@biorxivpreprint IL-12 is preferentially released at synapses formed with T cells displaying higher T cell receptor affinity, providing a mechanism for selection of the most potent T cell @uppsalauni
https://t.co/FTECei1uSv 🇸🇪
I'm officially an expert in failing! I was asked to give the opening keynote today for a @CRUKCamCentre conference, speaking on the topic "Failing in Science"
For decades, we taught a simple rule: MHC I → CD8 T cells, MHC II → CD4 T cells.
Turns out, that’s incomplete.
MHC I doesn’t just help CD8s “see” cells — it also protects cells from CD4 T cell–driven killing.https://t.co/AB5OUxIWfH
Online now: Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading https://t.co/yf1sV7RmEa
Birui Pan, Chen Dong et al. @Tsinghua_Uni@Westlake_Uni identify Zbtb32 as a key promoter of terminally exhausted CD8⁺ T cell differentiation, enhancing cell cytotoxicity and anti-tumor function. This study valuable insights for cancer #immunotherapy. https://t.co/kpnl59MDAx