BagniLab, & @NicTritsch - sometimes it takes a village! https://t.co/K3WEH8UPTB

[Klann Lab @KlannLab]

@Neurosenblum @Mauricio_Neuro Thanks Kobi!

[Klann Lab @KlannLab]

Really excited to share @Mauricio_Neuro's latest work, where he describes a novel mechanism for eIF2alpha dephosphorylation in response to plasticity-inducing stimulation, answering a long-standing question in the field of neuronal translation. Congrats! https://t.co/D6VRtU3eYI

[The Bagni Lab @BagniLab]

Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms underlying neurodevelopmental deficits using🪰and 🐭. #postdoc #neuroscience #DNF
Send CV, Cover letter and 3 referees by August 1st, 2023 (see ad).

[Klann Lab @KlannLab]

Excited to share @Muhaned711's work, where he describes how three separate ASD- and epilepsy-associated mutations in the gene encoding eEF1A2 alter translation elongation, neuronal morphology, tRNA binding, and actin bundling. https://t.co/uPwYC9o0kV

[Klann Lab @KlannLab]

Happy to share @fran_longo17's work describing how cell type-specific changes in striatal MSNs drive repetitive behaviors in FXS mice. Many thanks to @CarterAG, @NicTritsch, & @BagniClaudia labs for sharing their expertise! https://t.co/4JwEFKHtoe

[Dirk H. Trauner @DirkTrauner]

Check out our paper on the optical control of translation with a puromycin switch - in neurons! A collaboration with @tongil_ko @KlannLab @mo_hannes https://t.co/VzEOXs31by #ribosome #photopharmacology #translation #puromycin

[Dr. Prerana Shrestha @prerana123]

Thrilled to share our review on the modulation of emotional and social behaviors by oxytocin
signaling in limbic network!! It was great fun working on this together with @RodrigoTrianaD2, Sayali Ranade, Jahel Guardado, @LeDouxScience and @klannlab. https://t.co/rwZmRUcaw6

[Emory Genetics @EmoryGenetics]

Stephen T. Warren Memorial Symposium Nov 29-30, 2022 @EmoryMedicine -- honoring giant in #fragilex + repeat disorders field! More speakers announced including @nelsondl @EricTWang @KlannLab @SusanLAckerman1 Registration link: https://t.co/V0VnT1kUI3

[Klann Lab @KlannLab]

Today at @NYU_CNS, @erin_schuman gave the Valle Foundation Visiting Professor Lecture, where she discussed her groundbreaking work on local neuronal translation. Erin's talk was amazing - we are very excited to host her for an entire month here in NYC!

[Klann Lab @KlannLab]

The EMBO Workshop on RNA Localization and Local Translation held in Sant Feliu De Guixols, Spain concluded today. What a great meeting! Many thanks to ⁦⁦@BassellLab⁩, ⁦@ChaoLabFMI⁩, Anne Ephrussi, and Geraldine Seydoux for organizing!