kanakaselvan

mostly in awe. here to stalk my intellectual crushes

[Max Marchione @maxmarchione]

Retatrutide phase 3 obesity trial just came out and the results are genuinely insane:

- 28.3% bodyweight lost on 12mg over 80 weeks
- 70.3 pounds on avg. or 31.9 kg
- 45.3% of patients hit 30%+ weight loss (this is bariatric surgery territory)
- 30.3% weight loss (85 lbs) at 104 weeks in higher-BMI patients
- 65.3% of 12mg patients dropped below the obesity BMI threshold
- 19% loss on 4mg over 80 weeks (47.2 lbs) with fewer dropouts than placebo (4.1% vs 4.9%)
- significant drops in blood pressure, triglycerides, non-HDL cholesterol, waist circumference, and hsCRP
- no cardiac or liver signals

Retatrutide is going to completely overshadow tirzepatide and semaglutide, and take the throne as the best-selling drug of all time.

[GRITCULT @GRITCULT]

Dostoevsky was 28 when they stood him in front of a firing squad. Blindfolded. Hands tied. He could hear the rifles being loaded.

At the last second a messenger on horseback arrived. The Tsar had commuted the sentence. The entire execution was staged. Psychological torture designed to break him.

It worked. He had a seizure on the spot.

They sent him to a labour camp in Siberia. 4 years. Freezing. Starving. Sleeping on wooden planks next to murderers. His epilepsy got worse. He had no paper. No pen. Nothing.

When he got out he was broke. His first wife died. His brother died. He inherited his brothers debts. He was so desperate for money he signed a contract with a publisher that would have given away the rights to everything hed ever write if he missed the deadline.

He wrote The Gambler in 26 days to make it. Dictated it to a 20 year old stenographer named Anna. Married her three months later.

Then the real work started. Crime and Punishment. The Idiot. Demons. The Brothers Karamazov. The greatest novels in the history of the Russian language. Maybe any language.

The man who stood blindfolded before the firing squad, who convulsed on the ground while soldiers watched, who slept next to killers in Siberia for 4 years, who was buried in debt and grief.

That man wrote: "every minute can be an eternity of happiness."

He earned the right to say it.

its never over. never give up fren.

[Conor Sen @conorsen]

In a media environment dominated by short-form video and slop, actually having watched hundreds of films or read a lot of books is a status marker showing you have an attention span.

[🕊️ @lichthauch]

Fatherhood is the end of philosophy. you can read every book ever written about meaning and purpose and discipline, but the moment a small human looks at you and believes you, everything you thought you knew burns down. because now you have to do it, not think it, not debate it, not post about it. the child watches your hands, what you do when you are tired, what you do when you are mad, what you do when nobody else is looking. that is your only sermon and you cannot fake it for one day because children are bullshit detectors made of flesh. if you are a weak man your son will know it before he can spell the word weak, and he either becomes you or becomes the opposite of you, both out of desperation.

[Bill Gurley @bgurley]

This is the key in my book. Find the thing where you get to practice as an artisan. It exists in all fields. It very might be your hobby. https://t.co/ZiwH5zJ2KC

[kanakaselvan @kanakaselvan]

fr. moved by the performance of jessie buckley. incredible movie.

[Zak @zakfilm]

When all is said and done, this scene in Hamnet stands out as one of the most moving experiences of the year. Chloe Zhao reminds you how powerful cinema can be in understanding the simplicity of human emotions that brings people together in the spirit of love for art and stories while navigating through grief and the difficulties of life itself.

[Marc Andreessen 🇺🇸 @pmarca]

My information consumption is now 1/4 X, 1/4 podcast interviews of the smartest practitioners, 1/4 talking to the leading AI models, and 1/4 reading old books. The opportunity cost of anything else is far too high, and rising daily.

[n0thing_man_ @TideWorn_73]

the years
grew wings
and flew away

[signüll @signulll]

your “will” isn’t what you consciously want, it’s the pattern that emerges from what you keep doing despite yourself.

[sophie @netcapgirl]

it’s on slack bro. it’s in the drive. i just put it in the notion bro i literally sent it to you on teams. did you check the airtable bro? it’s in the box bro. it’s single sign on, it’s on okta bro. no you need the yubikey. check your deel bro, it’s on gusto. check outlook bro

[signüll @signulll]

most ppl think capitalism reduces dependency on others because there is always an app or service for your problem but this isn’t the case… what capitalism at scale does is actually anonymizes dependency.

today you’re more dependent than ever on vastly more people. you simply just don’t know any of them. the medieval peasant depended on maybe 150 people & knew them all by name.

you depend on millions now & know zero of them.

[Tyler is finishing a book, slow to reply @TylerAlterman]

This made me go “holy shit” out loud. Might become my go-to example for talking about the predictive processing model of cognition

[TBPN @tbpn]

Investor @bgurley: "If I were using cynical words, I'd say [venture capital] hijacked the growth years of early IPO companies."

"Amazon went public below a billion in market cap. It's hard to fathom that today, with what we have going on here."

[signüll @signulll]

most people don’t realize how absurdly rare real connection is… how fragile, contingent, & wildly improbable it is to genuinely click with another human.

this is actually what makes it quite beautiful.

[Nornal Guy 🧙‍♂️ @theralkia]

Lana Del Rey is an artist for guys with extremely high testosterone

[Nornal Guy 🧙‍♂️ @theralkia]

A lot of people are like this

[kanakaselvan @kanakaselvan]

@willmacaskill Plato & George Washington

[Tim Urban @waitbutwhy]

Whenever I get to know someone who seems perfect, I end up disappointed. Whenever I get to know someone who I think is the worst of the worst, I'm pleasantly surprised. Angels and demons aren't real.