Li-Feng Jiang-Xie

Neuroscientist | Assistant Professor at Penn | Duke & NTU alum | Exploring brains—biological & artificial | We're hiring!

[Sang Soo Lee @SangLee723]

I'm excited to share that I will be joining the @UBBiology as a TT Assistant Professor, starting in January 2027!

My lab will study the neural circuit mechanisms underlying internal states, with a particular focus on sleep, circuit plasticity, and behavioral regulation.

[Hanfei Deng @hanfei_deng]

Excited to share our latest work with @xiaoxiong2n in @NatureNeuro! 🧠⚡🐭

We uncover how vagus nerve stimulation alleviates pain and modulates pain-related negative affect via a cNTS–PAG–VTA–NAc dopamine circuit.
https://t.co/Kn3INjSG9X

[Lex Fridman @lexfridman]

I got to spend all day today with Jensen in Taiwan: talking with thousands of engineers and eating street food at a night market. Jensen is received as a rockstar in Taiwan, like it's Beatles in the 60's. It's mind-blowing and fun to watch. But most importantly, through all the interactions and all my conversations with him, he remained the same humble, kind, thoughtful, funny guy he always was, even as a kid who went to these same night markets many years ago.

Btw, we tried a crazy amount of different street food. It's legit some of the most delicious food I've ever had. I can't wait to share video of it, including a ton of our conversations and hangout. When I can pause for a moment from all the travel to edit the video, I'll post it.

Can't wait to continue talking to Jensen and engineers at Computex this week, and exploring more of Taiwan, and of course roaming the night markets for some more delicious street food.

Days like these, even more than usual, I feel like the luckiest kid in the world.

Love you all! ❤️

[Nalini Rao @NaliniRRao]

Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9

🔗 https://t.co/1s7AcXZcv4

[Li-Feng Jiang-Xie @neurobenjamin]

@StevenBremMD Thank you, Steven! Kesshni will be a great physician-scientist!

[Prof. Kevin J. Tracey, MD @KevinJTraceyMD]

Congratulations to everyone at Setpoint Medical, present and past, who worked for 18 years to bring a brand new idea for the first time into a clinical reality. This begins a new era for millions of patients needing new options.

https://t.co/kKfveTu54t

[Shun Li @shunnnli]

Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦?

Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃?

Excited to share my thesis work in @blsabatini lab!

🧵 ⬇️ (1/13)

[Raffaele Sarnataro @RafSarnataro]

1/ 🚨 Our new paper is online in @Nature !
As its first author, I’m enthusiastic to finally share it with you all!🎉
🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤
👉 https://t.co/eBUKpM3zJa
@OxfordDPAG 🧵👇

[Sang Soo Lee @SangLee723]

It’s been a rewarding journey studying sleep as a postdoc, and I’m now exploring faculty positions in neuroscience.
My latest work uncovers a neural circuit mechanism for homeostatic sleep.
Open to opportunities and always happy to chat!
🔗 https://t.co/vnWq8vfDhJ

[Jeffrey Iliff @Jeffreyiliff]

Our review, led by @SamanthaKeilPhD , providing a critical and up-to-date assessment of the role that glymphatic dysfunction plays in the development of clinical Alzheimer's disease, was published in @ScienceMagazine today: https://t.co/O0YHceueZT

[Li-Feng Jiang-Xie @neurobenjamin]

@ysA3mWQRDEY Thank you! We do welcome computational neuroscientists.

[Li-Feng Jiang-Xie @neurobenjamin]

My lab at Penn is actively seeking motivated and creative Postdoctoral researchers to join our team. Candidates with strong experience in electrophysiology, imaging, proteomics, or molecular biology are especially encouraged to apply.
https://t.co/daYUjyCXST

[Prof. Kevin J. Tracey, MD @KevinJTraceyMD]

Thank you Jonathan, Mina and Joe for having me on @Morning_Joe to discuss #TheGreatNerve!

[Prof. Kevin J. Tracey, MD @KevinJTraceyMD]

Great progress here in this elegant work revealing new #vagus mechanisms as the basis for future therapeutics. @changsbrain

[Jeffrey Iliff @Jeffreyiliff]

Our new paper with Applied Cognition in @natBME . Using a wearable device that captures different determinants of glymphatic activity to define sleep-related features of glymphatic function in the human brain. https://t.co/VIxAO5VG6t

[Li-Feng Jiang-Xie @neurobenjamin]

@jonykipnis Thank you Jony! 👍

[allen institute @AllenInstitute]

How does the brain work?

Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

[Breakthrough @brkthroughprize]

David Liu wins the Breakthrough Prize in Life Sciences for developing gene-editing technologies, including a "molecular word processor" that can find and replace whole sequences of DNA. His tools are already impacting diseases including cancer. https://t.co/OSDzo6jeS7
@broadinstitute @HHMINEWS @Harvard

[Li-Feng Jiang-Xie @neurobenjamin]

@dingliuabc @DulacLab Huge Congrats, Ding!! Can't wait to read it!