COMPASS: a new pan-cancer foundation model that predicts who will respond to immunotherapy from routine tumor RNA-seq.
Trained on 10,184 tumors across 33 cancers, it outperforms 22 methods across 16 clinical cohorts (7 cancers, 6 ICIs):
⭐️+8.5% accuracy
⭐️+15.7% AUPRC on average
It generalizes to unseen cancer types and treatments, and predicted responders show massive survival benefit (HR = 4.7).
The real magic? It uses 44 biologically grounded immune concepts + personalized response maps to reveal why patients respond or resist including TGFβ signaling, endothelial exclusion, CD4⁺ T cell dysfunction, and B cell deficiency even in “immune-inflamed” tumors.
https://t.co/TiXQPFglUH
الصورة الرسمية لبعثة منتخبنا الوطني المتوجهة إلى الولايات المتحدة الأمريكية للمشاركة في كأس العالم 2026 🇲🇦🌍
Official team photo of our National Team delegation heading to the United States for the FIFA World Cup 2026 🤩🦁
#DimaMaghrib
"I can relate to what Vinícius Jr. is going through.. At times you feel lonely because it's going to be your word against his word."
Thierry Henry reflects on the incident between Vinícius Jr. and Gianluca Prestianni 🗣️
One of the most beautiful things you’ll see all year.
Valentin Vacherot is the first to step on court & congratulate Arthur Rinderknech as he joins him in the Shanghai final.
Two cousins reaching their 1st Masters 1000 final together.
Family goals. 🥹
Novak Djokovic says Jannik Sinner & Carlos Alcaraz are too good:
“I lost 3 out of 4 slams in semis against these guys. They’re just too good.”
“Best of 5 makes it very very difficult for me to play them. Particularly at the end stages of Grand Slams.”
(via U.S. Open Press)
Most viewed this week from @JAMAOnc:
While phase 3 oncology trials frequently report success based on alternative endpoints, actual enhancements in overall survival and quality of life are uncommon.
https://t.co/4ZmqpzR6cQ
Presented at #ASCO25:
A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone. Full CHALLENGE phase 3 trial results: https://t.co/j3kWJDjuVz
@ASCO
Jude Bellingham: “I asked José Mourinho for a picture with my mum, she’s fancied him for years!".
📸 Jude Bellingham takes the picture…
Jose Mourinho: "Now you come to Fenerbahçe!" 💛💙