Proud of the work our team led by Dr Ethan Burns did looking at the NCDB ; octogenarians with lung cancer did significantly better with IO however significant disparities exist; much work still to be done, #LungCancer https://t.co/9sbfCjBq2z
CMV and Transplant. CMV memory resides in donor lymphocytes.
CMV IGG status and risk
D-/R-: Negligible chance of transmission
D+/R-: Transmitting CMV memory from D to R. Not bad
D+/R+: Could lead to reactivation
D-/R+: Worst. Last two should get prophylaxis with Letermovir.
Wow!
A witness just testified in front of Congress that the government has recovered “non-human” pilots from UFOs.
What. A. Time. To. Be. Alive. https://t.co/dWydIrRBYb
Myeloma drugs — Dosing and schedule
What I do in practice #MedTwitter
1. Dex: 40 mg once a week age <70; 20 mg if age >70 or frail
Stop Dex at around one year if good response.
Days 1-4, 8, 15, 22 schedule for 1st cycle only in cast nephropathy; or VDT-PACE type regimen
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A phase 3 trial of BCMA-specific CAR T cells in relapsed and refractory myeloma showed an advantage over standard therapy (progression-free survival, 13.3 vs. 4.4 months); 39% of patients in the ide-cel group had a complete response. https://t.co/i0BaknXtNB
#CART23
#tnbc#MpBC#Bcsm Just opened phase 1/2 study for orphan and lethal metastatic Metaplastic breast cancer. Supported by NCI U01, pts receive drugs that block the two oncogenic drivers of this rare disease - PI3K & iNOS (LNMMA). Preclinical data stunning. All referrals please