Jorge FdCD

[Jorge FdCD @jorgefdcd]

https://t.co/4jEFQgFlnh

[Jorge FdCD @jorgefdcd]

Our work has been selected as a Spotlight at @genbio_workshop @icmlconf

[Jorge FdCD @jorgefdcd]

How can we steer protein language models toward specific traits, without losing sequence diversity?

In our new preprint, we introduce Iterative Lookback Monte Carlo (ILMC)—a training-free sampling strategy that balances generation quality, steering constraints, and diversity.

[Jorge FdCD @jorgefdcd]

ILMC delivers highly diverse protein designs, including variants with up to a 12°C increase in predicted melting temperature.

Full paper: https://t.co/cyOu1ZBr7I

[Jorge FdCD @jorgefdcd]

How can we steer protein language models toward specific traits, without losing sequence diversity?

In our new preprint, we introduce Iterative Lookback Monte Carlo (ILMC)—a training-free sampling strategy that balances generation quality, steering constraints, and diversity.

[Jorge FdCD @jorgefdcd]

Just published in PNAS: https://t.co/RXIeELHicL

[Jorge FdCD @jorgefdcd]

New preprint: Cross-individual translation of spontaneous zebrafish brain activity through a shared latent representation

[Jorge FdCD @jorgefdcd]

https://t.co/YVuALp5gQw

[Jorge FdCD @jorgefdcd]

@disclosetv @grok verify, find original source

[Jorge FdCD @jorgefdcd]

@grok @NulliusJacques @dannyctkemp @grok Find original sources

[Jorge FdCD @jorgefdcd]

Teaching machines to design molecular switches https://t.co/JKdPkGfF9L via @physorg_com

[Jorge FdCD @jorgefdcd]

@simonmaechling 👋

[Jorge FdCD @jorgefdcd]

Link: https://t.co/tk8RdyVSrQ

[Jorge FdCD @jorgefdcd]

New preprint: Cross-individual translation of spontaneous zebrafish brain activity through a shared latent representation

[Jorge FdCD @jorgefdcd]

We develop latent-aligned RBMs, to uncover a common representational space from cell-resolved whole-brain recordings spanning several distinct larval zebrafish individuals.

[Jorge FdCD @jorgefdcd]

Link: https://t.co/iuaJLW0KdR

[Jorge FdCD @jorgefdcd]

New preprint: Design and experimental characterization of specificity-switching mutational paths of WW domains.

[Jorge FdCD @jorgefdcd]

We use energy-based generative models (RBM) to design full mutational paths connecting two natural proteins of different binding specificities, and verify experimentally that intermediate sequences stay functional.

[Jorge FdCD @jorgefdcd]

Just published in @NatureComms : Designing molecular RNA switches with Restricted Boltzmann machines. Full paper: https://t.co/yqKZUq3M0R

[Jorge FdCD @jorgefdcd]

Master internship position available, with possibility of PhD after. More details here: https://t.co/iYR3ra6RI9

[Jorge FdCD @jorgefdcd]

@Affinity Are you planning to make it available on the Mac App Store ?

[Jorge FdCD @jorgefdcd]

@Ji_Ha_Kim Love Obsidian ! Just curious, what plugins are you using?