Basics of Glomerulonephritis (GN). GBM is key.
All patterns can be explained by glomerular basement membrane (GBM) & type of injury.
Let’s do one at a time
CRESCENTIC GN
1. Results from breach/break of GBM (red arrow)
2. Injury is sudden & severe
Eg-ANCA & anti-GBM GN
1/6. Here is my approach to work up of the antigens in membranous nephropathy (MN). It’s not perfect. @NephRodby@GlassockJ
Start with the common (~60 %) group: This includes:
PLA2R, followed by
NELL1.
Fibrous crescents can be differentiated from ischemic obsolescent glomeruli based on the pattern of global sclerosis. #NephTwitter https://t.co/Z4FlfK1RyN
The honourable secretary of the Indian Society of Nephrology assigned me to debate the notion “Rituximab is the 1st line therapy for MN” for ISNCON2022. I thank him for the same. Though would have liked to defend the “CON”! My thoughts on the allotted topic. (Tweet 1)