Karan Mahe, He/Him

Neurobiology Ph.D. student @Caltech, interested in gene therapy, 🏳️‍🌈, I support Diversity, Equity, and Inclusion

[Karan Mahe, He/Him @karan_mahe]

@ABC This is NOT news

[Karan Mahe, He/Him @karan_mahe]

https://t.co/G8VAMcfcuj

[Karan Mahe, He/Him @karan_mahe]

Just a name can change your chances in academia. Audit study shows that emails from PhD applicants with non-White names received fewer and more negative replies than those with White names, highlighting systemic racial bias. Gender had minimal impact. #AcademicBias #Equity

[ElowitzLab @ElowitzLab]

Astonishing AI system can write original papers from data sets, and does so in a way that is fully and easily human-auditable.

[Karan Mahe, He/Him @karan_mahe]

@trose_neuro Anyone knows how dexamethasone affects GCaMP imaging in mice?

[ElowitzLab @ElowitzLab]

Just posted a preprint on our new spatial genomic recording system, baseMEMOIR.
https://t.co/ef5i8FnIOw
Motivation: Cells divide, differentiate, and migrate to form exquisitely organized tissues. Reconstructing the dynamic histories of individual cells, including their lineage relationships and ancestral states, is essential for understanding how intrinsic and extrinsic signals generate tissues during development and in regenerative medicine.
Engineered genomic recording systems can reconstruct cell lineage histories from endpoint measurements. However, existing methods either require sequencing (disrupting spatial organization) or have been limited in memory size and scalability.
To address this need, @ChadlyDuncan, Kirsten Frieda, and others in the lab created a high memory capacity image-readable recording system termed baseMEMOIR.

[Ewa Zarnowska 🦄 🧠 🔬 @ewadorotaz]

🧠 I'm intrigued by GABA and inhibitory transmission, but to facilitate communication between neurons, an excitatory neurotransmitter - Glutamate - is essential. The recent surge in all-optical investigations of brain function has led to the development of fluorescent probes for neurotransmitters, marking an exciting and dynamic field in neuroscience.

The first generation of the glutamate fluorescent reporter (iGluSnFR) was developed in @LoogerL's lab at @HHMIJanelia. Now, a new, third-generation biosensor iGluSnFR3 from @PodgorskiLab's lab at @AllenInstitute provides fast tracking of glutamate release in synapses with unprecedented temporal and spatial resolution.

#neuroscience #microscopy #fluorescence #FluorescenceFriday

https://t.co/HjrLJfsKuB

[Mikhail Shapiro (same on bsky) @mikhailshapiro]

Can we image intracellular calcium with ultrasound?

Yes, w/ultrasonic reporters of calcium - URoCs!

Congrats to @ZhiyangJin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles.

https://t.co/cXqHM3awH4

[Karan Mahe, He/Him @karan_mahe]

@jdpereira @manasiagrawal1 Thank you so much!

[KahanLab @anat_kahan]

Very excited to share our research (Gradinaru lab @Caltech) about light perception looking at retinal connection to the circadian rhythm pacemaker, using bulk and single-cell imaging of SCN-VIP neurons. @PegahKF, Alexander Wang, Sayan Dutta, @karan_mahe
https://t.co/tCHMF9eNIJ

[Karan Mahe, He/Him @karan_mahe]

@koen_vervaeke @hb_cell This is a Thy1-GCaMP6s strain!

[Karan Mahe, He/Him @karan_mahe]

Check out these incredible projections of firing GCaMP neurons in the mouse motor cortex using 2p imaging! #Stunning #Science #GCaMP #Cortex #Caltech

[Erik A. Rodriguez @erin_rod_phd]

😮Have you seen a nucleus jump into another cell & become multinucleated?😮
I have & now you have!
🚦The sensor is the far-red (smURFP) & near-infrared (IFP2.0) fluorescent ubiquitination-based cell cycle indicator (FUCCI).🚦
#FluorescenceFriday #SciArt #SciComm

[President Biden Archived @POTUS46Archive]

Today, the People's House – your house – sends a clear message to the country and to the world.

America is a nation of pride.

[Karan Mahe, He/Him @karan_mahe]

@ljpilaz @zenbrainest @NikonUSA @C_Kittock 🤯🤯

[Karan Mahe, He/Him @karan_mahe]

After months of troubleshooting and constant head-fixed imaging, I’m so happy to see my very first success in 2photon imaging of GCaMP6s neurons in the mouse motor cortex !! Hopefully, the first of many…. 🧠

[Mengyu Liu 刘孟宇 @MengyuLiu96]

My first work is out on Neuron today!
[To love or to hate, that is the question.] If you are wondering why mothers change their social behaviors, check out here! 👇
https://t.co/yNUtIf9nBo
The best way to start a new year!

[Karan Mahe, He/Him @karan_mahe]

I found this very inspirational! https://t.co/yjKLg1bzxc