Katherine Law

Doctor - Consultant / Attending Geriatrician on a career break 🇭🇰🇬🇧🇺🇸 Thinking about ageing / future of healthcare. What’s next? 🌞🌊

[Katherine Law @katalog]

how it started how it’s going

[Eric Topol @EricTopol]

The cancer-Alzheimer's paradox, an inverse correlation, with an unexplained mechanism
"The risk of Alzheimer’s disease in patients with cancer is significantly reduced, and the risk of cancer in patients with Alzheimer’s disease is halved."
https://t.co/JOI0agYsWq

[Eric Topol @EricTopol]

For medical information, general AI frontier models (Google, OpenAI, Anthropic) outperformed specialized @EvidenceOpen and @UpToDate as assessed by 12 US clinicians, randomized and blinded to which model and extensive testing/benchmarks. This was not anticipated. @NatureMedicine
https://t.co/KCH1ADfQWz

[Julio La Torre, MD @jclatorre]

I recently took @tszzl and @RichardHanania (true story lolz-and both advisors to my new venture in full disclosure) to one of the countries largest academic medical centers.

@tszzl has since wrote a viral X thread thats worth reading again https://t.co/2LCP2VOVdg

It speaks for itself. I'll just add if he's surprised by the missing data .....he'd be further surprised by the data we do capture: fragmented, delayed, and built for billing, not clinical insight. It tells us very little about human disease and how to truly treat it.

Epic Systems is at the center of this monumental failure.

Simply put: AI cannot reach its full potential in medicine while Epic Systems controls the underlying data architecture. The ideas are fundamentally oppositional at their core.

I explain why Epic's culture, regulatory inertia, and the staggering $1B sunk costs of its clients do not guarantee its dominance but if anything bring a slow march into irrelevance.

[John Collison @collision]

Dave Ricks has been at @EliLillyandCo for 20% of its 150-year history. He came to the pub, poured his own Guinness, and gave us a 2-hour state of the pharma union: drug prices, clinical trials, patent clocks, the rise of generics, Chinese peptides, compounding pharmacies, the US healthcare system, and how the broad success of GLP-1s have transformed Lilly's business. If you've never heard Dave speak before, you're in for a treat.

Timestamps:
00:00 Intro
05:08 Making R&D decisions
10:11 Clinical trials
24:59 Drug pricing
32:43 Stimulating more R&D
45:16 Pros and cons of US healthcare
58:20 New pharma business models
01:05:53 Stripe + enterprises
01:07:00 China
01:16:31 Generics
01:22:37 GLP-1s
1:37:43 r/Peptides
01:41:25 LillyDirect
01:46:35 Why do investors love LLY?

[Katherine Law @katalog]

@DrEilidhMaria Or Another Place

[Katherine Law @katalog]

@DrEilidhMaria Low wood bay!!

[Arjun (Raj) Manrai @arjunmanrai]

A few months ago, we were both excited and nervous to stage a public face-off at @Harvard between “Dr. CaBot,” our AI system that simulates an @NEJM expert discussant, and a real @NEJM discussant & expert diagnostician.

Today, @DhruvKhullar tells the story in The New Yorker.

[Katherine Law @katalog]

@RuxandraTeslo @HFEA @CRGHFertility @TheEvewell In the US they often quote a paper from 2017 that you need 15-20 eggs for one live birth: https://t.co/AcsYcUL9e7.

[Eric Topol @EricTopol]

Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)

[Katherine Law @katalog]

Moved to SF for over a month and just realise I haven’t seen a single smoker / cigarettes??

[Katherine Law @katalog]

@PPLXsupply @perplexity_ai @AskPerplexity @PPLXsports @PPLXfinance @perplexity_jp @banburismus_ extra GPU for you power up!

[Katherine Law @katalog]

What an incredible week!

[Samuel Hume @DrSamuelBHume]

Top 5 advances in medicine this week (🧵)

1. Gene therapy provided sight to children born blind

The 4 children had a rare form of blindness, caused by mutations in the retina gene, AIPL1

A functional copy of this gene was introduced, in one eye per patient, using the other eye as a control

All of the children started to see (though imperfectly): they started to draw and write, moved around on their own, and played with others

This is not the first time gene therapy has been used to treat blindness (there is even an approved therapy for inherited RPE65 mutations)

This approach is now being rolled out more widely to children affected by AIPL1 deficiency

Study: https://t.co/rYBkqPUPeo

[Katherine Law @katalog]

Tale of resilience and survival by two amazing female alpinists of our times in the Himalayas https://t.co/GqO61Wn0sh

[Katherine Law @katalog]

I am interested in health (obv) but also in other wellness pursuits - yoga, running, outdoors, vino.

[Katherine Law @katalog]

Some of you might know that I am moving to the US and will be based in SF! Thinking about next steps and interested to meet people in medicine / health and O3 spouses wanting to hang out:)

[Katherine Law @katalog]

Food for thought re anticoagulation for the frailest

[Martin Glasser @martinglasser]

@sean9n This study suggests that, certainly for the frailest people, the benefits of anticoagulation do not outweigh the risks. Especially as the priority for those people may be increasing time out of hospital, rather increasing time alive at all costs

https://t.co/Sx4WkYmoDG

[Katherine Law @katalog]

“In medicine, we have a deep opportunity for perdurance… leaving a lasting impact beyond the time we exist.” Thank you for a thoughtful post @sean9n not only on medicine but also the meaning of practising it.

[Sean Ninan @sean9n]

What’s wrong with medicine? A geriatrician’s perspective.
https://t.co/maXja6H2nh

@lucypgeridoc @EileenBurns13 @mancunianmedic @Trisha_the_doc @danfurmedge @jupiterhouse1

[Katherine Law @katalog]

@KarenKee10 @KarlTheFog Hello! I came across your profile - I am a consultant geriatrician in London moving over to San Francisco soon, would be nice to connect! Please follow me and I can DM you? Thanks - Kat

[Katherine Law @katalog]

@naeimhos Try to see if current dr / rota coordinator can add you to WhatsApp group so you can ask if anyone leaving their accommodation soon?

[Katherine Law @katalog]

@jfnephlolz Out of interest, do you have access to study budget as consultant?