Joyce

PhD student at National University of Singapore

[BioFINDER @biofinder_study]

We compared 10 p-tau blood assays in our latest paper in @Brain1878! P-tau217 is consistently better than p-tau181, mass-spect (MS) assays are better than best immunoassays, with MS p-tau217 reaching very high accuracy (AUC<0.93)!
https://t.co/tfc4lJxZKw

[Sylvia Villeneuve @sylv_villeneuve]

Our most important clinical paper so far. In the @prevent_ad, 60% of our cognitively unimpaired participants with amyoid and tau PET binding developed MCI in ~2 years, a number that increased to 80% in those with hippocampal atrophy. The findings are replicated in 3 cohorts.

[Thomas K. Karikari @TommyKakari]

New paper in @NatRevNeurol
We present state-of-the-art review of recent developments in plasma phospho-tau:
- Analytical methods 🩸
- Molecular interpretation 💉
- Clinical use 🩺

https://t.co/tTQzEPlSFa

[Nicholas Ashton @NicholasAshton]

I am very pleased to (finally!!) share this paper co-authored with @andrealessa @pedrorosaneto in @eBioMedicine

More evidence that #pTau231 changes very in #AD continuum – associated with subtle regional #Aβ deposition. #pTau217 shows ⬆️ fold-changes in symptomatic disease.

[Memory Aging & Cognition Centre (MACC) Singapore @AgingMacc]

We're ramping up recruitment for our multi domain lifestyle intervention study to prevent cognitive impairment and physical frailty!

[Trends in Neurosciences @TrendsNeuro]

‘Untangling the relationship between microglia and tau in Alzheimer’s disease’

@TrendsNeuro ‘Spotlight’ by Samantha M. Rossano & William C. Kreisl

https://t.co/AUVawOTdhw

discussing Pascoal et al. @NatureMedicine, @TharickAPascoal @PedroRosaNeto

https://t.co/6AbLpRS9oG

[Nicholas Ashton @NicholasAshton]

Plasma #GFAP detects #amyloid burden, independent of #Tau, differently to CSF GFAP and does it very early!

A really fun and important collaboration!
@andrealessa @Marta_Mila_ @VrillonAgathe @pedrorosaneto @M_SuarezCalvet @Imaging_AD @goteborgsuni @fpmaragall

[Marta Milà Alomà @Marta_Mila_]

👇Our latest work on synaptic biomarkers in #preclinical #Alzheimer, showing they increase in the earliest stages and differently associate with risk factors and neurodegeneration

Thanks to @M_SuarezCalvet and all coauthors from @uniofgothenburg and @fpmaragall !!

[BioFINDER @biofinder_study]

The BioFINDER team is proud to present the first large head-to-head study comparing different plasma Aβ assays. The study found that certain IP-MS methods clearly outperforms most other assays and should preferably be used in future studies and trials.
https://t.co/F0J2AhIrYT

[Nicholas Ashton @NicholasAshton]

The World Alzheimer Report launches tomorrow. Please join the webinar to hear about latest in diagnosing dementia.

Very pleased to have contributed to the report with @andrealessa @TommyKakari as we focus on fluid biomarkers #WorldAlzDay 🩸🔬🥼

[Joyce @joycejoy22]

@NicholasAshton @RikOssenkoppele Congratulations!

[Nicholas Ashton @NicholasAshton]

It is hard to summarise the different technologies, advances and results in the explosion of #blood #biomarkers for #Alzheimers – but this does a pretty good job of doing so!

Congratulations to @joycejoy22 et al, it was fun to work with you on this!

https://t.co/oKF4fhB3tR

[Memory Aging & Cognition Centre (MACC) Singapore @AgingMacc]

Congratulations on emphasising the close links between brain health and heart health

[Memory Aging & Cognition Centre (MACC) Singapore @AgingMacc]

From finger to singer : establishing a global evidence base for multiple lifestyle interventions

[Nicholas Ashton @NicholasAshton]

AlzBiomarker v3.0 is live!!
https://t.co/1aJjraWbL2

✅case vs control update
✅multi-disorder
✅3700 cohorts & 238 meta-analyses
....all on #CSF & #plasma #biomarkers

Fantastic to work with all @alzforum and, of course, Kaj Blennow & Henrik Zetterberg on this important project

[RikOssenkoppele @RikOssenkoppele]

Pleased to share our multicenter study in >1400 persons across the #Alzheimer's disease spectrum, showing that #tau #PET is a promising #prognostic marker in #preclinical and #prodromal AD - outperforming #amyloid PET and #MRI, https://t.co/4Wok1MpwbF @JAMANeuro @OskarHansson9

[Brain @Brain1878]

Pereira et al. show that plasma Aβ42/40 is an independent predictor of future amyloid accumulation, whereas plasma P-tau217 is an independent predictor of tau accumulation, brain atrophy and cognitive decline. https://t.co/HISmPJSImX

[Memory Aging & Cognition Centre (MACC) Singapore @AgingMacc]

Well done @LutingPoh and @garriearumugam for showing that Intermittent Fasting attenuates the inflammatory response and cell death pathways in the brain following chronic hypoperfusion in a mouse model of vascular cognitive impairment (VCI).
https://t.co/oxHXMdXWAa!

[Brain @Brain1878]

Using advanced brain imaging techniques, Walsh et al. provide evidence of neuroinflammation and increased blood-brain barrier permeability in patients with cerebral small vessel disease. Both processes could serve as potential therapeutic targets. https://t.co/BipkrXG5dS

[Memory Aging & Cognition Centre (MACC) Singapore @AgingMacc]

Congrats to our PhD student Luting and close collaborator @garriearumugam for publishing: "AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia" in Mol Psychiatry. Read here: https://t.co/zVlcfJGfit