Kesshni Bhasiin

probably thinking about glial cells (or chocolate)🧠👩🏽‍🔬

[Kesshni Bhasiin @kesshni]

@DuSiling Big big congratulations, Siling! Really excited to see🥳

[Kesshni Bhasiin @kesshni]

Highly recommend applying to Li-Feng's new lab to work with an incredible scientist and mentor!!😁

[Li-Feng Jiang-Xie @neurobenjamin]

My lab at Penn is hiring at all levels! We have posted a Research Specialist position on Careers@Penn (link below), and we are also actively looking for postdocs and graduate students. If you're interested in the science of sleep and neurodegeneration, please consider joining us!
https://t.co/ZEtsm96UVf

[Li-Feng Jiang-Xie @neurobenjamin]

Excited to share our work published today. We identified that neurons are the master organizers for brain fluid perfusion and waste clearance. Inspired by Hebbian rule and Carla Shatz’s phrase, we summarize it as 'neurons fire together shower together'.
https://t.co/Yc7W2RKGhk

[Jonathan Kipnis 🟦 @jonykipnis]

In 1992 @SciAM article, Carla Shatz summarized Hebb’s theory as “Neurons that fire together wire together”. Today, inspired by Carla's phrase, we bring you “Neurons that fire together shower together”. Why do we sleep? Why to we emit waves? @neurobenjamin attempted to answer these questions https://t.co/pTg4n9Jfpw

[Leon Smyth @lcdsmyth]

I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. https://t.co/tP4TIc986A

[Eric Topol @EricTopol]

“A new type of vaccine… has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes—all without shutting down the rest of the immune system.”
Leveraging the liver!
see Ground Truths link in my profile
X-suppressed

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Chan Zuckerberg Biohub Network @czbiohub]

New in @ScienceMagazine, the Aging Fly Cell Atlas maps 868K single-nucleus transcriptomes at multiple time points across the #Drosophila lifespan.

https://t.co/6E18N8XR5K

All data freely available at https://t.co/6CtSgOGbO3

[Stephanie Deppe, PhD @SpaceSciSteph]

When an "imaging artifact" turns out to be one of the wildest things we've ever observed in the universe.

A supermassive black hole.
Ejected from its galaxy.
Compressed gas in its wake.
AND FORMED A 200,000 LIGHT-YEAR LONG STRING OF STARS.

WHAT.

[Kipnis Lab @kipnislab]

We are grateful to be working with these brilliant and capable women, who inspire, uplift and support us, everyday! It is a joy and privilege to be doing amazing science with you. Happy International Women’s Day! 👏👑

[Dr Sarah D Ackerman @SD_Ackerman]

Happy International Women’s Day to the brilliant and talented women of the @BIG_CenterWashU ! It's such a privilege to work alongside you all and tackle the most interesting questions in neuroscience! 🧠🦠🔬🐀🪰🐟

p.s. please tag yourself if I couldn't find you on Twitter 😆

[Kesshni Bhasiin @kesshni]

@papersofnote Thank you so much for highlighting our work! I’m excited to see that you find it useful for your work and look forward to following your future discoveries☺️🥳

[Kesshni Bhasiin @kesshni]

Excited to have part of my undergraduate work out in the world! We’ve optimised analysis and methods for the dye-exclusion assay in adult Drosophila.

A big thank you to everyone, especially the best labmate (Olivia) and PI (@KenColodner) a young scientist could ever want!☺️🥳

[Ken Colodner @KenColodner]

Very happy to share my lab's recent work optimizing the dye-exclusion assay in adult Drosophila. If you are interested in assessing brain-barrier integrity in the adult fly, check it out. This was the work of two outstanding recent Mount Holyoke alums @kesshni and Olivia Heintz.

[Nature Biomedical Engineering @natBME]

Inflamed heart tissue after myocardial infarction can be repaired via an intravascularly infusible degradable matrix that binds to leaky vasculature.

https://t.co/aaVq1D8LmD [N&V]
https://t.co/khgUD3ttk1 [Paper]

[Pramesh CS @cspramesh]

All in one week...

[Maly Cosco @malycat03]

Impactful words by @CarolynBertozzi today on how diversity in her trainees enabled creativity, not playing by the rules, and ultimately the work that built the field of bioorthogonal chemistry. Diverse science leads to better science!

[Stanford University @Stanford]

"I understand the gravity of being a woman and now a #Nobel laureate in the sciences. There aren't that many of us—yet."

Prof. @CarolynBertozzi on chemistry, mentorship and representation ⬇️

[Jill Ward @WardLab_Emory]

Great read. Rita Montalcini-Levi’s work during WWII helped her survive. I knew about her work on NGF, but not her initial discoveries. Remarkable woman.
#neuroscience

https://t.co/IX1dDHFqib

[Amy Stuart @AmyfStuart]

While grappling with cancer, Dr. Chaudhri has used her platform to raise funds for an awards program for young scientists from diverse and underrepresented backgrounds. Tonight, that fund sits $1300 short of its 200k goal. Let’s get her over the mark.

https://t.co/I3bKlPpEqQ