Richard Morris

Biochemist, podcaster, research student, software developer

[Richard Morris @khiron]

@MacroFour 10 years on April 20th. Which means statistically none of my fat cells will remember being type 2 diabetic fat cells, as adipocyte residence time is evidently 10 years.

[Richard Morris @khiron]

@nicknorwitz @washingtonpost It is also true that humans can become shorter by maintaining a permanent crouching posture.

I suspect if you locked subjects in a ward with a lowered ceiling, they would be able to sustain that almost indefinitely.

[Richard Morris @khiron]

@nicknorwitz Delay answering the question, while sampling each to make up my mind, until there is no more cheese ... then ask "What was the question again?"

[Richard Morris @khiron]

@richcollins @lowcarbGP @AbilitiesB @realDaveFeldman Most lipid draws are 10 hours fasted

ie: empty buffers. But a lot of empty buffers. Suggesting upregulated capacity to adequately fuel a fat adapted lean subject between meals when adipose is not enough

[Richard Morris @khiron]

@lowcarbGP @AbilitiesB @realDaveFeldman Adipose has a rate limit

Leanness is not evolutionarily conserved for a reason - so your lineage could survive a day of bad hunting

An adaptation to insufficient buffer is more buffers - and circulation is a buffer of FAs via APO-B particles

[Richard Morris @khiron]

@FrogHarmless @MacroFour @KetoCarnivore @DrFeinman Baseline RQ of non MS cohort

Induce transitory insulin resistant with several hours of infusion of 20% TAG emulsion with heparin (per Shulman https://t.co/yXwi24c8Gw)

Re-measure RQ

If they are burning more FAs than at baseline the alternative hypothesis can be rejected

[Richard Morris @khiron]

@HugoMacdermott @MeganLOMara Congrats Dr :)

[Richard Morris @khiron]

@BelindaFettke @Leafiehealth @FructoseNo @zoeharcombe 4 legs good ... 2 legs bad.

[Richard Morris @khiron]

@MarikaSboros In person he emitted creepy vibes. I wrote those off as maybe just cultural differences I should be more tolerant of ... should've trusted my 1st instinct

What a creep

[Richard Morris @khiron]

@KenDBerryMD GLP-1's physiological role is to prime the gut for digestion by releasing a little insulin till the pancreas can get an accurate read on expected glucose, and switching off hunger till the gut can get a read on expected calories.

Not convinced being in that state 24/7 is ideal

[Richard Morris @khiron]

@nicknorwitz GLP-1's physiological role is to prime the gut for digestion by releasing a little insulin till the pancreas can get an accurate read on expected glucose, and switching off hunger till the gut can get a read on expected calories.

Not convinced being in that state 24/7 is ideal

[Richard Morris @khiron]

@Drlipid Inhibiting transport of fatty acids "the last mile" across the mitochondrial membrane might do it. They are lipids, right?

[Richard Morris @khiron]

@robertlufkinmd @Sam_Apple1 Is there an online source for this clipping?

[Richard Morris @khiron]

@HeatherMAitken @ourANU Ok Doc :)

[Richard Morris @khiron]

@live_intheflesh @KetoCarnivore @FrogHarmless @DrFeinman Fair enough.

Mind you I'm not sure that nutritional scientists contributed much to the definition of how much energy raises 1g of water from 14.5C to 15.5C by determining that 1 Calorie is also precisely equal to 1000 calories

[Richard Morris @khiron]

@Alundra @KingManninen @raphaels7 @DietDoctor Insulin signalling increases transcription of and activation of the rate limiting enzyme (Acetyl-CoA)

Lowering insulin potentiates fatty acid mitochondrial transport and oxidation

Between meals in mild cases, chronically in severe cases

[Richard Morris @khiron]

@FrogHarmless @KetoCarnivore @DrFeinman Potential value ... if you can get the fuel into the furnace

If not and you have a disposal pathway (glucose->urine) it's just inefficient conversion. If you don't have a disposal pathway (eg: fatty acids) then it's an episode of "Hoarders"

[Richard Morris @khiron]

@cancerclasses @FrogHarmless @KetoCarnivore @DrFeinman Water is a product of metabolism not a factor

[Richard Morris @khiron]

@live_intheflesh @KetoCarnivore @FrogHarmless @DrFeinman Technically calories are work, not potential work. Metabolic fuel (glucose,fatty acids) can be turned into metabolic work if they can be metabolized into ATP

Hyperinsulinaemia inhibits mitochondroal membrane transport of fatty acids, and plasma membrane transport of glucose

[Richard Morris @khiron]

@raphaels7 IOW if you want to weigh less go for a run - your body will soon work out this animal needs to be lighter to hunt and set the buffer it defends lower.

Nothing to do with calories out, more like information in

[Richard Morris @khiron]

@raphaels7 Define "works" - keto reversed my type 2 diabetes, and hasn't stopped keeping it reversed 8 years later