LuLin Jiang

Senior Scientist, BAI-Altos Labs, Proteostasis, astrocytes, microglia, disease mechanisms of AD and ALS. She/her.

[Karl Miller @knmiller71]

Now online, the main paper from my postdoc! A huge thank you to my coauthors, the Adams lab, and Peter @AdamsBioAging

https://t.co/U7DHFWXBqA

[Alice Ting @aliceyting]

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.

[International Society for Molecular Neurodegen. @ISMND1]

ISMND's Publication & Science Programs Officer and @MolNeuro Senior Editor Dr. Hongmei Li is at the ISMND booth (#1848) at #SfN2024 as part of our 'Meet the Editor' sessions! Catch her from 2pm-3pm today 🤓

[LuLin Jiang @LuLin_Jiang]

Wonderful collaboration with @MichaelvdWeijer and the Carvalho group! We identify a new substrate, Tapasin, for RNF185-Membralin ERAD complex and a novel role of the complex in regulating the antigen presentation 🎉🎉🎉

[Michael van de Weijer @MichaelvdWeijer]

Just out from the Carvalho lab!!! Yours truly, @NickoSunway123 and colleagues together with @LuLin_Jiang and @TrostLab
discover a new role for the RNF185-Membralin ERAD complex in regulating Tapasin assembly with the PLC! Get it while it's hot!
https://t.co/LgTBNAhi9F

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

A new study by Nirmalya Dasgupta in the lab 10.1016/j.molcel.2024.08.006 Nirmalya shows that histone chaperone HIRA and PML collaborate to control the SASP of senescent cells via cGAS/STING. Great work and congratulations, Nirmalya! https://t.co/e7wOepFD3A

[International Society for Molecular Neurodegen. @ISMND1]

We are excited to announce Dr. Aaron D. Gitler @Stanford as our next ISMND Science Webinar speaker!

Title: Expanding mechanisms and therapeutic targets for neurodegenerative disease

August 15, 2024
1pm-2pm (ET)
Host: Philip Wong, Ph.D.
Register: https://t.co/CrpaJKTPmJ

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Registration closes August 12 for this great meeting!

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

New study led by talented post doc in the lab @Aaron_Havas : 1) aged tissues at increased risk of cancer due to "precarious balance"; 2) age-activated IFN signaling is an adaptive response to prevent cancer in older tissues, but w/ maladaptive consequence. https://t.co/7matXAcget

[LuLin Jiang @LuLin_Jiang]

@kumsta @Nia Congratulations 🎉🎊🍾!!!

[John Lukens @LukensJohnR]

Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress https://t.co/E7dqyLYoty

[Peter Adams🇪🇺🇺🇳 @AdamsBioAging]

Very insightful study! What are the non-genetic non-environmental causes of variation in lifespan? This is well-documented in genetically identical worms living in identical environment (same dish). The don’t all die at the same time. Why not? https://t.co/MD8CcNOAoC

[John Lukens @LukensJohnR]

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis @NatureNeuro
https://t.co/m1paBdcLSR

[Gan Lab @LiGanLab]

Super excited to announce our latest work in @MolNeuro! We generated new anti-acetylated-tau-K174 antibodies that effectively mitigate neurobehavioral impairments and reduce pathology in PS19 mice— alone and in conjunction with TBI. (1/5) Details here: https://t.co/lpNL5Rj6Lc

[Nature Neuroscience @NatureNeuro]

After focal CNS injury, local mature #astrocytes dedifferentiate, proliferate and become transcriptionally reprogrammed; these wound repair astrocytes are the predominant source of neuroprotective borders that re-establish CNS integrity around lesions

https://t.co/lnPmGMATbb

[Hanna Salmonowicz @HSalmonowicz]

I am honoured to coauthor one of my favourite papers of all times when it comes to #mitochondria #ageing and #senescence! https://t.co/N4O1DPxVtb

So things are not always as we dogmatically assume. Mitochondrial and "-phagy" dysfunctions are reported to occur with ageing...

[Wei Cao @weicao_phd]

Happy to share our new publication: Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging | Molecular Neurodegeneration | Full Text https://t.co/BJGcSSaBIy

[John Lukens @LukensJohnR]

Neurodegeneration and demyelination in multiple sclerosis: @NeuroCellPress https://t.co/ZrpV19DZrb

[Nature Cell Biology @NatureCellBio]

💫NEW: Feng & co show that the major nucleoid protein TFAM interacts with cytoplasmic LC3B during oxidative or inflammatory stress to attenuate #mitochondria DNA-induced #inflammation via the #cGASSTING pathway.
👉https://t.co/gDNeYRvt2s
https://t.co/o2MnXNucbO

[John Lukens @LukensJohnR]

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis: @cell https://t.co/RCuGi4nPxM

[Kavitha Scranton @KavithaSci]

Astrocytes remember...from @QuintanaLabHMS @KeystoneSymp #KSNeuroImmune24 discussing his @Nature paper https://t.co/qSXItyfaVl.
Read the @ImmunityCP Spotlight of his work here "Astrocytes remember inflammation" https://t.co/vdIhQFf344