Good morning. Please take your time to read this. It is important. I worry for my children and yours too. I waited for a while to tell you the story about this liver.
I wanted to make sure it ended well. This is was the liver of a teenager we took out a month back. He was flown in from another State because of an unidentifiable jaundice + hepatitis that was making him sick. Hardly a few days in, he went into a coma because of liver failure and we put him on a ventilator. To help him survive, a parent donated part of the liver. This was the quickest emergency liver transplantation we ever did. Everything happened in less than 24 hours.
On the outside the liver looks pretty normal, just a bit swollen from the hepatitis (liver inflammation). But when we looked at it under the microscope, there was nothing left. Almost all the liver cells were wiped out (a finding known as massive hepatocellular necrosis) with deep inflammation.
The cause remained unknown. We call it indeterminate hepatitis - meaning, something we did not know, caused it.
You may remember post Covid-19 era. There were multiple cases of unknown hepatitis among children which either led to them dying or receiving a transplant. At the time, scientists thought it was due to another virus - Adenovirus, that had changed the way it attacked us due to Covid-19 era restrictions and immune changes. But that theory fell apart because not every kid with indeterminate hepatitis had adenovirus positive.
In the 1980s, some doctors in few hospitals across the world described a handful of single-center cases that first documented liver cell loss and inflammatory infiltrates in unexplained pediatric liver failure. And they kept seeing such cases, here and there, and forgot about it. Some died. Some lived after a liver transplant.
In 1999, with the establishment of the Pediatric Acute Liver Failure (PALF) study group allowed for systematic tracking and larger-scale retrospective and prospective analysis of immune functionand dysfunction in such kids with unknown hepatitis.
In 2022, medical scientists were armed with better technology and more impressive analysis methods. And global attention surged, in the post-Covid-19 era on outbreaks of severe acute hepatitis of unknown origin in children.
https://t.co/ktKVaLQjcQ
They figured it out. Just like we did.
A special stain and a technical advancement known as immunohistochemistry, a lab test that used antibodies to find specific proteins in a tissue sample was deployed. A special type of immune cell, supposed to defend us, was going crazy. Cytotoxic T cells act as the body's security guards to find and destroy cells infected by viruses or those that turned cancerous. There was no cancer in our teenager. And teenagers and children with this disease before him. The most likely culprit was a previous viral infection.
https://t.co/JicKah98a4
Covid-19 probably increased this. The little fcker wrecks havoc on the immune system like no other. It makes the body go wild and attack itself. It has done this before in other other organs too. It is called molecular mimicry.
When you get infected with COVID-19, your immune system creates defenses—like antibodies—to target and destroy the virus. To do this, it memorizes the physical shapes and protein sequences of the virus. However, because some building blocks of the COVID-19 spike protein mimic the shapes of our own healthy human proteins, the immune system can experience "cross-reactivity". Your newly trained antibodies end up attacking both the invading virus and your own healthy organs because they cannot tell the difference.
https://t.co/8baDr9nvJa
Large numbers of children with indeterminate hepatitis have cytotoxic T-cell mediated hepatitis. And it can only be diagnosed through a liver biopsy before the kid got really sick or after a liver transplant when the kid was going to die.
The liver that you see below, is far from normal. Deep within these tissues was a horde of cytotoxic T-cells that were picking of large areas of liver cells, pushing the child towards death.
As a doctor, I was only able to give them a diagnosis, after the liver came out and because they were convinced about this hidden killer of children, we did it in the nick of time. The teenager survived and we found what nearly killed the patient.
Any viral infection can lead to this. Not immediately, but even later on in life. It happens mostly in children, teenagers and young adults. Vaccines prevent/ reduce severity of various viral infections. Please make sure you and your children are vaccinated for age.
I hope Governments everywhere promote annual vaccinations for Covid-19 too along with the flu-shot. Because there is a strong possibility that this is the one virus that can cause this type of damage on the liver, many months after the initial infection and we may never know - becuase Covid-19 can come and go silently.
இந்த வீடியோ பாக்குறப்ப மணியன மட்டும் பாருங்க என்ன பண்றதுனு தெரியாம பம்புறான்🤣🤣🤣
யாரோ சின்ன பையன் கண்ண உருட்டி ஏமாத்தி narrrative பண்ணலாம்னு வந்து வசமா மாட்டிக்கிட்டான்
Imagine if @Udhaystalin skipped a State visit by the Malaysian Prime Minister to fly to London under the guise of an “official investment trip,” only to end up at Silverstone waving the flag at a car race. The internet would have exploded.
The media analysts and YouTube influencers would be calling it a waste of public funds, a diplomatic insult, and total administrative incompetence.
Yet, when @TVKVijayHQ does it, his fanbase spins it as “building Brand Tamil Nadu” and “showing love to a star friend.”
While Udhayanidhi faces non-stop scrutiny for every official move, Vijay gets a free pass to treat state business like a high-profile movie promotion. A blind cult following doesn't just forgive political accountability, it is actually rewriting governance into spectator sport.
No better sign of the times than media houses from Chennai to Delhi climbing all over each other to hype this "race" in rural England, while Tamil Nadu suffers rampant crime and ubiquitous power cuts...
The people get the government, and the parasitic media, they deserve...
#வினா : மின்கட்டணம் ஏன் அதிகமா வசூல் பண்றீங்க
#விடை : அமைச்சர் : உதய் 3 மணிநேரம் பாத்ரூம்ல இருந்தார்.
#வினா : சட்டம் ஒழுங்கு காக்க என்ன திட்டம் இருக்கு?
#விடை : Anna, MGR, NTR, Vijay.
இதுல விஜயை சமாளிக்க முடியாம திமுக வெளிநடப்பாம் 😂🤣
எல்லா கார்டும் ஜோக்கர்ன்னா எப்படி!? 🤮
Total circus going on. AIADMK MLA now asks Hosur Airport to be dropped like Parandur as it affects farmers & agri land. TN Minister Sengottaiyan says for any project agri land has to be acquired. Just 2 days ago exact opposite was said. Enna dhan nadakudhu....🤧😩
பரந்தூர் விவசாயிகளுக்கு ஒரு நியாயம் ? ஓசூர் விவசாயிகளுக்கு ஒரு நியாயமா ?
ஒசூர் அதிமுக எம் எல் ஏ பாலகிருஷ்ணரெட்டி - விவசாயிகளின் எதிர்ப்பால் பரந்தூர் விமான நிலையத்திட்டத்தை கைவிட்டதைப் போல ஒசூரில் விவசாயத்திற்கு பாதிப்பை ஏற்படுத்தும் புதிய விமான நிலையத்திட்டத்தை கைவிட வேண்டும்
அமைச்சர் செங்கோட்டையன் - எந்தவொரு திட்டமாக இருந்தாலும் விவசாய நிலங்களைத் தான் எடுத்தாக வேண்டும். வேறு வழி கிடையாது
#WALIAIT Volume IX: The Intentional Amnesia of Digital Brand Management!
We are witnessing a highly coordinated exhibition of MANUFACTURED IGNORANCE where routine administrative continuity is aggressively rebranded as an instantaneous political miracle. The online narrative surrounding the flagging off of 130 new AC electric buses perfectly illustrates how modern PR setups operate. They intentionally delete structural timelines to MANUFACTURE UNEARNED POLITICAL CREDIT.
The absolute logical fallacy of these online posts is glaring. The primary operators of these accounts are completely aware of how governance functions. They know that a brand-new administration, barely 100 days into its tenure, cannot miraculously float a global tender, finalise complex international funding structures, construct necessary depot infrastructure, and manufacture hundreds of high-tech electric buses overnight. These capital-intensive infrastructure projects are the results of extensive bureaucratic pipelines and gestation periods initiated and budgeted long before the current leadership took office.
Yet, the DIGITAL ECHO CHAMBER behaves as if the entire public transport system lay entirely dormant until a single ribbon-cutting photo-op occurred. When clear evidence is presented showing that brand-new AC buses have already been operating on Chennai & other city roads for over a year, the defensive pivot is immediate: "I did not say they were not running, I just said I did not know when they were bought".
This is a deliberate, cynical execution of an Epistemic Coup. The goal is to aggressively scrub institutional history so that the public is systematically conditioned to attribute every routine output of the state machinery entirely to a centralised, MODERN PERSONALITY CULT.
We Are Living In An Interesting Time!!!
#WALIAIT #TNPolitics #TVK #CMVijay #TamilNadu #EpistemicCoup