francisco Kaballero

[Enséñame de Ciencia @EnsedeCiencia]

Se trata de la rapamicina o sirólimus, una lactona macrocíclica aislada del Streptomyces hygroscopicus, que se encuentra en el suelo de Rapa Nui. Fue descubierta en los años 60 por científicos canadienses y se utiliza como un potente antifúngico.

[SINC @agencia_sinc]

💊 Evitar los dulces mientras se toma antibióticos podría ayudar a proteger la microbiota

Un equipo ha observado la relación entre los alimentos ricos en azúcares y una mayor alteración de la salud intestinal cuando se ingieren este tipo de medicamentos

https://t.co/FsERBWzXDg

[Dr. Javier Flores @farmacotips]

🚨ULTIMA HORA: Retatrutide logró reducción del ≥30% de su peso corporal confirma NEJM.

En TRIUMPH-1, publicado en NEJM, la dosis de 12 mg consiguió una pérdida media de peso del 28.3% a las 80 semanas y el 45.3% de los pacientes perdió ≥30% de su peso corporal.

Pero Lilly también está explorando otra estrategia: combinar eloralintide, un agonista del receptor de amilina, con tirzepatide logrando pérdida de peso de hasta 23.3% a las 48 semanas frente a 14.8% con tirzepatide 15 mg sola.

[New Scientist @newscientist]

Slashing sugar intake before antibiotics may save your microbiome https://t.co/Bmw3lqTAws

[Virginio Gallardo @virginiog]

Cometimos un error enorme al permitir que la industria de la tecnología educativa entrara y diera a cada niño una computadora o tablet
Los resultados son devastadores y tenemos que repensarlo
J. Haidt
No confundir enseñar habilidades digitales con dar dispositivos digitales

[SciTech Girl @scitechgirl]

🧬 Scientists Made Pancreatic Cancer Disappear — But There’s a Catch

What if one of the hardest cancers to treat could actually be pushed into permanent remission?

In a new study, researchers developed a combination treatment that completely eliminated pancreatic tumors in mice. Even more surprising, the tumors did not develop the usual resistance that often makes cancer treatment stop working.

The treatment attacks the cancer through three different biological pathways at once, making it much harder for tumor cells to escape.

But here is the important part: the results were achieved in mice, not human patients. Researchers say the treatment is not yet ready for clinical trials.

Another 2026 study found that a different three-part immunotherapy approach could also clear pancreatic tumors and create lasting immune memory in several mouse models.
So, is pancreatic cancer cured?
Not yet.
But scientists are discovering new ways to make this aggressive cancer vulnerable—and that could eventually change how it is treated.

Source: Centro Nacional de Investigaciones Oncológicas (CNIO). (2026). A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance. PNAS.

[Jonathan Chávez @JonathanNefro]

En diabetes tipo 2 con riñones normales (sin albuminuria y con TFG normal), los iSGLT2 o aGLP1, no tuvieron efecto al reducir el riesgo de deterioro de función renal a 5 años

Emulación de ensayo clínico

BMJ 2026
https://t.co/tGPZ4Jmq66

[Next Science @NextScience]

🚨 A SIMPLE NASAL SPRAY COULD CHANGE STROKE TREATMENT FOREVER

Scientists have created a powerful nasal spray that may reduce brain damage from strokes by up to 80%.

Instead of invasive procedures, the spray sends protective compounds directly to the brain through the nose within minutes. Early studies show it may protect brain cells, reduce inflammation, and improve recovery chances after a stroke.

Experts believe this breakthrough could one day allow stroke treatment to begin in ambulances or even before reaching the hospital.

Source:
University of Copenhagen. “Nasal Spray May Reduce Brain Damage After Stroke.”

[Medscape @Medscape]

Retatrutide, an investigational triple hormone receptor agonist that shows promise for weight loss in ongoing phase-3 clinical trials, is being sold openly across the internet and prescribed by licensed physicians online and in diverse clinical settings across the US, investigations have found.

The phenomenon of such easy access to a drug that's not approved anywhere for any indication is arguably without precedent. Patients are discovering the drug — a GLP-1, glucose-dependent insulinotropic polypeptide, and glucagon agonist — through social media, purchasing it from vendors online, and arriving at clinic appointments either asking about it or disclosing they are already using it.

News reports state that everyone from “shadowy online vendors” to physicians and nurses is illegally promoting the drug before it receives the FDA approval. Tap the link to read the full story. https://t.co/BIWkD6wGRv

[Medscape @Medscape]

With more patients using GLP-1 weight-loss medications, physicians are increasingly seeing patients who discontinued therapy because of cost, limited pharmacy availability, intolerable adverse effects, or loss of insurance coverage.

After patients discontinue medication, weight regain is common, and that may affect their mental health, confidence, and willingness to return for follow-up care.

Because the duration of GLP-1 therapy is often uncertain, physicians should begin discussions early so patients understand that long-term nutrition, activity, and behavioral strategies remain central to obesity management. Patients may need counseling about adequate protein intake, the need for resistance training to preserve lean mass, and higher-fiber diets to support satiety and cardiometabolic health. https://t.co/G07lf4JOc2

[Cronicas Medicas @CronicasMedX]

🧵 Hilo: CAR-T – Cuando los linfocitos se convirtieron en un fármaco vivo
1/
Durante décadas, el cáncer de la sangre se combatió con quimioterapia, radiación y trasplantes.
Armas potentes… pero ajenas al cuerpo.
Hasta que la medicina hizo algo distinto:
tomó las propias defensas del paciente, las reprogramó…
y las mandó de vuelta a cazar el tumor.
Esta es la historia de la terapia CAR-T. 👇

[Eric Topol @EricTopol]

In 2025, Keytruda (pembrolizumab) was the number one drug for global sales ~$32 billion, targeting PD-1, for cancer immunotherapy. But we didn't know precisely how it works until today @ScienceMagazine
https://t.co/uIt3jDXzWW
https://t.co/xnxlg6burf

[DW Español @dw_espanol]

Científicos revisaron un lote de atún. El 96 % tenía #gusanos

Los par��sitos del #atún listado pueden extenderse por distintos órganos y tejidos, incluida la parte que consumimos. (few) https://t.co/iY2aphGcej

[Lorenzo Ramírez @lorenzoramirez]

El "Internet de las Cosas" implica que los electrodomésticos espían a los usuarios. Cuando los investigadores denunciamos estos hechos los propagandistas occidentales culpan a los chinos de ser quienes sustraen nuestros datos, pero lo cierto es que también los servicios de inteligencia de EEUU están dentro de nuestras casas. Y desde hace mucho tiempo: https://t.co/pHyFUebba8

[Jose Vizner @Josevizner]

ÚLTIMA HORA: La FDA aprueba una pastilla que casi duplica la supervivencia en el cáncer de páncreas: de 6,7 a 13,2 meses en el ensayo clínico.

Ataca el gen KRAS, clave en este tumor y también en el de hígado y colon. Investigadores del Dana-Farber lideran el estudio. Se llama daraxonrasib.

[Eric Topol @EricTopol]

We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
https://t.co/iw1ceSbUvf

[Phys.org @physorg_com]

About 60% of human genes contain a newly decoded initiator sequence, after an AI model was trained on roughly 500,000 variants to predict where this gene-activation signal is present. @ucsandiego https://t.co/7umGkS67A2

[Lorenzo Ramírez @lorenzoramirez]

Harari es pieza clave del “mayor experimento psicológico y social de la historia de la humanidad”. Su trabajo es normalizar lo anormal, la profecía auto cumplida disfrazada de advertencia. Devils

[Medscape @Medscape]

A spoonful of unflavored gelatin mixed with warm water and consumed 15-30 minutes before a meal is being promoted on social media as “nature’s Ozempic.” But what's the truth behind the trend? https://t.co/LXFUUuAg7f

[SciTech Girl @scitechgirl]

🧬 The Egg That Never Came From a Chicken

What if your next “egg” never came from a chicken?
Scientists are now making real egg proteins using **precision fermentation**—engineered microbes produce egg proteins inside fermentation tanks, without hens. Companies such as Onego Bio and The Every Company are already using this technology in food products.

The FDA has reviewed the safety information for these proteins, and some are already appearing in baked goods and packaged foods.

With bird flu pushing egg prices higher, could lab-made egg protein become part of the future of food? The answer may be closer than we think.

Source:U.S. Food and Drug Administration. (n.d.). *GRAS notices*. FDA.