Ji-Hyun Lee Lab

Gastric Stem Cell/ Mouse Genetic Model/ Regeneration/ Physiology / Tumorigenesis/ Organoid

[Ji-Hyun Lee Lab @JihyunLab]

Jaehun Lee from our team won a poster award at an international symposium in Japan! Huge congrats!!

[Ji-Hyun Lee Lab @JihyunLab]

🧬 Early gastric cancer cells can grow on their own.
Excited to share our new work published in Molecular Cancer: https://t.co/et3EqBXU3n
We show that MAPK activation (KRAS/HER2) drives autonomous WNT signaling via WNT7B, allowing gastric cancer cells to escape from their niche.

[Organoid News @organoidscience]

Today in @CellCellPress!

Scientists at Peking University (@PKU1898) detailed the spatiotemporal and genetic lineage differentiation of the endoderm at single-cell resolution.

🔎 Discover their findings: https://t.co/sgaLmZz0YN

[Developmental Cell @Dev_Cell]

Online now: mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos https://t.co/6yYtVsnNug

[Anna Obenauf @obenaufa]

Thrilled to share that our paper https://t.co/rHqjGXGRVk is featured in a fantastic Nature News & Views piece by @ThomasTueting! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. https://t.co/jsGF3MzRHW 👀👉 https://t.co/uJ55116T55

[Ji-Hyun Lee Lab @JihyunLab]

Postdoc position in Singapore! RNA modifications and epitranscriptomics for cell fate reprogramming. :) For more details, please visit Jon's lab webpage. 😊

https://t.co/fMgbVERpj6

[Hans Clevers @HansClevers]

Tomo Mizutani & Matteo Boretto selected 4 spontaneous colon #cancer mutations by sequential withdrawal of growth factors from mismatch repair-deficient #organoids. Mutations resemble those of Lynch syndrome & MSI-H patients tumors. https://t.co/FKokUczHGk

[Waggoner Lab @LabWaggoner]

TGF-β and RAS jointly unmask primed enhancers to drive metastasis @CellCellPress @LabMassague
https://t.co/iBIF9Abycl

[Matthew D. Park, PhD @MatthewD_Park]

Thrilled to share our first study on aging from @MiriamMerad lab @IcahnMountSinai @TischCancer @SinaiImmunol in which we demonstrate how aging promotes cancer. We show that: (1/n)
https://t.co/jhee5GZaCE

[Kurt Schmoller @SchmollerLab]

#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: https://t.co/oSmHKzWzMv @YagyaChadha @arohikhurana1

[Colinda Scheele @ColindaScheele]

Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: https://t.co/VmJdPNt7AW 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab

[Developmental Cell @Dev_Cell]

Online now: Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration https://t.co/FHsgpR4K7R

[Waggoner Lab @LabWaggoner]

Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome @NatureGenet @yang_i_li
https://t.co/r5MfnmC1I2

[Ji-Hyun Lee Lab @JihyunLab]

I am greatly honored to be a part of this paper! :)

[Ji-Hyun Lee Lab @JihyunLab]

Do you know how the injury response is resolved after regeneration? We found a nuclear regulator Phf16 that reinstates homeostasis after tissue regeneration upon intestinal injury. Find more details from the following link: https://t.co/SUR9uiVfS7

[Ji-Hyun Lee Lab @JihyunLab]

Do you know how the injury response is resolved after regeneration? We found a nuclear regulator Phf16 that reinstates homeostasis after tissue regeneration upon intestinal injury. Find more details from the following link: https://t.co/SUR9uiVfS7

[Ji-Hyun Lee Lab @JihyunLab]

https://t.co/W5NakBVEoA
live imaging of Kras G12D-driven tumorigenesis in the hair follicle.

[Maple Adkins-Threats @Dr_MadThreats]

Beyond elated to drop our new hit on the latest @CellStemCell album: “Zero to Hero: ERRgamma trains gastric stem cells to be parietal cells”. Using new mouse models and cell lines, we explore how ERRg regulates acid-secreting parietal cells regeneration from stem cells!!

[Fusion Conferences @Fusion_Conf]

The sun is out for Day 3 of #Stemgastro24. Many exciting talks to look forward to with the poster awards & gala dinner this evening 🕺💃

[Juhyun Kim @juhyunk_]

Mapping genotypes to chromatin accessibility profiles in single cells https://t.co/VV1YIOuHDJ #journals #feedly

[David R. Liu @davidrliu]

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
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