Jake Robson-Tull

Doing drug discovery things. Scientist at Schrodinger. Views are my own.

[Jake Robson-Tull @jrobsontull]

@united I think we should normalize bunk beds next

[Jake Robson-Tull @jrobsontull]

This will be available in an upcoming software release of the Schrödinger suite. We have exciting plans to continue enablement of macrocycle drug discovery. Read more in our preprint: https://t.co/TOHFQu3uBj 🧵7/7

[Jake Robson-Tull @jrobsontull]

Excited to share a recent preprint from my work at Schrödinger! We outline a new approach for flexible docking of macrocyclic ligands and benchmarked this on a manually curated dataset of macrocycle-receptor complexes. 🧵1/7

[Jake Robson-Tull @jrobsontull]

We also make our dataset publicly available so that others in the field can use it for further testing of computational tools for macrocycles. 🧵6/7

[Jake Robson-Tull @jrobsontull]

@generalx @VadimYuryev air

[Nik Sergejevs @NickoSunway123]

Our latest review on the transmembrane domain recognition during protein quality control is now available! Enjoy the read:

https://t.co/dQyKV3aH06

[Jake Robson-Tull @jrobsontull]

@KlugYoel @Dunn_School Good luck in your next steps! Hope you and the family are doing well

[Gina El Nesr @ginaelnesr]

Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?

@HWaymentSteele and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!

🧵

[Jake Robson-Tull @jrobsontull]

@LazarusLong13 FYI, this study reports correlation with dementia, not cause. Still something that should be investigated further though!

[Niko McCarty. @NikoMcCarty]

Just now: @arcinstitute and @nvidia release Evo 2, the largest AI model for biology. It is fully open-source.

Evo 2 can predict which mutations in a gene are likely to be pathogenic, or even design entire eukaryotic genomes.

We covered it in @AsimovPress! Check it out 🔻

[Google AI @GoogleAI]

Today we introduce an AI co-scientist system, designed to go beyond deep research tools to aid scientists in generating novel hypotheses & research strategies. Learn more, including how to join the Trusted Tester Program, at https://t.co/1eqmTTZOLr

[Nik Sergejevs @NickoSunway123]

Excited to share my first, first-author manuscript on the role of Signal Peptide Peptidase in membrane protein quality control. Massive thanks to our collaborators, @Marius_Lemberg @donem_avci @RobinCorey1 and postdoc @MichaelvdWeijer @Dunn_School

https://t.co/5sTmW6HmqU

[Michael van de Weijer @MichaelvdWeijer]

Just out from the Carvalho lab!!! Yours truly, @NickoSunway123 and colleagues together with @LuLin_Jiang and @TrostLab
discover a new role for the RNF185-Membralin ERAD complex in regulating Tapasin assembly with the PLC! Get it while it's hot!
https://t.co/LgTBNAhi9F

[Lea Lab @LeaLabTweets]

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: https://t.co/ki0UnetrIw

[Jake Robson-Tull @jrobsontull]

@_ann_nguyen Really clean and looks great on mobile

[Jake Robson-Tull @jrobsontull]

@Kim_Hanseong @dabiophysicist Have you tried additives during grid preparation?