Excited to share a study led by postdoc Pan Yang and grad student @VirologyHarvard Wanyu Li that solves part of a missing puzzle on how eastern equine encephalitis virus, one of the deadliest viruses endemic to North America, infects cells. 🤩 @biorxivpreprint@HarvardMicro
Special shout to the @HC2EM staff and all others who contributed including co-authors @TheColinMann@katherine_nabel @SarahA_Clark. Read the paper here!
https://t.co/Q0W6qIljin
TODAY at 2:00 PM ET, Katherine Nabel (Abraham lab) defends her dissertation "Molecular mechanisms for broad neutralization of emerging RNA viruses".
To access Zoom: https://t.co/PJLqi8CESa
@dylanvneel@winstonxyan Re-exposure with the same variant may not help with exposure to a strain as divergent as Omicron is. I think we're going to need an Omicron boost
@dylanvneel@winstonxyan Quantity of ab response is important, but so is quality. One concern that I have is that you can make a lot of ab, but if it's not directed at the right epitopes, it's not going to help. Epitope breadth is very important. Boosting with same strain may give quantity not quality
The #SARSCoV2 spike protein receptor binding domain, altered w/ combined mutations, is more resistant to neutralization by antibodies & by serum from vaccine recipients. Results point to continued emergence of escape variants as SARS-CoV-2 adapts to humans https://t.co/xCfqS2E5r5
https://t.co/f1RFeQjLu8
The landscape of mutations that could lead to antibody escape in #SARSCoV2 remains under-sampled among circulating variants.
Lucky to have been a part of this incredible group of researchers.
@abrahamlabhms
The #SARSCoV2 spike protein receptor binding domain, altered w/ combined mutations, is more resistant to neutralization by antibodies & by serum from vaccine recipients. Results point to continued emergence of escape variants as SARS-CoV-2 adapts to humans https://t.co/xCfqS2E5r5
Thank you, Jake Miller, for the wonderful piece on our lab's latest paper. The next step, confirming hypotheses based on our work but using #OmicronVariant will keep us all busy, unfortunately.
https://t.co/3MrazlTmzl
We worked with an incredible team to study how structural plasticity in the SARS-CoV-2 RBD allows the virus to escape human antibody responses. Thank you @mgh_id@bwh_id @MassCPR @HarvardMicro@VirologyHarvard for working with us and for your support of this project!
Excited to share our manuscript just published @ScienceMagazine describing mechanisms for continued antibody evasion of the SARS-CoV-2 RBD. Hopefully, the findings help us better prepare for #Omicron.
https://t.co/DO3RZEo8Rz
BREAKING NEWS:
The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”