Jason Chan

Movement disorders neurologist @Fraserhealth. Fellowship @UFMDC. Residency @DCNSNeuro. MD/PhD @SchulichMedDent. Cognitive and systems neuroscience.

[Jason Chan @jlchan]

@AbhiLenka11 @MichaelOkun @FixelInstitute @AVCarpentier @MatthewRemz Thanks @AbhiLenka11, congrats to you as well!!

[Jason Chan @jlchan]

@AMahajanMD @MichaelOkun @FixelInstitute @AVCarpentier Thank you @AMahajanMD!!

[Jason Chan @jlchan]

Neat study suggesting "the existence of a canonical layer-based and frequency-based mechanism for cortical computation" across primates - macaques, marmosets, and humans. Higher frequency LFP activity in superficial layers, lower frequency LFP activity in deeper layers.

[Alex James Major @alexjamesmajor]

Very excited to share my co-first author paper in Nature Neuroscience! https://t.co/5EcMgslBsq

We show there is a pattern in LFP power that can be used to identify superficial vs deep cortical layers. This pattern was found in over 14 cortical areas and across species!

[Andreas Horn @andreashorn_]

Excited about this ‘review of all reviews’ about thalamic DBS for tremor by @c_neudorfer. In a new tour de force article, Clemens covers … 🧵1/N

https://t.co/qPwwCDaMDg

[Michael Okun @MichaelOkun]

How small are the targets we aim at for deep brain stimulation and lesion therapy for #Parkinsons, movement and neuropsychiatric disorders? I describe them to students as 'miniscule.' Great new paper by @jlchan and @JWongggMD @FixelInstitute which shows the comparison of the common targets.
Key points:
- Everyone who performs brain surgery and everyone considering this type of brain surgery should appreciate the tiny size of the targets.
- It is remarkable that we have in 'modern medicine' been able to precisely target in a reasonable manner.
- We are learning, as these authors share, that the targets of the future may not be these grey matter structures but rather fiber connections.
My take: Take a moment and appreciate how precisely we can target these tiny brain regions and change the circuit dynamics to improve symptoms of human disease. It is truly remarkable. Also, now appreciate how easy it to miss the target or fiber tract and if you don't respond it is reasonable to ask 'did we miss?' and to troubleshoot.
https://t.co/tNFxIO0Oro @DBSThinkTank @leaddbs @PdAvengers

[Erik Middlebrooks, MD @EMiddlebrooksMD]

Check out this new review of neuromodulation for mood disorders led by awesome @UFMDC fellows @jlchan & @AVCarpentier! @JWongggMD @MichaelOkun @EMiddlebrooksMD #DBS #depression #ConnectomeSurgery
https://t.co/wgNYrWa5zW

[Andrew Pruszynski @andpru]

I have to say that @MarkChurchland took it to another level here. I feel this is required watching for anyone in systems neuroscience. Pretty stoked to have had the chance to introduce him and this talk.

[Jason Chan @jlchan]

@UFMDFellowship @SfNtweets @FixelInstitute @MichaelOkun Photo credit @drjfxd, who has been a part of my science journey from the very beginning! Mentorship and teamwork are key to doing science.

[Jason Chan @jlchan]

Great science and discussions at #SfN2023, as always!

[UF Movement Fellowship @UFMDFellowship]

Our senior fellow @jlchan is currently sharing captivating preliminary data at #SfN23, shedding light on the relationship between local field potentials and cognitive performance.🧠We couldn't be prouder of his groundbreaking research! 🤩@SfNtweets @FixelInstitute

[Jason Chan @jlchan]

Noninvasive bilateral striatal theta-burst transcranial electrical temporal interference stimulation (tTIS) in humans increases striatal and motor network BOLD activity and facilitates motor learning @UPHUMMEL_EPFL: https://t.co/Kj6LOV5o5L @DBSThinkTank

[UF Movement Fellowship @UFMDFellowship]

We are so proud and excited our own @ShuklaWagle from @UFMDC is part of the expert panel of Video Challenge #MDSCongress! Amazing🤩

[Vikram Karnik @vkarnik1]

So proud of friend and colleague @DrVeronicaBruno for showing us her “magic” in the Video Challenge at the @movedisorder #MDSCongress in Copenhagen. @DCNSNeuro

[Jason Chan @jlchan]

Inferior colliculus may play a role in paradoxical kinesia in Parkinson's disease: https://t.co/jRvLM6vux3

[Jason Chan @jlchan]

Locomotion is context dependent - @KiehnLab at #MDSCongress @movedisorder Pedunculopontine nucleus (PPN) and cuneiform nucleus (CnF) may support slow, explorative locomotion and fast, escape locomotion respectively https://t.co/eVVQjhcqaA

[Jason Chan @jlchan]

Hej København! Hej #MDSCongress 2023! @movedisorder @UFMDFellowship

[Richelle Flanagan 💚💚💚💚 @RichelleFlan]

The reality is pwp worldwide don’t have access to the main treatment of Levodopa let alone access to DBS @TaniaPa08474924 @PdAvengers @SoaniaMathur @ParkinsonAfrica care for PwP is globally inequitable

[Jason Chan @jlchan]

Device-aided therapies, including DBS, increasingly needed as # of Parkinson's patients increases. However, not all "are approved nor realistically available worldwide, due to financial limitations, resource capacity and local expertise." @DBSThinkTank
https://t.co/8R5RP1ZCAX

[UF Movement Fellowship @UFMDFellowship]

🖥️⚡️@littleneuro did an overview of data-driven adaptative DBS.

To continue the discussion, read that great article in @movedisorder that highlights advances and challenges as aDBS moves from experimental to clinical practice. @neumann_wj @DBSThinkTank

https://t.co/0TYPIcxQdA

[Jason Chan @jlchan]

Whirlwind tour of gait disorders at Aspen with @MichaelOkun. Nonnekes et al. identified 59 compensation strategies for gait impairment in Parkinson's disease and classified the strategies based on potential mechanisms: https://t.co/rkPkn45H9G

[UF Movement Fellowship @UFMDFellowship]

Poll: Do you think gluten ataxia exists? 🥖🥨🍞🚶‍♂️

Antigliadine antibodies have been found in cerebellar ataxias as well as in a variety of neurological disorders.

@MarkHallett007 presents the evidence and invites us to choose a side. What is yours?